DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sick and nav3

DIOPT Version :9

Sequence 1:	NP_001260606.1	Gene:	sick / 35277	FlyBaseID:	FBgn0263873	Length:	2707	Species:	Drosophila melanogaster
Sequence 2:	XP_031754793.1	Gene:	nav3 / 100486471	XenbaseID:	XB-GENE-6044394	Length:	2311	Species:	Xenopus tropicalis

Alignment Length:	2635	Identity:	740/2635 - (28%)
Similarity:	1110/2635 - (42%)	Gaps:	770/2635 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 VQYKIRKP----RPLST-----H--SDADSGFLSPCSPEEMRANPAILVLQ-----QCD-----S 529
            |..|:|:|    :|:.|     |  ......:||. |.|..||..:|...|     .||     .
Frog     6 VASKLRQPGVGSKPIHTALPIPHVGRTISQQYLSR-SLELGRAEKSINTCQLPLKSSCDLEDKKR 69

  Fly   530 VQGYM------EIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKPKN 588
            :||.:      :|||||||:||.::..||.:.||..|..||:||||:|:.:.:.|:.|:...||:
Frog    70 LQGSIKETEDSKIYTDWANHYLTKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKIEDINGCPKS 134

  Fly   589 QQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQ------------- 640
            |.||.:||:.||:.|..:.| .::.::..:|..|.|||:|.|||:|||||||
Frog   135 QSQMIENVDVCLNFLAVRGV-NVQGLSAEEIRNGNLKAILGLFFSLSRFKQQQHQQQQYYQSLVE 198

  Fly   641 ------------------------------AKQTKSIGVGCG----GGVGGSSSTLTGSGSVLGI 671
                                          |.|:...|:...    ..:.|.|.......|..|.
Frog   199 LQQHVTHSSSSSETSQPKTLDMQSSLTARYATQSNHSGIATNQKKTTRLPGPSRVPAAGSSTKGQ 263

  Fly   672 GIGGLRTPGSSLNQ-DKNQQEQQQQQQQQQTPQQLAQSL-ENGNEMVNRQIAPAYAKVNG---GT 731
            |...|.....|.|. |||:........::::|:...||. .|||..        |:..:|   .:
Frog   264 GTANLNRRSQSFNSIDKNKPPHYANGNEKESPKGPQQSAGMNGNVQ--------YSTSSGQQVAS 320

  Fly   732 AIPLPATVMVQRRCPPDKVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPPTSNHTIQSLKSGNN 796
            |||.|:.                ..|..:.|:.....:.|...:.:..||.||       .:.::
Frog   321 AIPSPSA----------------SKPWRSKSMNVKHSATSTMLSVKQPSPATS-------PTPSS 362

  Fly   797 NSLRPPSIKSGIPSPSSPQTAPQKHSMLDKLKLFNKEKQQNAVNAASVASKTQIQSKRTSSSSGF 861
            :.|:|| :..|..:.||.|     .|||:|.||    ..:.::.:.| :|...|:...|.|..|
Frog   363 DRLKPP-LSEGSKTSSSAQ-----KSMLEKFKL----NSRGSLRSQS-SSNEVIREDDTLSECG- 415

  Fly   862 SSARSERSDSSLSLNDGHGS-QLKPP---SISVSSQK--PQPKTKQSKLLAAQQKKEQANKATKL 920
                  .:||..|.|....| :|.||   |.::|::|  ||||.|..|    .:.|.::.||.|.
Frog   416 ------ENDSGSSFNSPKVSPKLAPPKAGSKNISNKKCLPQPKDKDDK----NRDKNKSEKAAKE 470

  Fly   921 DKKEKSPARSLNKEESGNESRSSTMGRTGKSSLVRAVGGVEKNTPKTSSKSSLHSKSDSKSSLKA 985
            :|::.|                                   :.:.|:|..:||..|.:..:::|.
Frog   471 EKEQTS-----------------------------------EGSKKSSKIASLIPKGNKTAAVKK 500

