DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and nav2b

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:XP_021326321.1 Gene:nav2b / 557290 ZFINID:ZDB-GENE-061207-13 Length:2278 Species:Danio rerio


Alignment Length:2621 Identity:731/2621 - (27%)
Similarity:1113/2621 - (42%) Gaps:764/2621 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   480 PVPSRHVQYKIRKPRPLSTHSDADSGFLSPCSPEEMRANPAILV---LQQCDSVQGYMEIYTDWA 541
            |:|:|.|.::....:|:.|.       |.|......|:..:..:   .|......|..:||||||
Zfish    24 PIPARAVTHQNGPLKPMQTS-------LIPLKSPICRSQGSATLQRKYQTAKETSGDPQIYTDWA 81

  Fly   542 NYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKPKNQQQMFDNVNSCLHVLRSQ 606
            |:||.::..||.:.||..|..||:||||:|:.|.:.|:.|:...|:::.:|.:|:::||..|.::
Zfish    82 NHYLAKSGHKRLIKDLQQDVADGVLLAEIIQVVANEKIADINGFPESRSEMIENIDACLGFLAAK 146

  Fly   607 SVGGLENITTNDICAGRLKAVLALFFALSRFKQQAKQTKSIGV-------GCGGGVGGSSSTLTG 664
            .| .::.:...:|..|.|||:|.|||.||||:||..:..|..|       ||             
Zfish   147 GV-NIKGLCAEEIRNGNLKAILGLFFILSRFRQQTLKQASSNVQSLQHSHGC------------- 197

  Fly   665 SGSVLGIGIGGLRTP---------GSSLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMVNRQI 720
            |...|.:....:.:|         .||....|...:.|.....:.:.|:.:..|....:...|..
Zfish   198 SSPALSLHSSPVSSPCPSPIQQHYTSSTPAQKTHTDLQSSHPSKVSNQKKSTRLSVAQKNNTRLQ 262

  Fly   721 APAYAKVNGGTAIPLPATVMVQRR------C----PP--------DKVRPLPPTPNHTP---SIP 764
            :|: :|.:|.:.   |.|....||      |    ||        :|..|.|...:|.|   |||
Zfish   263 SPS-SKASGESK---PRTGSTNRRSQSFNQCDRLKPPVSAYVHEREKTTPSPIMVDHGPISSSIP 323

  Fly   765 GLGKSGSDFNTSRPNSPPTSNHTIQ--------SLKSGNNNSL----RPPSIKSGIPSPSSPQTA 817
                            ||:...|..        |.|....:|:    :||.....:|    |:..
Zfish   324 ----------------PPSCTSTASKPWRSKSLSAKHTATSSMVTVKQPPLDSLEVP----PKVI 368

  Fly   818 PQKHSMLDKLKLFNKEKQQNAVNAASVASKTQIQSKR--------------TSSSSGFSSAR-SE 867
            .|| |||:||||||.:....|.|.||......::.:.              |.:|||.:|.: :.
Zfish   369 AQK-SMLEKLKLFNNKTGSRASNVASSEDVIAVELEEGPICPIHPRNQRPVTPTSSGSTSPKLAL 432

  Fly   868 RSDSSLSLNDGHGSQLKPPSISVSSQKPQPKTKQSKLLAAQQKKEQANKATKLDKKEKSPARSLN 932
            :..:.|::    |..|.|.                  :|:.:.||:..:..||.:|||....|::
Zfish   433 KGIAQLTI----GRALAPK------------------MASAKVKEKVKEKPKLKEKEKPKQLSVS 475

  Fly   933 KEESGN--------ESRSS-TMGRTGKSSLVR-AVGGVEKNTPKTSSKSSLHSKSDSKSSLKAPQ 987
            :...|:        ||:.| ..|...|..:.: |:.|:.|  |..:.|||..:|:          
Zfish   476 EHLKGDTKTDGLVLESKKSIPKGNKAKKDIAKPAISGIPK--PSQAGKSSTLNKA---------- 528

