DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and Nav3

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:NP_001074504.1 Gene:Nav3 / 260315 MGIID:2183703 Length:2366 Species:Mus musculus


Alignment Length:2668 Identity:742/2668 - (27%)
Similarity:1088/2668 - (40%) Gaps:779/2668 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   480 PVPSRHVQYKIR-KPRPLSTHSDADSGFLSPCSPEEMRANPAILVLQQCD-----SVQGY----- 533
            |:|:..:....| ..|||..           .:||....:..:.:...|:     ::||.     
Mouse    25 PIPNLGISVSRRCSSRPLEF-----------ATPERSMLSCQLTLKSTCEFGEKKALQGTAKEIE 78

  Fly   534 -MEIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKPKNQQQMFDNVN 597
             .:|||||||:||.::..||.:.||..|..||:|||::|:.:.:.||.|:...|::|.||.:||:
Mouse    79 DSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLADIIQIIANEKVEDINGCPRSQSQMIENVD 143

  Fly   598 SCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQAKQTKSIGVGCGGGVGGSSSTL 662
            .||..|.::.| .::.::..:|..|.|||:|.|||:|||:|||....:..               
Mouse   144 VCLSFLAARGV-NVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQY--------------- 192

  Fly   663 TGSGSVLGIGIGGLRTPGSSLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMVNRQIAPAYAKV 727
              ..|::.:   ..|...::...:.:|.:.||..|...|.:..|||..:|       ||.:..| 
Mouse   193 --YQSLVEL---QQRVTHTAPQSEASQAKTQQDMQSSLTARYAAQSKHSG-------IATSQKK- 244

  Fly   728 NGGTAIPLPATVMVQRRCPPDKVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPP--TSNHTIQS 790
              .|.:|.|:.|            |...:.|.......|.:....||:...|.||  .:.:...|
Mouse   245 --PTRLPGPSRV------------PAASSSNKAQGASNLNRRSQSFNSIDKNKPPNYANGNEKDS 295

  Fly   791 LK-----SGNNNSLRPPSIK-----SGIPSPS--------------------------SPQTAP- 818
            .|     ||.|.:.:|||..     |.|||||                          ||.|:| 
Mouse   296 PKGPQPSSGINGNTQPPSTSGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQPSPATSPT 360

  Fly   819 --------------------QKHSMLDKLKLFNKEKQQNAVNAASVASKTQIQSKRTSSSSGFSS 863
                                || |||:|.||.|              ::|.::..:..||.....
Mouse   361 PSSDRLKPPVTEGVKSAPSGQK-SMLEKFKLVN--------------ARTALRPPQAPSSGPNDG 410

  Fly   864 ARSERSDSSLSLNDGHGSQLKPPSISVSSQKPQPKTKQSKLLAAQQKKEQANKATKLDKKEK-SP 927
            .|.:.:.|.....:|..|.|.....:.||.|..||....|    ...|..:||.:.|..||| ..
Mouse   411 GREDDAFSESGEMEGFNSGLNSGGSTNSSPKVSPKLTPPK----AGSKNFSNKKSLLQPKEKEEK 471

  Fly   928 ARSLNK---EESGNES---------------------RSSTMGRTGKSSLVRAVGGVEK-----N 963
            .|..||   |:||.|.                     :.|......|.||:.:..|:.|     .
Mouse   472 TRDKNKACAEKSGKEEKDQVTTEAAPKKTSKIASLIPKGSKTAAAKKESLIPSSSGIPKPGSKVP 536

  Fly   964 TPK-TSSKSSLHSKSDSKSSLKAPQLLQSPSSGGLPKPIAAIKGTSKLPSL-------------- 1013
            ||| |.|..|..||...|.     :..:..||...||.|.|.|.::  |||              
Mouse   537 TPKQTISPGSAASKESEKF-----RTSKGSSSQAFPKAITAEKAST--PSLSTPLDGREAGQASP 594

  Fly  1014 ----------------GGGAGHLPAAESQQNQQLLKRETSDISSNISQPPPAEPPISTHAHIHQN 1062
                            |.||..||     |.||.....|:.::           |....||....
Mouse   595 SSSCVMQVTHSSGQSPGNGAVQLP-----QQQQHSHPNTATVA-----------PFIYRAHSENE 643

  Fly  1063 QTPPPPYYANSQPTSHISSHGFLSEPSTPQHSSGIYGSSRLPPPKSALSAPRKLEY--------- 1118
            .|..||..:.:.||...||:...::....:.|.....:.|:...|:.....:.||.         
Mouse   644 GTSLPPADSCTSPTKMDSSYSKTAKQCLEEISGEDPEARRMRTVKNIADLRQNLEETMSSLRGTQ 708

  Fly  1119 --------------------NAGPHILSSP---THHQRQGLPRPLVNSAPN-----TPTASPNKF 1155
                                .|.|::.|.|   |....|..||.....||:     :.:.:....
Mouse   709 ISHSTLETTFDTTVTTEVNGRAIPNLTSRPSPMTWRLGQACPRLQAGDAPSMGAGYSRSGTSRFI 773

