DRSC/TRiP Functional Genomics Resources

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Protein Alignment sick and nav1a

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:XP_009294910.1 Gene:nav1a / 100536287 ZFINID:ZDB-GENE-120920-3 Length:1485 Species:Danio rerio


Alignment Length:1992 Identity:524/1992 - (26%)
Similarity:793/1992 - (39%) Gaps:636/1992 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   780 SPPTSNHTIQSLKSGNN-NSLRPPSIKSGIPSPSSPQTAPQKHSMLDK-LKLFNKEKQQNAVNAA 842
            |..:.|.:.:...:|:: |||....|.|...|....:|..:|.|:::. |..:::|         
Zfish    40 SDGSDNLSSEEFNAGSSLNSLPTTPIGSRRNSAIVLRTDAEKRSLVESGLSWYSEE--------- 95

  Fly   843 SVASKTQIQ--------SKRTSSSSGFSSARSERSDSSLSLNDGHGSQLKPPSISVSSQKPQPKT 899
               .|||.|        |.:|..:|.:..:||: .|:::.     |...||.::.:...:..|..
Zfish    96 ---GKTQCQTDGVYDTGSLKTDLTSKWKKSRSQ-DDAAVK-----GELRKPQTLGLKKSRNPPVG 151

  Fly   900 KQSKLLAAQQKKEQANKATKLDKKEKSPARSLNKEESGNESRSSTMG------RTGKSSLVRAVG 958
            ..|.:..:.|...:.....|.|::....|:...| .||.:..||..|      |...|.|||...
Zfish   152 VTSPITHSSQSLLKVPGVPKNDQRVVDKAKMAVK-SSGLQRSSSDAGKDRGEHRKPPSGLVRPSA 215

  Fly   959 GV------EKNTPKTSSKSSLHSKSDSKSSLKAPQLLQSPSSGGLPKPIAAIKGTSKLPSLGGGA 1017
            |.      :||||.|.:.:.| :...:...:.:..:.::|.:.|:|     :|     ||.||| 
Zfish   216 GTTNSFGYKKNTPTTGTATVL-TTGPNTVPVDSTIVNKTPKTSGIP-----VK-----PSAGGG- 268

  Fly  1018 GHLPAAESQQNQQLLKRETSDISSNISQPPPAEPPISTHAHIHQNQTPPPPYYANSQPTSHISSH 1082
                            |:||...||..|                                     
Zfish   269 ----------------RKTSLDVSNCDQ------------------------------------- 280

  Fly  1083 GFLSEPSTPQHSSGIYGSSRLPPPKSALSAPRKLEYNAGPHILSSPTHHQRQGLPRP-------L 1140
            ||:                          ||     ||..:|       |.:.||||       |
Zfish   281 GFM--------------------------AP-----NARNNI-------QYRSLPRPAKTSTLSL 307

  Fly  1141 VNSAPNTPTASPN------KFHTIPSKIVGTIYESKEEQLLPAPPPASGGSSILPMRPLLRGYNS 1199
            ....|.....|.|      ...|:|:                            |.|....|.:|
Zfish   308 TGGRPGARPVSSNIDIGLQGLKTVPA----------------------------PSRLKEPGKSS 344

  Fly  1200 HVTLPTRGARGGHHPHQSYLDFCESDIGQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGLN 1264
            |     |.:.||..|........|....:...||.:.     ..|||    :.||.|:.......
Zfish   345 H-----RASTGGCTPVNQTDREKEKAKAKAVASDSEC-----GGGGS----LKNGTLTPTQCAPE 395

  Fly  1265 GPSSSAGGISP---GKHFLSMMRARTQLPTTIEERIRNSRG-----SLDSIGTAANGSSAASQAS 1321
            .||...|...|   ||:        ::||:....|..::|.     .|:.|            :|
Zfish   396 PPSKLLGLRQPSSLGKY--------SELPSPNSHRPSSARSLSKPPLLEKI------------SS 440