  Fly   988 LLQSPSSGGLPKPIAAIKG----TSKLPSLG-----------GGAGHLPAAESQQNQQLLKRETS 1037
             :.||..|        ::|    ..::.||.           ..|..|..:|.:.:|.|  ..:|
Zfish   529 -VASPPCG--------VEGDRLRNGRMGSLSVHKGQKDNRNCSSASSLAFSEGKGSQDL--TASS 582

  Fly  1038 DISSNISQPPPAEPPISTHAHIHQNQTPPPPYYANSQPTSHISSHGFLSEPSTPQHSSGIYGSS- 1101
            ..:|..|.....:.|.....:.|.|.....|:...||  :.|...||::.....:..:|:...| 
Zfish   583 KTNSTASNTVSVQLPQLQQQYSHPNTATVAPFMYRSQ--TEIDKSGFVTRVEDRREWTGLCSKSI 645

  Fly  1102 ---------------RLPPPKSALSAPRKLEYNAGPHILSSPTHHQRQGLPRPLVNSAPNTPTAS 1151
                           ||...|:.....:.||.....  |...||         :.:|...|...|
Zfish   646 HTSLENLSGEDSETKRLRTVKNIADLRQNLEETMSS--LRGTTH---------ISHSTLETTFDS 699

  Fly  1152 PNKFHTIPSKIVG----TIYE------SKEEQLLPAPPPASGGSSILPMRPLLRGYNSHVTLPTR 1206
                 ||.::|.|    |:..      |...:|.....|:|..:.|           .| |.|.:
Zfish   700 -----TITTEINGRALLTLSSCPWRLGSSSPRLQAGEAPSSSNTFI-----------QH-TNPQQ 747

  Fly  1207 GARGGHHPHQSYLDFCESDIGQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGLNGPSSSAG 1271
            ....|....:. ::..|:   .||.||||.|  |.|   .|...|.:|||::|  |||       
Zfish   748 ACAHGLQLSEK-VEELET---PGYRSDGDVL--GKS---IRLDGITSGYLTDG--GLN------- 794

  Fly  1272 GISPGKHFLSMMRARTQLPTTIEERIRNSRGSLDSIGTAANGSSAA---SQASSSGGSTTTHAQN 1333
                    |...||.:|    :.:.:...||::......:...:.:   |.:.|||.|.|.....
Zfish   795 --------LYSRRANSQ----VLDGMNAGRGNIQHFNPKSQDDTDSWDDSSSVSSGISDTLDTDE 847

  Fly  1334 NNNNNN----NNSGGGAKMD-------GSPHHRPGSRNGRDNWS----KMPEPLNGQKVE----- 1378
            .|.:::    .|:..|.:.|       .:..|....:|  .:||    |..|..:|.|:|     
Zfish   848 LNTSSSLSSFVNTPSGPQRDTDEQLQTDAEKHSAVKQN--PSWSDKDLKRVELDSGVKMETTTKW 910

  Fly  1379 --KSDKSSPSRRSMGGGGSGSSSKQGS---------PSSSSRTKGV------------------- 1413
              :||.|..|.||:.|..:.:.|:.||         ..:|.|||..                   
Zfish   911 NNRSDFSDESERSLIGRKTPTISQTGSWRRGMSAQVGITSPRTKTTTSSNCNTLKTHGKTDDAKV 975

  Fly  1414 -------------------PP----------SFGYVKRANGSIASTAEQQNIAMMMAAGGAGANG 1449
                               ||          :||: |:|.|::|:         :.|:|....:|
Zfish   976 SEKGRSNSTHSITVDDSKKPPLNSTARTPTSTFGF-KKAPGTMAT---------ITASGAVVTSG 1030

  Fly  1450 LPCGRTAHVSAVPRTA--SGRKVAGGTQTLPNDMNKLPPNT----QHRSFSLTGPTATQLSQ-SI 1507
                 :|.|..:|::.  ||.:: |..||..:| ..|||:.    |:|  ||..|:.|..:: |.
Zfish  1031 -----SATVGKIPKSVGFSGSRI-GCRQTAVDD-GYLPPSARTTLQYR--SLPRPSRTSATRCSN 1086

