Protein Alignment sick and unc-53

DIOPT Version :10

• Sequence 1: NP_001260606.1
• Gene: sick / 35277
• FlyBaseID: FBgn0263873
• Length: 2707
• Species: Drosophila melanogaster
• Sequence 2: NP_001022170.1
• Gene: unc-53 / 174693
• WormBaseID: WBGene00006788
• Length: 1654
• Species: Caenorhabditis elegans
• Alignment Length: 2252
• Identity: 494/2252 - (21%)
• Similarity: 775/2252 - (34%)
• Gaps: 775/2252 - (34%)

  Fly   536 IYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFK--VPDLVKKPKNQQQMFDNVNS 598
            |||||||.:|.:....:.:.|:|.|.||..|::::|..:....  .|...|:........|.:.:
 Worm    11 IYTDWANRHLSKGSLSKSIRDISNDFRDYRLVSQLINVIVPINEFSPAFTKRLAKITSNLDGLET 75

  Fly   599 CLHVLRSQSVGGLE--NITTNDICAGRLKAVLALFFALSRFKQQAKQTKSIGVGCGGGVGGSSST 661
            ||..|::.   ||:  .:|..||.:|.|.|||.|.|.||.:||:.:|.|.          .....
 Worm    76 CLDYLKNL---GLDCSKLTKTDIDSGNLGAVLQLLFLLSTYKQKLRQLKK----------DQKKL 127

  Fly   662 LTGSGSVLGIGIGGLRTP-------GSSLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMVNRQ 719
            .....|::...:..|.:|       .|:.|.:.|  ..|....:.||||.....:::....:.
 Worm   128 EQLPTSIMPPAVSKLPSPRVATSATASATNPNSN--FPQMSTSRLQTPQSRISKIDSSKIGIK-- 188

  Fly   720 IAPAYAKVNGGTAIPLPATVMVQRRCPPDKVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPPTS 784
                            |.|..::           ||:.:.|        |.::.|:.||:|..:.
 Worm   189 ----------------PKTSGLK-----------PPSSSTT--------SSNNTNSFRPSSRSSG 218

  Fly   785 NHTIQSLKSGNNNSLRPPSIKSGIPS----------PSSPQTAPQKHSMLDKLKLFNKEKQQNAV 839
            |:.:.|..|.:..||...|..|.|.:          ||.|||...:.:...|:. .:|.....||
 Worm   219 NNNVGSTISTSAKSLESSSTYSSISNLNRPTSQLQKPSRPQTQLVRVATTTKIG-SSKLAAPKAV 282

  Fly   840 NAASVASKTQIQSKRTSSSSGFSSARSERSDSSLSLNDGHGSQLK-----PPSISVSSQKPQPKT 899
            :...:||...|.:|:...:||                .|.|..||     ..:.|.||..|||..
 Worm   283 STPKLASVKTIGAKQEPDNSG----------------GGGGGMLKLKLFSSKNPSSSSNSPQPTR 331

  Fly   900 KQSKL--------LAAQQKK------EQANKATKLDK-------KEKSPARSLNKEESGNESRSS 943
            |.:.:        :||..|.      .:...||.:.|       ..|:.|..:::::|...|:||
 Worm   332 KAAAVPQQQTLSKIAAPVKSGLKPPTSKLGSATSMSKLCTPKVSYRKTDAPIISQQDSKRCSKSS 396

  Fly   944 --TMGRTGKSSLVRAVGGVEKNTPKTSSKS----SLHSKSDSKSSLKAPQLLQSPSSGGLP---- 998
              ..|..|.:|           |..|||.:    |:||.| ||||....   :||||..|.
 Worm   397 EEESGYAGFNS-----------TSPTSSSTEGSLSMHSTS-SKSSTSDE---KSPSSDDLTLNAS 446

  Fly   999 ------KPIAAIKGTSKLPSLGGGAGHLPAAESQQNQQLLKRETSDI----SSNISQPPPAEPPI 1053
                  :||||                .|.:.:..|:.:.::.|..:    |:....||||.||.
 Worm   447 IVTAIRQPIAA----------------TPVSPNIINKPVEEKPTLAVKGVKSTAKKDPPPAVPPR 495

  Fly  1054 STHAHIHQNQTPPPPYYANSQPT----SHISSH------GFLSEPSTPQHSSGIYGSSR----LP 1104
            .|                  |||    |.|.:|      ..:||...|:....:...:.    ||
 Worm   496 DT------------------QPTIGVVSPIMAHKKLTNDPVISEKPEPEKLQSMSIDTTDVPPLP 542