  Fly   986 PQLLQSPSSGGLPKPIAAIKGTSKLPSLGGGAGHLPAAESQQN------QQLLKRETSDISSNIS 1044
            ..::  |.|.|:|||.:.:....:..|.|..|    |.|.::|      |..|.::|| .|...:
Frog   501 DSMI--PLSSGIPKPGSKVPAAKQTTSPGSAA----AKEPEKNRTTKGSQTQLTQKTS-ASEKAT 558

  Fly  1045 QPPPAEPPIS----------------TH------------AHIHQNQTPPPPYYANSQPTSHISS 1081
            .|...:.|.|                ||            .|...:.|..||..:.:.||...||
Frog   559 TPLEGKTPSSSAGPGNGTVQLPQQQYTHPNTATVAPFIYRTHTENDSTLVPPADSCTSPTKGESS 623

  Fly  1082 HGFLSEPSTPQHSSGIYGSSRLPPPKSALSAPRKLEYN----AGPHIL----------------- 1125
            :...::....:.|.....:.|:...|:.....:.||..    .|..|.
Frog   624 YSKTAKQCLEELSGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQITHSTLETTFDSTVTTEVS 688

  Fly  1126 -----------SSPTHHQRQGLPRPLVNSAPNT----PTASPNKF-HTIPSKIVGTIYESKEEQL 1174
                       |:.|....|..||.....||:.    |..:|::| ||.||:.:.|
Frog   689 GRNLPSLTSRSSAMTWRLGQASPRLQAGDAPSLVGAYPRNNPSRFIHTDPSRFMYT--------- 744

  Fly  1175 LPAPPPASGGSSILPMRPLLRGYNSHVTLPTRGARGGHHPHQSYLDFC-ESDIGQGYCSDGDALR 1238
               .|....|.|.|       |..|.|.:..:|:..        ||.. |.|:| ||.||||.|
Frog   745 ---TPLRRAGISRL-------GNISQVEISEKGSHD--------LDIASEVDVG-GYMSDGDIL- 789

  Fly  1239 VGSSPGGSRFHDIDNGYLSEGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPTTIEERIRNSRG- 1302
             |.|   .|..||::|||::|...|                  ..|:..::|.....|....||
Frog   790 -GKS---LRSDDINSGYLTDGGLSL------------------YTRSLNRIPDLAASRDVIHRGV 832

  Fly  1303 --------SLDSIGTAANGSS------AASQASSSGGSTTTHAQNNNNNNNNNSGGGAKMDGSPH 1353
                    |.|...:|::|.|      :....::|..|:.|:......||...|...|:......
Frog   833 HDVTVDADSWDDSSSASSGLSDTLDNLSTDDLNTSSISSYTNVAPTRKNNQTQSKTDAEKRSLTD 897

  Fly  1354 HRPGSRNG---RDNWSKMPEPLNGQKVEKSDKSSPSRRSMGGGGS---------GSSS-KQGSPS 1405
            ..|...:.   :|....:|...:|:..|:|||:.....|:...||         |::| :|.|.|
Frog   898 CEPWCNDDIKKQDEDFDIPLDTSGKWKEESDKAGQKSLSVSQTGSWRRGMTAQIGTTSPRQKSGS 962

  Fly  1406 SSSRTKGVPPSFGYVKRANGSIASTAEQQN------------------IAMMMAAGGAGANGLPC 1452
            ||.:|.|........::....:.....|::                  ||...|.|..|..
Frog   963 SSLKTPGKTDDVKASEKVKSPLKGNTLQRSPSDAGKSSGDEGKKPPSGIARPTATGSFGFK---- 1023

  Fly  1453 GRTAHVSAVPRTASGRKVAGGTQTLPNDMNKLPPNT------QHRSFSLTGPTATQLSQSIRERL 1511
             :....|....|.||..:..|:.||    .|:|.::      ..|..||.|      ||:..:.:
Frog  1024 -KAGMASPSMVTGSGATINSGSATL----GKIPKSSCIGGKGAGRKTSLDG------SQNQDDTV 1077

