DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sick and Nav1

DIOPT Version :9

Sequence 1:	NP_001260606.1	Gene:	sick / 35277	FlyBaseID:	FBgn0263873	Length:	2707	Species:	Drosophila melanogaster
Sequence 2:	XP_006529432.1	Gene:	Nav1 / 215690	MGIID:	2183683	Length:	2175	Species:	Mus musculus

Alignment Length:	2422	Identity:	619/2422 - (25%)
Similarity:	953/2422 - (39%)	Gaps:	696/2422 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 LRTPGSSLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMVNRQIAPAYAKVNGGTAIPLPATVM 740
            :.|||:|     .|...:||.....:||:.|........:.:|..:|...:..|......||..:
Mouse    47 IHTPGAS-----PQLRPRQQADLALSPQRGASPRRGKAAVSSRNSSPKAYRGRGTPRAAGPAREL 106

  Fly   741 VQRRCPPDKVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPPTS-NHTIQSLKSGNNNSLRPPSI 804
            .      ..|..||.:|.::|.:                :|.|: :....|.::|...|.:....
Mouse   107 A------GSVESLPSSPWNSPRV----------------TPKTALSSQAGSRRAGETQSTQRKKT 149

  Fly   805 KSGIP-----SPSSPQTA---------PQKHSM------LDKLKLFNK-----EKQQNAVNAASV 844
            :.|||     ..|.||::         |.:..|      .|:..:.:|     |..:...:..|.
Mouse   150 QEGIPVRHTRGRSPPQSSCYGETQIPGPPEGRMPPGCQGKDQRNIISKPPRCLEPDEGEASGTSS 214

  Fly   845 ASKTQIQSKRTSSSSG---FSSARSE--------------------------------------- 867
            ...:.:||.|:|::.|   ||||..:
Mouse   215 PVCSPVQSMRSSATPGVISFSSAHPQSQPITATVAPFQYRLQTDQEPGPVPQESWVLDGYTSPPS 279

  Fly   868 RSDSSLSLNDGH-----------GSQLK--PPSISVSSQKPQPKTKQSKLLAAQQKKEQANKATK 919
            |::.|.|..|..           ||.:|  .|.:.:|........:     .|.:.:..:.||..
Mouse   280 RTEDSFSCMDARIVHALLAGRMLGSSVKSVQPEVELSGGSGSGGDE-----GADESRGASRKAAA 339

  Fly   920 LDKKEKSPARSLNKEESGNESRSSTMG-RTGKSSLV--RAVGGV-EKNTPKTSSKSSLHSKSDSK 980
            .|.:...|.|:.....||:.:::|... :..||..|  |..||: ..|..|..|.::|...:||:
Mouse   340 ADGRGMLPKRAKAAGGSGSMAKASAAELKVFKSGSVDSRVPGGLPTSNLRKQKSLTNLSFLTDSE 404

  Fly   981 SSLKAPQLLQSPSSGGLPKPIAAIKGTSKLPSLGGGAGHLPAAESQQNQQLLKRETSDISSNISQ 1045
            ..|   ||.:...|..:.|   |.||..||...|            :...|:.:..|....::.|
Mouse   405 KKL---QLYEPEWSDDMAK---APKGLGKLGPKG------------RETPLMSKTLSKSEHSLFQ 451

  Fly  1046 P------------PPAEPPISTHAHIHQNQTPPPPYY----ANSQPTSHISSHG-----FLSEPS 1089
            |            .|..|.:...:.|     |..||.    .:..|.:.:|..|     .||..:
Mouse   452 PKGGSTGGAKTPLAPLAPSLGKPSRI-----PRGPYAEVKPLSKAPEAAVSDDGKSDDELLSSKA 511

  Fly  1090 TPQHSSGIYGS-----------------------------SRLPPPKS--------ALSAPRKLE 1117
            ..|..||...|                             |::..|:|        .|...:.||
Mouse   512 KAQKGSGTVPSAKGQEERAFLKVDPELVVTVLGDLEQLLFSQMLDPESQRKRTVQNVLDLRQNLE 576

  Fly  1118 YNAGPHILSSPTHHQRQGLPRPLVNS---APNTPTASPNKFHTIPSKIVGTIYESKEEQLLPAPP 1179
            ........|..||   ..|..|..:|   .|.:.::..|:     |..:...|.....:|.....
Mouse   577 ETMSSLRGSQVTH---SSLEMPCYDSDDANPRSVSSLSNR-----SSPLSWRYGQSSPRLQAGDA 633