  Fly  1105 PPKSALSAPRKLEYNAGPHILSSPTHH--QRQGLPRPLVNSAPNTPTASPNKFHTIPSKIVGTIY 1167
            |.||.:  |.|:     ..|...||:.  .:||                  |. |.|.|..|...
 Worm   543 PLKSVV--PLKM-----TSIRQPPTYDVLLKQG------------------KI-TSPVKSFGYEQ 581

  Fly  1168 ESKEEQLLPAPPPASGGSSILPMRPLLRGYNSHVTLPTRGARGGHHPHQSYLDFCESDIGQGYCS 1232
            .|..|..:.|...|                  .||.||:  ..|:|..:..:...::....||.|
 Worm   582 SSASEDSIVAHASA------------------QVTPPTK--TSGNHSLERRMGKNKTSESSGYTS 626

  Fly  1233 D-GDALRVGSSPGGSRFHDI----DNGYLSEGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPTT 1292
            | |.|:..........:.|:    .|||    .......||.:.|||
 Worm   627 DAGVAMCAKMREKLKEYDDMTRRAQNGY----PDNFEDSSSLSSGIS------------------ 669

  Fly  1293 IEERIRNSRGSLDSIGT-AANGSSAASQASSSGGSTTTHAQNNNNNNNNNSGGGAKMDGSPHHRP 1356
                   ....||.|.| ..:|...|:.||
 Worm   670 -------DNNELDDISTDDLSGVDMATVAS----------------------------------- 692

  Fly  1357 GSRNGRDNWSKMPEPLNGQKVEKSDKSSPSRRSMGGGGSGSSSKQGSPSSSSRTKGVPPSFGYVK 1421
                                 :.||.|...|.               |:|||....||      .
 Worm   693 ---------------------KHSDYSHFVRH---------------PTSSSSKPRVP------S 715

  Fly  1422 RANGSI--ASTAEQQNIAMMMAAGGAGANGLPCGRTAHVSAVPRTASGRKVAGGTQTLPNDMNKL 1484
            |::.|:  .|.|||:|:..:::                     :..:.::.|..|.|.
 Worm   716 RSSTSVDSRSRAEQENVYKLLS---------------------QCRTSQRGAAATSTF------- 752

  Fly  1485 PPNTQHRSFSLTGPTATQLSQSIRERLATGSHSLPKPGSDLHVFQHRISNRGGTRHDGSLSDTQT 1549
                                         |.|||..||...:.....:|....|....|.:..:.
 Worm   753 -----------------------------GQHSLRSPGYSSYSPHLSVSADKDTMSMHSQTSRRP 788

  Fly  1550 YAEVKPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIGSPALTRHGHKMIHNRSGGPGQMAGQMSG 1614
            .:: ||.||...    ||......|.:..|.|             |:|....|  |.::...||.
 Worm   789 SSQ-KPSYSGQF----HSLDRKCHLQEFTSTE-------------HRMAALLS--PRRVPNSMSK 833

  Fly  1615 NESPYVQSPRMNRSNSIRSTKSEKMYPSMMSRAGEVEIEPYYCLPVGTNGVLTAQMAAAMAAQSQ 1679
            .:|   .:..:|.|...||.   .:..|:..|.......|      ..:.::||..:|...:.|
 Worm   834 YDS---SAAALNASGMSRSM---ILLESLSPRPPRRHQSP------ADSCIITASPSAPRRSHS- 885

  Fly  1680 AAQGNPGVGVNVGGVAWSQPTSPTPLTRGPFNTAAGASVLSPTH-----GTTSAAGLVGPGGGAG 1739
                               |..||  .|.|.:.|:     ||.|     |:.||....|...|..
 Worm   886 -------------------PRGPT--ARIPLSLAS-----SPVHVNNNWGSYSARSRGGSSTGIY 924

  Fly  1740 GGAMVGHRLTYPKK-----NDEVHGSAASLLSGGSSLYGNAEERQAHEIRRLKRELQDARDQVLS 1799
            |.....|||:..|.     ..|: ||..||.|  ::.||:..|:..|.||.:.|:|:..::.|.|
 Worm   925 GETFQLHRLSDEKSPAHSAKSEM-GSQLSLAS--TTAYGSLNEKYEHAIRDMARDLECYKNTVDS 986

  Fly  1800 LSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQ 1864
            |:.:......:...|||.|..:|..:.:    :..|..|....||.|..||..|......:||
 Worm   987 LTKKQENYGALFDLFEQKLRKLTQHIDR----SNLKPEEAIRFRQDIAHLRDISNHLASNSAH-- 1045

