DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sick and nav1

DIOPT Version :9

Sequence 1:	NP_001260606.1	Gene:	sick / 35277	FlyBaseID:	FBgn0263873	Length:	2707	Species:	Drosophila melanogaster
Sequence 2:	XP_002932183.2	Gene:	nav1 / 100495951	XenbaseID:	XB-GENE-981217	Length:	1716	Species:	Xenopus tropicalis

Alignment Length:	2039	Identity:	554/2039 - (27%)
Similarity:	851/2039 - (41%)	Gaps:	551/2039 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   882 QLKPPSISVSSQK--------PQPKTKQSKLLAAQQKKEQA--NKATKLDKKEKSPARSLNKE-- 934
            ::||||.:|..:.        |.....:|:|..|..:::::  |.:...|.::|  .|....:
Frog     5 KVKPPSGAVPGRSAELRVFRGPTNAVHESRLPGAPLRRQRSLTNLSVLTDAEKK--LRLCGPDWC 67

  Fly   935 ---ESGNESRSSTMGRTGKSSLVRAVGGVEKNTPKTSSKSSLHSKSDSKSSLKAPQLLQSPSSGG 996
               .:.|.||                  ::...|.:.:.|...|:|:.       .|||..:...
Frog    68 DDLSAVNSSR------------------IQNAAPPSPAMSRALSRSEH-------SLLQPRTPSR 107

  Fly   997 LPK-PIAAIKGTSKL--PSLGGGAGHLPAAESQQNQQLLKRETSDI-------------SSNISQ 1045
            :|: |.|.:|..||.  ||.|..||..|..|:.::::...:...::             |..:..
Frog   108 IPRGPYAEVKPLSKAPEPSSGVPAGGDPGKEAAEDKKAFLKVDPELVVTVLGDLEQLLFSQMLDP 172

  Fly  1046 PPPAEPPISTHAHIHQNQTPPPPYYANSQPT-SHISSHGFLSEPSTPQHSSGIYGSSRLPPPKSA 1109
            ....:..:.....:.||..........||.| |.:....:.|:.:.|:..|.:  |:|
Frog   173 ETQRKRTVQNVLDLRQNLEDTMSSLRGSQVTHSSLDMPCYDSDDANPRSVSSL--SNR------- 228

  Fly  1110 LSAPRKLEYNAGPHILSSPTHHQRQGLPRPLVNSAPNTPTASPNKFHTIPSKIVGTIYESKEEQL 1174
             |:|....|.              |..||.....||:               :.|...||
Frog   229 -SSPVSWRYG--------------QASPRLQAGEAPS---------------LGGCRSES----- 258

  Fly  1175 LPAPPPASGG---SSILPMRPLLRGYN--SHVTLPTRGARGGHHPHQSYLDFCESDIGQGYCSDG 1234
                  ..||   |..:|:|...|..|  .|:.|...|.|               ||..||.||.
Frog   259 ------GVGGWQFSHTMPLRGGTRICNITQHLDLMDPGGR---------------DIKSGYGSDS 302

  Fly  1235 DALRVGSSPGGSRFHDIDNGYLS--EGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPTTIEERI 1297
            | .::|....    :|.|:...|  |.||..:|.|.::|.:|.                  |:..
Frog   303 D-YQLGKETA----NDDDDIITSWDESSSISSGLSDASGNLSS------------------EDCN 344

  Fly  1298 RNSRGSLDSIGTAANGSSAASQAS--------SSGGSTTTHAQNNNNNNNNNSGGGAKMD-GSPH 1353
            ..|..|:.|..||:..|||.:..:        .||.|..:..:...........|..|.: ||..
Frog   345 AVSLASMPSTPTASRRSSAIALRTDSEKRSLVESGLSWHSEPEERGPRRMEYDSGSLKSEHGSSR 409

  Fly  1354 HRPGSRNGRDNWSKMPE---PLN-GQKVEKSDK-----SSP----SRRSMGGGG----------- 1394
            .|   |...|:.|| ||   |:. ||.:.|...     :||    .:.:..|||
Frog   410 WR---REKSDDLSK-PETKKPVTLGQPLRKGKNPPVGVTSPITHTGQIAQKGGGKTEQKATDKTK 470