  Fly  1508 RERLAT--------GSHSLPKPGSDLHVFQHRISNRGGT-----RHDGSLSDT------------ 1547
            |..::.        .:.:||.|.|     ::.:.:..|.     |..|..||.            
Zfish  1087 RPNISNFDSNFCNKSTATLPNPKS-----RNLVKSPVGATNQTDREKGIFSDVDNQVLKTSQSGM 1146

  Fly  1548 QTYAEVKPEYSSYAMWLKHSNTAGSRLSDGES---------VEQLQ----IGSPALTR------- 1592
            ||..:...:|.      :.|:....||..|:|         :|.::    |.:|..|.       
Zfish  1147 QTGRQTGGKYP------EMSSPTFRRLFGGKSCNKQVPVTTMENMKNSTVISNPHATSTQQNGSL 1205

  Fly  1593 ---------------------HGHKMIHNRSGGPGQMA---GQMSGNESPYVQSPR--------- 1624
                                 ||.:.:.:....||...   |..:|.:.|...|..         
Zfish  1206 DSKSVASGPDYGENLTVPSGGHGEQTLSSVISSPGSAFSPWGGKAGLDFPSQSSNHTNSDSIDVC 1270

  Fly  1625 -------MNRSNSIRSTKSEKMY--------------PSMMSRAGEV-------EIEPYYCLPVG 1661
                   :||.||.|:..|:..:              |....|.|.|       |...:      
Zfish  1271 LGKEDLCLNRVNSARTGLSDSPHSSPSASPKFTHNTLPRKQDRYGHVPQIRGHEEARDW------ 1329

  Fly  1662 TNGVLTAQMAAAMAAQSQAAQGNPGVGVNVGGVAWSQPTSPTPLTRGPFNTAAGASVLSPTHGT- 1725
                |.:..|..:...:.::..||       ..|.|.|:.    ||..|||..     |||..: 
Zfish  1330 ----LRSPTAVGLQDSTSSSPYNP-------ASALSSPSG----TRFNFNTLG-----SPTTSSQ 1374

  Fly  1726 -TSAAGLVGPGGGAGG------GAMVGHRLTYPKKN-------------DEVHGSAASLLSGGSS 1770
             |:..|:.|.|.....      ..:....::..::|             :|||||..||:|..||
Zfish  1375 ITALRGINGHGNHESSFEPYIDPRLRNSSMSLEERNRTMSSSGSFREGLEEVHGSCLSLVSSTSS 1439

  Fly  1771 LYGNAEERQAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERK 1835
            :|...||:...|||:|:|||..::::|.:|::|||.|||:|.||||||.|||.||..||.|||:|
Zfish  1440 VYSTPEEKAQTEIRKLRRELDASQEKVSALTTQLSANAHLVAAFEQSLGNMTIRLQSLTTTAEQK 1504

  Fly  1836 DGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQ 1900
            |.||.|:|:|||||:||:                :..|..:.|     .:..|    :|..:..:
Zfish  1505 DTELNDLRKTIELLKKQN----------------SATQATING-----VINTP----EPTLTSRK 1544

  Fly  1901 RAINANNGS----MPLGMQRQHSTDSMCSLNSISS----GCSAAQDKNKANKKKGW---LRSSFT 1954
            .::::.|||    ..||:.||.|:||:.|:.|.:|    |.:...|.....|||.|   |||||.
Zfish  1545 VSLDSINGSPQSQRELGIYRQPSSDSVSSMTSATSHSSIGSNLELDSKNKKKKKNWVSELRSSFK 1609

  Fly  1955 KAFSRNAKISKTSRHVGHHHHHNHSQQELASGKLPLHNGHGEPLGLASLATQPAPPLPNSKQSS- 2018
            :||.:.......|.|.......:.|..  :|.||| :||          :|..:|.:.||..:| 
Zfish  1610 QAFGKKKSPKSASSHSDIEEMTDSSLP--SSPKLP-YNG----------STASSPMIRNSNSNSL 1661

  Fly  2019 ------PA------------KTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEAL 2065
                  ||            ::.:|...::.:|:    |...|..|:.:||:|::.|||||||||
Zfish  1662 PQLSSLPAHGPVWGCSSTSMRSASLARISECMDS----DAETVMQLRSELRDKEMKLTDIRLEAL 1722