  Fly  1322 SSGGSTTTHAQNNNNNNNNNSGGGAKMDGSPHHRPGSRNGRDNWSKMPEPLNGQKVEKSDKSSPS 1386
            :|....||..:                |..|...|       .:||:|: |:||.:..|...:|:
Zfish   441 TSLECETTSPE----------------DHLPPKVP-------PYSKVPD-LSGQLISSSLSPTPA 481

  Fly  1387 RRSMGGGGSGSSSKQGSPSSSSRTKGVPPSFGYVKRANGSIASTAEQQNIAMMMAAGGAGANGLP 1451
            ...........||..||||...|..|:..|.              |..::.|.:...|.|     
Zfish   482 PVLSISSSQCFSSSSGSPSLYPRLSGLTRSM--------------ESLSLQMSVCPPGGG----- 527

  Fly  1452 CGRTAHVSAVPRTASGRKVAGGTQTLPNDMNKLPPNTQHRSFSLTGPTATQLSQSIRERLATGSH 1516
                    .|.|..||....|                 ..|.|||    |..||..|       :
Zfish   528 --------TVDRGVSGGWTNG-----------------RASLSLT----TDSSQKDR-------N 556

  Fly  1517 SLPKPGSDLHVFQHRISNRGGTRHDGSLSDTQTYAEVKPEYSSYAMWLKHSNTAGSRLSDGESVE 1581
            :|||.|....:......:....||..::. :.|.|...|:|.                       
Zfish   557 TLPKKGLSQQLLSQAEEDSKERRHSHTIM-SSTEASSPPQYP----------------------- 597

  Fly  1582 QLQIGSPALTRHGHKMIHNRSGGPGQMAGQMSGNESPYVQSPRMNRSNSIRSTKSEKMYPSMMSR 1646
                 .|:||   .|:.......|...:|           :|||.|||||.:             
Zfish   598 -----LPSLT---GKLPLTNIMSPSSTSG-----------TPRMTRSNSIPT------------- 630

  Fly  1647 AGEVEIEPYYCLPVGTNGVLTAQMAAAMAAQSQAAQGNPGVGVNVGGVAWSQPTSPTPLTRGPFN 1711
             .|...|.|...|:|:    |..:|                         .:|.|  .:..|.|.
Zfish   631 -HEASFELYQASPLGS----TLSLA-------------------------ERPKS--MIRSGSFR 663

  Fly  1712 TAAGASVLSPTHGTTSAAGLVGPGGGAGGGAMVGHRLTYPKKNDEVHGSAASLLSGGSSLYGNAE 1776
                                                   .:.||:||||..||:|..||.|.:||
Zfish   664 ---------------------------------------DRDNDDVHGSVLSLVSNASSSYSSAE 689

  Fly  1777 ER-QAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGELT 1840
            || |..:||:|:|||:.::::|..|::|||.||::|.||||||:.||:||..|:.:||:|||||.
Zfish   690 ERMQGEQIRKLRRELESSQEKVACLTTQLSANANLVAAFEQSLALMTSRLQTLSFSAEQKDGELI 754

  Fly  1841 DMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQ-ALGQPGSDQKPPNSGSQRAIN 1904
            ::::|||.|:.::::|                      ||:.| ||..|  |..|..        
Zfish   755 ELKETIESLKTKNMEA----------------------QAVIQVALNNP--DVAPKE-------- 787

  Fly  1905 ANNGSMPLGMQRQHSTDSMCSLNSISSGCS--AAQDKNKANKKKGWLRSSFTKAFS--RNAKISK 1965
                   |.::||:|::|:.|||||:|..|  :.:|..|..|||.||||||.||||  :.||...
Zfish   788 -------LRIRRQNSSESISSLNSITSHSSVGSLKDDAKKKKKKSWLRSSFGKAFSIKKGAKGGS 845

  Fly  1966 TSRHVGHHHHHNHSQQELA--------SGKLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKT 2022
            ....:          :|:|        |.||...:|...|..|.||             .|...:
Zfish   846 MYSDI----------EEIATPDSSAPNSPKLAHEDGENPPPSLQSL-------------QSAVSS 887