  Fly  1395 --------SGSSSKQG----SPSSSSRTKGV---PPSFGYVKRANGS--------IASTAEQQNI 1436
                    ..|||..|    ||.:.....|:   ..||||.|.|..|        :....:...|
Frog   471 LTLKTAALQRSSSDAGRDPRSPDAKKPPSGIARPATSFGYKKPATPSSPITGSTTLGKAQKTSGI 535

  Fly  1437 AMMMAAGGAGAN--------GL-------PCGRT-AHVSAVPRTASGR--KVAGGTQTL-----P 1478
            .:....|.||.|        |:       |..|| ....::||.|...  .|.||..|:     .
Frog   536 PVKPTPGPAGINRKTSLDVSGVTEAGFLSPSARTNIQYRSLPRPAKSNTMSVTGGKSTIRPLSST 600

  Fly  1479 NDMNKLP--------PNTQHRSFSLTGPTATQLSQSIRERLATGSHSLPKPGSDLHVFQHRISNR 1535
            .|:|.:|        ||::.:..|..|.....::|:.||:....:.::.:.      .:.|::|.
Frog   601 IDVNLVPVQGKSIGVPNSRLKEPSKVGIVRLGVNQTDREKEKARAKAVAQD------TESRVANA 659

  Fly  1536 GGTR---HDGS--LSDTQTYAEVKPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIGSPALTRHGH 1595
            ....   |.|.  .:.|...|..||       :||...     ||:.:.|....:..|......:
Frog   660 NQIEPQWHKGKEPTAITPHKAITKP-------FLKTPT-----LSNLDKVNSNSLDFPVPEEPLN 712

  Fly  1596 KMIHNRSGGPGQMAGQMSGNESPYVQSPRMNRSNSIRSTKSEKMYP-------SMMSRAGEVEIE 1653
            |.:....|||     .::.:.:|.:   .:|.::..:...|.:|||       ||.|....:.:.
Frog   713 KQLELPQGGP-----CLTPSPAPIL---NINTASFSQGIGSLRMYPKLSGLHRSMESLPLSISVP 769

  Fly  1654 PYYCLPVGTNGVLTAQMAAAMAAQSQAAQGN-------PGVGV-----------------NVGGV 1694
            |  ..|.|....|.......|..:|...:.:       |..|:                 .:||:
Frog   770 P--SPPAGEERNLPNTCWGDMKLKSPVTESSIQDRNTLPKKGLRYQSHSQDESKERRHSHTIGGI 832

  Fly  1695 AWSQPTSPTPLTRGPFN-TAAG----ASVLSPTHGTTSAAGLVGPGGGAG----GGAMVGHRLTY 1750
            ..::..||.|   .|.. |:.|    :|::||:.....|.....|...:.    |.:.:|..|:.
Frog   833 QDAEDLSPLP---PPLPLTSVGKPPISSLVSPSSVPRIARSSSIPAQDSSFELFGSSNLGSSLSL 894

  Fly  1751 PKK--------------NDEVHGSAASLLSGGSSLYGNAEER-QAHEIRRLKRELQDARDQVLSL 1800
            .::              .|:||||..||.|..||.|.:|||: |:.:||:|:|||:.::::|.:|
Frog   895 AERPKGTMTRSGSFRDHTDDVHGSVLSLASSASSTYSSAEEKMQSEQIRKLRRELESSQEKVATL 959

  Fly  1801 SSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQS 1865
            ::|||.||::|.||||||.|||:||..|..||::||.||.|:::||:||:.::.:|
Frog   960 TTQLSANANLVAAFEQSLVNMTSRLRLLADTAQQKDSELVDLKETIDLLKSKNSEA--------- 1015

  Fly  1866 MGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRAIN-ANNGSMPLGMQRQHSTDSMCSLNSI 1929
                       |...||                   |:| .:..|..|.::||:|:||:.|||||
Frog  1016 -----------QAVILG-------------------ALNPTDTASRELRIRRQNSSDSISSLNSI 1050

  Fly  1930 SSGCSAAQDK---NKANKKKGWLRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQ-QELA----SG 1986
            ||.|||...|   :|..|||.||||||.|||:.. |..||:        .::|. :|:|    |.
Frog  1051 SSHCSAGSFKDNDSKKKKKKSWLRSSFNKAFNMK-KGPKTA--------SSYSDIEEMATPDSSA 1106