  Fly  1180 PASGGS--SILPMRPLLRGYNSHV--TLPTRGARGGHHPHQSYLDFCES------DIGQGYCSDG 1234
            |:.|||  |..|....:.|..:|.  |:|.|..  ....|.|.|:..||      |:..||.||.
Mouse   634 PSVGGSCRSEGPPAWYMHGERAHYSHTMPMRSP--SKLSHISRLELVESLDSDEVDLKSGYMSDS 696

  Fly  1235 DALRVGSSPGGSRFHDIDNGYLSEGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPTTIEERIRN 1299
            |.:  |.:.  :...||..|: .|.||..:|.|.::..:|..:  .:...:...||||.....|:
Mouse   697 DLM--GKTM--TEDDDITTGW-DESSSISSGLSDASDNLSSEE--FNASSSLNSLPTTPTASRRS 754

  Fly  1300 S----RGSLDSIGTAANGSSAASQAS---------SSG------GSTTTHAQNNNNNNNNNSGGG 1345
            |    |...:....|.:|.:..|::.         .||      |::....:...:.::.:.||.
Mouse   755 STIVLRTDSEKRSLAESGLNWFSESEEKTPKKLEYDSGSLKMEPGTSKWRRERPESCDDASKGGE 819

  Fly  1346 AKMDGSPHHRPGS-RNGRDNWSKMPEPL--------------NGQKVEKSD---KSSPSRRSMGG 1392
            .|...|..| ||| :.|:.....:..|:              .|:..:|..   |::..:||...
Mouse   820 LKKPISLGH-PGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSD 883

  Fly  1393 GGSGSSSKQGSPSSSSRTKGVPPSFGYVK--RANGSIASTAEQQNIAMMMAAGGAG-------AN 1448
            .|....|....|.|.........||||.|  .|.|:          |.:|..|.:.       ::
Mouse   884 AGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGT----------ATVMQTGSSATLSKIQKSS 938

  Fly  1449 GLPCGRTAHVSAVPRTASGRKVAGGTQTLPNDMNKLPPNTQHRSFSLTGPTATQLSQSIRER-LA 1512
            |:|.          :..:|||                             |:..:|.|:... ||
Mouse   939 GIPV----------KPVNGRK-----------------------------TSLDVSNSVEPGFLA 964

  Fly  1513 TGS------HSLPKPGSDLHVFQHRISNRGGTRH-----DGSLSDT------------------- 1547
            .|:      .|||:|.....:   .::.|||.|.     |.||..|
Mouse   965 PGARSNIQYRSLPRPAKSSSM---SVTGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPSKVASG 1026

  Fly  1548 --------QTYAEVKPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIGSPALTR------------ 1592
                    ||..| |.:..:.|:.|...|.:...:...||..:.|...|..|:
Mouse  1027 RSTPAPVNQTDRE-KEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPPATKLAELPPTPLRAT 1090

  Fly  1593 -----------------------------HGHKM--IH---NRSGGP------GQMAGQMSGNES 1617
                                         |..|:  :|   :.:|||      ...|..::.|.:
Mouse  1091 AKSFVKPPSLANLDKVNSNSLDLPSSSDTHASKVPDLHAPSSSTGGPLPSCFTPSPAPILNINSA 1155

  Fly  1618 PYVQSPRMNRSNSIRSTKSEKMYPSMMSRAGEVE--------------IEPYYCLPVGTNGVLTA 1668
            .:.|...:....|:  .|..:|||.:......:|              ..|....|...:...|.
Mouse  1156 SFSQGLELMSGFSV--PKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSAPIPTPPTAPSEEDTE 1218

  Fly  1669 QM---AAAMAAQSQAAQGN----PGVGV-----------------NVGGVAWS--QPTSPTPLTR 1707
            ::   .:..|.|..::|.:    |..|:                 ..||:..|  |...|:|...
Mouse  1219 ELPWSGSPRAGQLDSSQRDRNTLPKKGLRYQLQSQEETKERRHSHTAGGLPESDDQAELPSPPAL 1283

  Fly  1708 GPFNTAAG--ASVLSPTHGTT------------SAAGLVGPGGGAGGGAMVGHRLTYPK------ 1752
            ....:|.|  .:::|||..||            .||..:..|...|....:..|   ||
Mouse  1284 SMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAER---PKGMIRSG 1345

  Fly  1753 ----KNDEVHGSAASLLSGGSSLYGNAEER-QAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVT 1812
                ..|:||||..||.|..||.|.:|||| |:.:||:|:|||:.::::|.:|:||||.||::|.
Mouse  1346 SFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVA 1410

  Fly  1813 AFEQSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQ 1877
            ||||||.|||:||..|..|||.||.||.|:|:||:.|:|::.:|                |..:|
Mouse  1411 AFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEA----------------QAVIQ 1459