  Fly  1512 ATGS-------HSLPKPGSDLHVFQHRISNRGGTRHDGSLSDTQTYAEVKPEYSSYAMWLKHSNT 1569
            ..|:       .|||:|...   ....|..|||.|...|..|:...::.....|:.   |:..:.
Frog  1078 LLGNSKAALQYRSLPRPSKS---STSGIPGRGGHRSSTSSIDSNVSSKSAGASSTK---LREPSK 1136

  Fly  1570 AGS----------------RLSDGESV--------------------------EQLQIGSPALTR 1592
            .||                ::||.|||                          :...|.||...|
Frog  1137 IGSGGSSPVIINQTDKEKEKVSDSESVSLSSSPKSSPTSVNACGTQGLRQPGSKYPDIASPTFRR 1201

  Fly  1593 -----HGHK----------------------------MIHNRSGGPGQM--AGQMSGNESP---- 1618
                 .|:|                            .:.:.|.|.|.|  ||..||:.||
Frog  1202 LFGSKAGNKPSTTGSTDGGKTTSVMPSPSSTSLARQGSLDSPSSGTGSMGSAGGQSGSSSPLFSK 1266

  Fly  1619 ----------YVQ----SP-------------RMNRSNSIRSTKSEKMYPSMMS-RAGEVEIEPY 1655
                      |.|    ||             ..|.|:|...:|....|.||.| ......|:
Frog  1267 ANELIPDVISYGQSLATSPASVHSFTSGGQVWTANLSSSSAGSKDTPSYQSMTSLHTSSESID-- 1329

  Fly  1656 YCLPVGTNGV---LTAQMAAAMAAQSQAAQGN-------------------PGVGV--------- 1689
              ||:..:|.   |:.|.|.::..::.:.:..                   |..|:
Frog  1330 --LPLSHHGSLSGLSTQEAQSLLMRTGSVRSTLSERGFLYFNSMQLDRNTLPKKGLRYTPSSRQT 1392

  Fly  1690 ------------NVGGVAWSQPTSPTPLTRGPFNTAAG----ASVLSPTHGTTSAAGLVGPG--- 1735
                        :.||:..:...||.....|..::|.|    .:::|||:  .|...:.||.
Frog  1393 SQEEGKEWLRSHSTGGLQDTGSQSPLVSPSGMPSSATGKYHYTNLVSPTN--LSQFSIPGPSMMR 1455

  Fly  1736 ----------------GGAGGGAM--------VGHRLTYPKKNDEVHGSAASLLSGGSSLYGNAE 1776
                            ....|.|:        :.|..::....:|||||:.||:|..||||..||
Frog  1456 SNSIPAQDSSFELYEDSQLCGSAISLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAE 1520

  Fly  1777 ERQAH--EIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGEL 1839
            |: ||  :|::|:|||..::::|.:|:||||.|:|:|.|||:||.|||.||..||.|||:|:.||
Frog  1521 EK-AHSEQIQKLRRELVASQEKVATLTSQLSANSHLVAAFEKSLGNMTGRLQSLTMTAEQKESEL 1584

  Fly  1840 TDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRAIN 1904
            |::::|||:|:.|:..|                |..:||                       |:|
Frog  1585 TELKETIEMLKTQNAAA----------------QAAIQG-----------------------ALN 1610

  Fly  1905 ANNGS-MPLGMQRQHSTDSMCSLNSISSGCS--AAQD-KNKANKKKGWLRSSFTKAFSRNAKISK 1965
            .::.| ..:.::||||::|:.|:||.:|..|  :..| ::|..|||.||||||.:||.:......
Frog  1611 GSDHSHKDMRIRRQHSSESVSSINSATSHSSIGSVNDAESKKKKKKNWLRSSFKQAFGKKKSNKP 1675

  Fly  1966 TSRHVGHHHHHNHSQQELASGKLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAK 2030
            .|.|        ...:||....:|                 .:|.|.::...:.:.::.|..::.
Frog  1676 PSSH--------SDIEELTDSSVP-----------------SSPKLQHNGDDAGSLSLKLSQSST 1715

  Fly  2031 PIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERL 2095
            .|....:.:..::..||.:||||:|.||||||||||||..|:.::|.||:|:.|:..||..|:||
Frog  1716 DICECTEAEAEIILQLKGELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRL 1780