  Fly  1156 HTIPSKIVGTIYESKEEQLLPAPPPASGGSSILPMRPLLR------GYNSHVTLPTRGARGGHHP 1214
            ||.||:.:.|                         .||.|      |..|.:.:..:.:      
Mouse   774 HTDPSRFMYT-------------------------TPLRRAAVSRLGNMSQIDMSEKAS------ 807

  Fly  1215 HQSYLDF-CESDIGQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGLN-------------- 1264
              |.||. .|.|:| ||.||||.|  |.|   .|..||::||:::|  |||              
Mouse   808 --SDLDVSSEVDVG-GYMSDGDIL--GKS---LRADDINSGYMTDG--GLNLYTRSLNRVPDTAT 862

  Fly  1265 --------------------GPSSSAGGISPGKHFLSM------------------MRARTQLPT 1291
                                ..||.:.|:|.....:|.                  .|..|||.|
Mouse   863 SRDVIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSISSYSNITVPSRKNTQLKT 927

  Fly  1292 TIEER------------IRNSRGSLDSIGTAA----NGSSAASQASSSGG--STTTHAQNNNNNN 1338
            ..|:|            ::.:.|..||.|..|    ..:|..::.|...|  ::.:.:|..:...
Mouse   928 DAEKRSTTDETWDSPEELKKAEGDCDSHGDGAAKWKGATSGLAEDSEKTGQKASLSVSQTGSWRR 992

  Fly  1339 NNNSGGGA------KMDGSPHHRPGSRNGRDNWSKMPEPLNGQKVEKSDKSSPSRRSMGGGGSGS 1397
            ..::.||.      |...|....||..:......|...||.|..:::|  .|.:.:|.|..|...
Mouse   993 GMSAQGGTPATARQKTSTSALKTPGKTDDAKASEKGKTPLKGSSLQRS--PSDAGKSSGDEGKKP 1055

  Fly  1398 SSKQGSPSSSSRTKGVPPSFGYVKRANGSIASTAEQQNIAMMMAAGGAGANGLPCGRTAHVSAVP 1462
            .|..|..::||       |||| |:.:|..|||       |:.::|....:|     :|.:..:|
Mouse  1056 PSGIGRSTASS-------SFGY-KKPSGVGAST-------MITSSGATITSG-----SATLGKIP 1100

  Fly  1463 RTAS--GRKVAGGTQTLPNDMNK----------------------------LPPNTQHRS----- 1492
            ::|:  |:..||...:|....|:                            :|....|||     
Mouse  1101 KSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSSTSGIPGRGGHRSSTSSI 1165

  Fly  1493 -FSLTGPTATQLSQSIRERLATGS-HSLPKP--GSDLHVFQHRISNRGGTRHDGSLSDTQTYAEV 1553
             .:::..:|...:..:||....|| .|.|..  .:|....:..:|:.......||...:.|.|..
Mouse  1166 DSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASA 1230

  Fly  1554 ------------KPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIG------SPALTRHGHKMIHN 1600
                        .|:.:|..........||.:.:...:.|..:..      |.:|.|.|  .:.:
Mouse  1231 CGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKSASAPNTEGAKSSSVVLSPSTSLARQG--SLES 1293

  Fly  1601 RSGGPGQM--AGQMSGNESPYVQSP-------------------------------RMNRSNSIR 1632
            .|.|.|.|  ||.:||:.||....|                               ..|.|:|..
Mouse  1294 PSSGTGSMGSAGGLSGSSSPLFNKPSDLTTDVISLSHSLASSPASVHSFTSGGLVWAANLSSSSA 1358

  Fly  1633 STKSEKMYPSMMS-RAGEVEIEPYYCLPVGTNGVL----------------TAQMAAAMAAQSQA 1680
            .:|....|.||.| ......|:    ||:..:|.|                |..:.:.::...|.
Mouse  1359 GSKDTPSYQSMTSLHTSSESID----LPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQL 1419

  Fly  1681 AQGN-PGVGVNV----------GGVAWSQPTSPTPLTRGPFNTAAGASVLSPTHGTTSAAG---- 1730
            .:.. |..|:..          .|..|.:..|    |.|..:|...:.::||:..::||.|    
Mouse  1420 DRNTLPKKGLRYTPSSRQANQEEGKEWLRSHS----TGGLQDTGNQSPLVSPSAMSSSATGKYHF 1480

  Fly  1731 --LVGPG----------------------------------GGAGG----GAMVGHRLTYPKKND 1755
              ||.|.                                  |.|..    ...|.|..::....:
Mouse  1481 SNLVSPTNLSQFNLPAPSMMRSSSIPAQDSSFDLYDDAQLCGSATSLEERPRAVSHSGSFRDSME 1545

  Fly  1756 EVHGSAASLLSGGSSLYGNAEERQAH--EIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSL 1818
            |||||:.||:|..||||..|||: ||  :|.:|:|||..::::|.:|:||||.|||:|.|||:||
Mouse  1546 EVHGSSLSLVSSTSSLYSTAEEK-AHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSL 1609