  Fly  1878 GQALGQALGQPGSDQKPPNSGSQRAINANNGS-MPLGMQRQHSTDSMCSLNSISSGCSAAQDKN- 1940
            |                       |:||:..: ..|.::||:|:||:.|||||:|..|....|:
Mouse  1460 G-----------------------ALNASEATPKELRIKRQNSSDSISSLNSITSHSSIGSSKDA 1501

  Fly  1941 --KANKKKGW---LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQ-QELA--------SGKLPLH 1991
              |..|||.|   |||||.||||    |.|     |.....::|. :|:|        |.||.
Mouse  1502 DAKKKKKKSWVYELRSSFNKAFS----IKK-----GPKSASSYSDIEEIATPDSSAPSSPKLQ-- 1555

  Fly  1992 NGHGEPLGLASLATQPA-PPLPNSKQSSPAKTVT-----LIDNAKPIDAIDQE--DQHVVEDLKK 2048
              ||        :|:.| |.:.:|..||....||     .:.:.:...|.::|  ::..|.:|:.
Mouse  1556 --HG--------STETASPSIKSSTSSSVGTEVTETPAHSVPHTRLFQANEEEEPEKKEVSELRS 1610

  Fly  2049 QLREKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQ 2113
            :|.||::.|||||||||:||.||:.|:|.|:.|:.|:..||..|:||:       :|...:|
Mouse  1611 ELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLK-------VAPGPSS--- 1665

  Fly  2114 AISPNGSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSV 2178
            ..:| |.|.|||.:          |.|...|...||.
Mouse  1666 GCTP-GQVPGSSAL----------SSPRRSLGLALSH---------------------------- 1691

  Fly  2179 APLSPS-THVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEEL 2242
             |.||| |..||:|          ...:....:.||:.     .::.:..   .|:...|
Mouse  1692 -PFSPSLTDTDLSP----------MDGISTCGSKEEVT-----LRVVVRM---PPQHIIK----- 1732

  Fly  2243 QELDGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARID 2307
                        .|.:.|             ||.:.|:.:|||..|:.||..|.:.||||::::|
Mouse  1733 ------------GDLKQQ-------------EFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMD 1772

  Fly  2308 PGTNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQG-----VGSLAFDSLI 2367
            |.:.|||:|:||..|.|...||..:...||:.||.   ..|..:.:.|:|     |.||.|::||
Mouse  1773 PASTLGLSTESIHGYSLSHVKRVLDAEPPEMPPCR---RGVNNISVALKGLKEKCVDSLVFETLI 1834

  Fly  2368 PRSIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDL 2432
            |:.::..|||||.:||||:|.|||||||:||..||||:||.||.|......::|||:..:|.|||
Mouse  1835 PKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTDGIVSTFNMHQQSCKDL 1899

  Fly  2433 RQYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNT 2497
            :.||.::|.|.....|:.::|.||:||:|..|.::.::.:..|:. ..:|.|.||||.:|....|
Mouse  1900 QLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTC-KYHKCPYIIGTTNQPVKMT 1963

  Fly  2498 TNLQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFL 2562
            .|..||.:||.:..:|::||..|||.|:|||:|.:.:......:.||..||.|:|.:|.|::.||
Mouse  1964 PNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDVNANKEELLRVLDWVPKLWYHLHTFL 2028

  Fly  2563 EVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAF 2627
            |.||:||..|||..||:||:.::|.:.||.|:||..:.|||.|..::|::::|:: .||.||..:
Mouse  2029 EKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQK-AAWEDPVEW 2092

  Fly  2628 IRNSYPWPYGPDSVPPLRQINAEDVGLEGVA-----------LTNGDQQDPLLNMLMRLQEAANY 2681
            :|::.|||........|..:....||....|           ..|....|||:.||::|||||||
Mouse  2093 VRDTLPWPSAQQDQSKLYHLPPPSVGPHSTASPPEDRTVKDSTPNSLDSDPLMAMLLKLQEAANY 2157

  Fly  2682 SEAQDQESDCASLDSNV 2698
            .|:.|:|:   .||.|:
Mouse  2158 IESPDRET---ILDPNL 2171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH	535..637	CDD:214479
		AAA	2382..2531	CDD:214640	66/148 (45%)
		AAA_22	2385..2476	CDD:290137	39/90 (43%)
Nav1	XP_006529432.1	PHA03247	<27..277	CDD:223021	46/256 (18%)
		SMC_prok_B	<1377..>1461	CDD:274008	45/122 (37%)
		AAA	1848..1959	CDD:214640	49/111 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I677
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001074
OrthoInspector	1	1.000	-	-		otm43206
orthoMCL	1	0.900	-	-		OOG6_103597
Panther	1	1.100	-	-	O	PTHR12784
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X908
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050