  Fly  2023 VTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMS 2087
            |.|..|.:     .:.|:.||.:|:.:|.||::.|||||||||:||.|||.|:|.||.|::.:.:
Zfish   888 VILESNEE-----TESDEKVVSELRSELWEKEMKLTDIRLEALNSAHQLEQLREAMNSMQSMVEN 947

  Fly  2088 LKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVAGS-SEVSRRYSLADSN-SRPPMELPARLSE 2150
            ||..|::|:        .||..|  ..:.|.|..:.| |:.|...||..|| ::|.|.|....| 
Zfish   948 LKAENDQLK--------TGSAPS--SLVLPCGPPSSSTSQPSGLASLMSSNQTKPAMSLTKSFS- 1001

  Fly  2151 ELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPVHMASATEELA 2215
             |.|.| |.                                                      .|
Zfish  1002 -LSLNE-CF------------------------------------------------------TA 1010

  Fly  2216 DVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYANGHEADSQSQSERKSNYTSASCNEFVIACT 2280
            ||...:.::.:|.  :.|.|.:....:            ||.|...|.:.       .:|.|...
Zfish  1011 DVAPVELLSASCQ--RDEVFTRVVVRI------------ADHQVSREARQ-------QDFYIGSV 1054

  Fly  2281 YISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIV 2345
            .|.|||.|..||..:...|:||::::|||.::||:.|||.||.:.:::|......||..||..:.
Zfish  1055 KIHGKTEWSTLDSDIATIFRDYISQLDPGASMGLSVDSIHSYSINQSRRVLGTEDPENSPCDCLQ 1119

  Fly  2346 GSVRTLYICLQG-----VGSLAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEF 2405
            .:...:.:.|:|     |.||.|::|||:.::..|||||.:||||:|.|||||||:||..||||:
Zfish  1120 AAPGLVTVTLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTTRLAEY 1184

  Fly  2406 LVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDV 2470
            |:.||.|...|..|.|||:..::.|||:.||.::|.|.....|..::|.|||||::..|:::.|:
Zfish  1185 LLERSGRDPSSGLINTFNMHQQTCKDLQLYLSNLANQIDRDCGTDDIPLVIILDDISDATSITDI 1249

  Fly  2471 FSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLEL 2535
            .:..|:. ..:|.|.:|||.:|:...::|..||.:||.:..:|::||..|||.|:|.|:|.:.|.
Zfish  1250 VNSALTC-KYHKCPYVIGTTNQSFKMSSNHGLHLSFRMITFSNNVEPANGFLVRYLHRKLIETEN 1313

  Fly  2536 QTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLS 2600
            .::....|:..||.|:|.:|.|::.|||.||:||..|||..||:||:.|.:.:.||.|:||..:.
Zfish  1314 NSKAHNSEVLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPVSLAEFRTWFIDLWNQSII 1378

  Fly  2601 PYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPYG------------PDSVP---PLRQINAE 2650
            |||.|..::||:::|:: .||.||..::|::.|||..            |.:.|   |.:|.|.|
Zfish  1379 PYLQEGAKDGVKVHGQK-AAWEDPVEWVRDTLPWPSAQQDQAKLFHLPPPTTCPNTAPAQQSNDE 1442

  Fly  2651 ----DVGLEGVALTNGDQQDPLLNMLMRLQEAANYSEAQDQE 2688
                |..|..:      :.|||:.||::|||:|||.|:.:::
Zfish  1443 RSHRDTALPTM------ESDPLMAMLLKLQESANYIESPERD 1478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479
AAA 2382..2531 CDD:214640 64/148 (43%)
AAA_22 2385..2476 CDD:290137 40/90 (44%)
nav1aXP_009294910.1 RILP-like <695..766 CDD:304877 36/70 (51%)
AAA 1160..1269 CDD:214640 49/109 (45%)
AAA 1164..>1240 CDD:99707 38/75 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 368 1.000 Domainoid score I867
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 1 1.000 - - otm24695
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - O PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X908
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
77.000

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