  Fly  1865 SMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRAINANNGSMPLGMQRQHSTDSMCSLNSI 1929
                                                    ||.|:..|  .||.|.:|:.|..|.
 Worm  1046 ----------------------------------------ANEGAGEL--LRQPSLESVASHRSS 1068

  Fly  1930 SSGCSAAQDKNK------ANKKKGWLRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQELASGKL 1988
            .|..|.:..:.|      ...||.|:|||.:|...:..|              |:.:..:
 Worm  1069 MSSSSKSSKQEKISLSSFGKNKKSWIRSSLSKFTKKKNK--------------NYDEAHM----- 1114

  Fly  1989 PLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREK 2053
                                |.:..|:.:        :||   ||.|         :||::|:|:
 Worm  1115 --------------------PSISGSQGT--------LDN---IDVI---------ELKQELKER 1139

  Fly  2054 DLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPN 2118
            |..|.::||:.|..|.:::.|:|.:||::.|...||...::|.....||  |.|.||
 Worm  1140 DSALYEVRLDNLDRAREVDVLRETVNKLKTENKQLKKEVDKLTNGPATR--ASSRAS-------- 1194

  Fly  2119 GSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSP 2183
                                     :|....:|...:..|...:.:.........|.:.|
 Worm  1195 -------------------------IPVIYDDEHVYDAACSSTSASQSSKRSSGCNSIKV----- 1229

  Fly  2184 STHVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGF 2248
            :.:||:                     ..|::.:.:..|..|..||..|
 Worm  1230 TVNVDI---------------------AGEISSIVNPDKEIIVGYLAMP---------------- 1257

  Fly  2249 YANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLG 2313
                               ||.||               |:::|..:...|:.|::|||....||
 Worm  1258 -------------------TSQSC---------------WKDIDVSILGLFEVYLSRIDVEHQLG 1288

  Fly  2314 LNT-DSITSYHLGEAKR--GPEMGFPELLPCGYIVGSVRTLYICLQG-----VGSLAFDSLIPRS 2370
            ::. |||..|.:||.:|  |.........|...:..|. |:.:.:.|     |.||..|.|:|:.
 Worm  1289 IDARDSILGYQIGELRRVIGDSTTMITSHPTDILTSST-TIRMFMHGAAQSRVDSLVLDMLLPKQ 1352

  Fly  2371 IVHRYI-SLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSE-AIATFNVDHKSSKDLR 2433
            ::.:.: |:||| |||:|.|.:|.|||.||:.||.::   |.|.|.|| :|...::...:.::|.
 Worm  1353 MILQLVKSILTE-RRLVLAGATGIGKSKLAKTLAAYV---SIRTNQSEDSIVNISIPENNKEELL 1413

  Fly  2434 QYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQ------ 2492
            |....:.:...     |:...::||||:                 |.|::..::...:.
 Worm  1414 QVERRLEKILR-----SKESCIVILDNI-----------------PKNRIAFVVSVFANVPLQNN 1456

  Fly  2493 ----ATCNTTN------LQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLE--LQTQHPQPELA 2545
                ..| |.|      ||:||||:..:.:|.:|   ||:.|:||||..:.|  |..|.|. ||.
 Worm  1457 EGPFVVC-TVNRYQIPELQIHHNFKMSVMSNRLE---GFILRYLRRRAVEDEYRLTVQMPS-ELF 1516

  Fly  2546 AVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREG 2610
            .::.:.|...|.:|.|:|..:|.|||:|||..|.||:.:..|:.||..:||.:..|||....|:|
 Worm  1517 KIIDFFPIALQAVNNFIEKTNSVDVTVGPRACLNCPLTVDGSREWFIRLWNENFIPYLERVARDG 1581

  Fly  2611 VQLYGRRGGAWNDPSAFIRNSYPWPYGPDSVPPLRQINAEDV 2652
            .:.:| |..::.||:..:...:||..|.:....|:::..:|:
 Worm  1582 KKTFG-RCTSFEDPTDIVSEKWPWFDGENPENVLKRLQLQDL 1622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH_NAV2-like	535..638	CDD:409061	35/105 (33%)
		PHA03247	<729..1182	CDD:223021	120/524 (23%)
		Atrophin-1	<985..>1182	CDD:460830	49/226 (22%)
		McrB	<2368..2597	CDD:441011	76/248 (31%)
unc-53	NP_001022170.1	CH_NAV2-like	8..114	CDD:409061	35/105 (33%)
		PHA03247	<436..622	CDD:223021	55/265 (21%)
		DivIC	1148..1205	CDD:428231	19/91 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1367..>1438	CDD:476819	24/95 (25%)