  Fly  2096 QKLVTTRSLAGSEASLGQAISPNGSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLP 2160
            :          :|.|     ||..:|..|||.|   |...|:||..:
Frog  1781 K----------AETS-----SPGKTVRPSSESS---SCTSSSSRQSL------------------ 1809

  Fly  2161 PAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAI 2225
                          |:|:..|:.|.|                     ::|...|.|:.||
Frog  1810 --------------GLSLNNLNVSDH---------------------STADNILDDMRDG----- 1834

  Fly  2226 ACYLGQPEAFAKYCEELQEL----DGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKT 2286
                    ||.|....::.:    .||   |...|::|:.             ::|....:||||
Frog  1835 --------AFQKEGRSVKIVVSINKGF---GRRKDAKSRF-------------YLIGSIGVSGKT 1875

  Fly  2287 TWQNLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTL 2351
            .|..||.|:|:.:|:|:.|:||..||||.:|||:||.:|:..|......||:|||||:||:...:
Frog  1876 KWDVLDAVIRRLYKEYIYRVDPAANLGLTSDSISSYCIGDIVRANNSEVPEMLPCGYLVGANNAI 1940

  Fly  2352 YICLQG-----VGSLAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSA 2411
            .:.|:|     :.|..||:|||:.|..|||:||.||.|:||.|||||||:|||.:|||:::.:|.
Frog  1941 TVNLKGLEENSLDSFVFDTLIPKPITQRYINLLMEHHRIILSGPSGTGKTYLANKLAEYVINKSG 2005

  Fly  2412 RGNPSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLS 2476
            |....||:|||||||||||:|||||.::|:|.:..|.: ::|.|||||||||..:|.|:|:..|:
Frog  2006 RKKIEEAVATFNVDHKSSKELRQYLANLADQCSADNDI-DIPLVIILDNLHHIGSLSDIFNGFLN 2069

  Fly  2477 AGPANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQ 2541
            . ..:|.|.|||||:|:..::.||:|||||||||.:||.:||||||||.|||:|.:.|::.....
Frog  2070 C-KYSKCPYIIGTMNQSISSSPNLELHHNFRWVLCSNHTDPVKGFLGRCLRRKLIETEIEQNMRN 2133

  Fly  2542 PELAAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEA 2606
            .:|..::.|:|..|.|||.|||.||||||||||||||:||||:..|::|:||:|||.:.|||:||
Frog  2134 NDLIKIIEWIPKAWHHINGFLETHSSSDVTIGPRLFLSCPMDVDGSKIWYTDLWNYSVIPYLLEA 2198

  Fly  2607 VREGVQLYGRRGGAWNDPSAFIRNSYPW--PYGPDSVPPLRQINAEDVGLEGVA----------L 2659
            ||||:|:||:| ..|.|||.::..::||  .......|.|.|:..||||.:|.|          :
Frog  2199 VREGLQMYGKR-APWEDPSKWVLETFPWSTSSSQQESPALLQLRPEDVGYDGYATAKEGTTSKNV 2262

  Fly  2660 TNGDQQ-DPLLNMLMRLQEAANYSEAQDQESDCAS 2693
            :..::: |||:|||||||||||:|.||..:||..|
Frog  2263 SQSEKEGDPLMNMLMRLQEAANFSSAQSCDSDSTS 2297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH	535..637	CDD:214479	45/101 (45%)
		AAA	2382..2531	CDD:214640	86/148 (58%)
		AAA_22	2385..2476	CDD:290137	51/90 (57%)
nav3	XP_031754793.1	CH_NAV3	79..183	CDD:409135	46/104 (44%)
		Herpes_BLLF1	<203..613	CDD:282904	107/504 (21%)
		Smc	<1530..>1783	CDD:224117	106/326 (33%)
		P-loop_NTPase	1963..>1993	CDD:422963	19/29 (66%)
		AAA_22	1979..2065	CDD:379165	50/86 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1411
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	689	1.000	Inparanoid score	I682
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001074
OrthoInspector	1	1.000	-	-		otm48342
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3248
SonicParanoid	1	1.000	-	-		X908
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.080