  Fly  1819 SNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQ 1883
            .|||.||..||.|||:|:.||.::|:|||:|:.|:..|                |..:||     
Mouse  1610 GNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAA----------------QAAIQG----- 1653

  Fly  1884 ALGQPGSDQKPPNSGSQRAINANNGSMPLGMQRQHSTDSMCSLNSISSGCSAAQDK---NKANKK 1945
            ||..|   ..||..              |.::||||::|:.|:||.:|..|.....   :|..||
Mouse  1654 ALNGP---DHPPKD--------------LRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKK 1701

  Fly  1946 KGW-------LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQELASGKLPLHNGHGEPLGLASL 2003
            |.|       |||||.:||.:.......|.|        ...:||....||              
Mouse  1702 KNWVNSRGSELRSSFKQAFGKKKSTKPPSSH--------SDIEELTDSSLP-------------- 1744

  Fly  2004 ATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEALSSA 2068
               .:|.||::...|.:.::....:|..|....:.:..::..||.:||||:|.||||||||||||
Mouse  1745 ---ASPKLPHNAGESGSSSMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSA 1806

  Fly  2069 SQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVAGSSEVSRRYSL 2133
            ..|:.::|.||:|:.|:..||..|:||      ::..|:.|...:..|.:.|.|.||...:...|
Mouse  1807 HHLDQIREAMNRMQNEIEILKAENDRL------KAETGNTAKPARPPSDSSSTASSSSSRQSLGL 1865

  Fly  2134 ADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEA 2198
            :.:|    :.:...::.::.|::                                          
Mouse  1866 SLNN----LNITESVTSDILLDD------------------------------------------ 1884

  Fly  2199 APMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYANGHEADSQSQSER 2263
                        |.:.....||:.:.|...:.:               |:   |...|.:||:  
Mouse  1885 ------------TGDATGHKDGRSVKIIVSISK---------------GY---GRAKDQKSQA-- 1917

  Fly  2264 KSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAK 2328
                       ::|....:||||.|..||.|:|:.||:||.|||..::|||::|.|.||.:|:..
Mouse  1918 -----------YLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSSSLGLSSDCIASYCIGDLI 1971

  Fly  2329 RGPEMGFPELLPCGYIVGSVRTLYICLQGV-----GSLAFDSLIPRSIVHRYISLLTEHRRLILC 2388
            |...:..||||||||:||....:.:.|:||     .|..||:|||:.|..||.:||.||.|:||.
Mouse  1972 RSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILS 2036

  Fly  2389 GPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELP 2453
            |||||||:|||.:|||:::.:|.|....:|||||||||||||:|:|||.::|||.:..|...|||
Mouse  2037 GPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGVELP 2101

  Fly  2454 SVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPV 2518
            .|||||||||..:|.|:|:..|:. ..||.|.|||||:|...::.||:|||||||||.|||.|||
Mouse  2102 VVIILDNLHHVGSLSDIFNGFLNC-KYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPV 2165

  Fly  2519 KGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMD 2583
            ||||||:|||:|.::|::......:|..::.|:|..|.|:|.|||.||||||||||||||.||||
Mouse  2166 KGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMD 2230

  Fly  2584 LKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPYG--PDSVPPLRQ 2646
            ::.|:|||.|:|||.|.||::||||||:|:||:| ..|.|||.::.::|||...  |...|.|.|
Mouse  2231 VEGSRVWFMDLWNYSLVPYVLEAVREGLQMYGKR-APWEDPSKWVLDTYPWSSASLPQEGPALLQ 2294

  Fly  2647 INAEDVGLEGVALT-----------NGDQQDPLLNMLMRLQEAANYSEAQDQESDCAS-----LD 2695
            :..||||.|....|           ...:.|||:||||:|||||||...|..:.|..|     ||
Mouse  2295 LRPEDVGYEACTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYPSTQSCDGDSVSHREDILD 2359

  Fly  2696 SNV 2698
            :::
Mouse  2360 TSI 2362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479 44/101 (44%)
AAA 2382..2531 CDD:214640 91/148 (61%)
AAA_22 2385..2476 CDD:290137 53/90 (59%)
Nav3NP_001074504.1 CH 81..182 CDD:237981 44/101 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..623 111/471 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 641..660 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..1315 96/460 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1413..1472 11/62 (18%)
PRKG1_interact 1775..1838 CDD:292521 30/68 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1836..1862 7/25 (28%)
P-loop_NTPase 2017..>2047 CDD:304359 18/29 (62%)
AAA 2030..2150 CDD:214640 67/120 (56%)
AAA 2033..>2113 CDD:99707 50/79 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 178 1.000 Domainoid score I3565
eggNOG 1 0.900 - - E1_2CMAI
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 696 1.000 Inparanoid score I677
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 1 1.000 - - otm43206
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - LDO PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3248
SonicParanoid 1 1.000 - - X908
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.980

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