  Fly  2066 SSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVAGSSEVSRR 2130
            |||.||:.|:|.||:|:.|:..||..|:|| ||.:..|  ||.|:...:|||: ||..||::|  
Zfish  1723 SSAHQLDQLRESMNRMQIEVERLKVENDRL-KLESRGS--GSRAASQMSISPS-SVGLSSQLS-- 1781

  Fly  2131 YSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPA 2195
                                                              |:.||.:|:.     
Zfish  1782 --------------------------------------------------LTESTSLDML----- 1791

  Fly  2196 LEAAPMASPVHMASATEELADVCDGK--------KIAIACYLGQPEAFAKYCEELQELDGFYANG 2252
                              |.|..||.        |:.::.                         
Zfish  1792 ------------------LEDSGDGSSWKEGQHVKVVVSL------------------------- 1813

  Fly  2253 HEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNTD 2317
             |.|.:.:.|.:.       ::|::.|..:||||.|:.||.|||:.||:|:..:||.|.||||||
Zfish  1814 -EKDPEWKEECRP-------SQFLLGCIGVSGKTKWEVLDGVVRRLFKEYIICVDPVTQLGLNTD 1870

  Fly  2318 SITSYHLGEAKRGPEMGFPELLPCGYIVG-----SVRTLYICLQGVGSLAFDSLIPRSIVHRYIS 2377
            ::..|.:|:..|..:...||||||||:||     |||...:.:....||||::|||:.::.||||
Zfish  1871 TVMEYSIGDIHRASDADTPELLPCGYLVGESDTISVRLKDLSVDSEDSLAFETLIPKPVLQRYIS 1935

  Fly  2378 LLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAEQ 2442
            .|.||||:|..||||||||:||.||||.:|.|..:....::|||||||:|::|:|:|||..:|:|
Zfish  1936 QLEEHRRIIFSGPSGTGKSFLASRLAECMVLREGKQLDHQSIATFNVDNKTTKELKQYLSSLADQ 2000

  Fly  2443 AAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNFR 2507
            .......:::|.|:|||||||.::|.|:|:.||:. .:...|.|||||:|....|.|||||||||
Zfish  2001 CKNIVESADVPVVLILDNLHHVASLADIFNGLLNC-KSQHCPYIIGTMNQTPSPTPNLQLHHNFR 2064

  Fly  2508 WVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVTI 2572
            |:|.|||.|||||||||||||:|.:.|:.::....||..::.|:||||.|:|||||.||||||||
Zfish  2065 WILCANHTEPVKGFLGRFLRRKLLETEINSRVRNGELVKIIEWIPSVWHHLNRFLETHSSSDVTI 2129

  Fly  2573 GPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPYG 2637
            ||||||:||||::.|:|||||:|||.:.||::||||||:|:|||: .:|.||:.::..|:||...
Zfish  2130 GPRLFLSCPMDVEGSRVWFTDLWNYSIIPYMLEAVREGLQMYGRK-ASWEDPAKWVMESFPWVAS 2193

  Fly  2638 PDSVP--PLRQINAEDVGLEGVALTN----GDQ-------QDPLLNMLMRLQEAANYSEAQDQES 2689
            |....  .|.::..||||.:|..::.    |.|       :|||:|||:||:|.|:.:..:..:|
Zfish  2194 PQQHEWHSLLRLRPEDVGFDGYTISQEGSPGKQPAQGKPEEDPLMNMLLRLKETAHCAGTESYDS 2258

  Fly  2690 DCAS-------LDSNVTPESS 2703
            |..:       :||::  |||
Zfish  2259 DSTNNSHQDDMIDSSL--ESS 2277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479 42/101 (42%)
AAA 2382..2531 CDD:214640 84/148 (57%)
AAA_22 2385..2476 CDD:290137 45/90 (50%)
nav2bXP_021326321.1 CH 75..178 CDD:306753 44/103 (43%)
SH3_and_anchor <1446..>1527 CDD:275056 46/96 (48%)
AAA 1940..2057 CDD:214640 57/117 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 368 1.000 Domainoid score I867
eggNOG 1 0.900 - - E1_2CMAI
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 780 1.000 Inparanoid score I507
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 1 1.000 - - otm24695
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - O PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X908
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.950

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