  Fly  1987 KLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQE--DQHVVEDLKKQ 2049
            .......||          |..||.| |..|||:.:|.       .:|.:.|  ::..|.:|:.:
Frog  1107 PTSPKQQHG----------QAGPPSP-SLHSSPSSSVI-------FEAQEGEEPEKREVSELRSE 1153

  Fly  2050 LREKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQA 2114
            |.||::.|||||||||:||.|||.|:|.|:.|:.|:..||..|:|| |:|...|
Frog  1154 LWEKEMKLTDIRLEALNSAHQLEQLRETMHNMQLEVDLLKAENDRL-KVVPAPS----------- 1206

  Fly  2115 ISPNGSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVA 2179
             :|:|  .|||..|.|.|||.|.:: .:.:||....:|.               |....||
Frog  1207 -APSG--IGSSCPSPRRSLALSLTQ-SLGIPASTDTDLS---------------PMDGLNG---- 1248

  Fly  2180 PLSPSTHVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQE 2244
              |....|.:|     |.......|.|:.
Frog  1249 --SLKREVTVT-----LRTVVRVPPQHII------------------------------------ 1270

  Fly  2245 LDGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPG 2309
                     :.|.:.|             ||.:....|:.|..||::|..|.:||:||:.|:|||
Frog  1271 ---------KGDLKQQ-------------EFFLGSLNINTKADWQSVDNAVCQTFQDYLNRLDPG 1313

  Fly  2310 TNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQG-----VGSLAFDSLIPR 2369
            :.|||..:|::.|.||..||..:...|:..|...:.|....| :.|:|     |..|.|:||||:
Frog  1314 STLGLGKESLSGYSLGHIKRWLDTEVPDTSPSRILKGCTNIL-LHLKGLKERCVDLLVFESLIPK 1377

  Fly  2370 SIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQ 2434
            .::..|:|||.:||||:|.||||||||:||.||||:||.||.|......:..||:..:|.|||:.
Frog  1378 PMLQHYVSLLLKHRRLLLSGPSGTGKSFLAHRLAEYLVERSGREICEGIVTAFNMHQQSCKDLQL 1442

  Fly  2435 YLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTN 2499
            ||.::|.|.....|..|||.||:||::....|:.::.:..|:. ..:|.|.||||.:|....:.|
Frog  1443 YLSNLANQIDRETGSCELPLVIMLDDVSEGGAISELVNGALTC-KYHKCPYIIGTTNQPVKMSPN 1506

  Fly  2500 LQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLE--LQTQHPQPELAAVLAWLPSVWQHINRFL 2562
            ..||.:||.:..:|::||..|||||:|||:|.:.|  :.|.|  .||..||.|:|.:|.|::.||
Frog  1507 HGLHLSFRMLTFSNNVEPANGFLGRYLRRKLLESEGSIGTGH--AELLRVLDWVPRLWYHLHTFL 1569

  Fly  2563 EVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAF 2627
            |.:|:.|..|||..||:||:.::|.:|||.|:||..:.|||.|..::|::::|.: .||.||..:
Frog  1570 EKYSTPDFLIGPCFFLSCPIGIEDFRVWFIDLWNNSIIPYLQEGSKDGIKVHGHK-AAWEDPVEW 1633

  Fly  2628 IRNSYPWPYGPD-----------------SVPPLRQINAEDVGLEGVALTNGDQQDPLLNMLMRL 2675
            :|::.|||....                 |..|.|:.:.:|      :.|...:.|||:.||::|
Frog  1634 VRDTLPWPMAQQDQSKLLHLPQPTVSTHHSTSPPREHSIKD------SPTTSLETDPLMAMLLKL 1692

  Fly  2676 QEAANYSEAQDQESDCASLDSNVT 2699
            |||||:.|:.|:|:.|   ||::|
Frog  1693 QEAANFIESPDRETIC---DSDLT 1713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH	535..637	CDD:214479
		AAA	2382..2531	CDD:214640	67/148 (45%)
		AAA_22	2385..2476	CDD:290137	40/90 (44%)
nav1	XP_002932183.2	Mplasa_alph_rch	<934..>1019	CDD:275316	42/104 (40%)
nav1	XP_002932183.2	AAA	1397..1500	CDD:99707	45/103 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1411
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	689	1.000	Inparanoid score	I682
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001074
OrthoInspector	1	1.000	-	-		otm48342
Panther	1	1.100	-	-	O	PTHR12784
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X908
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150