Protein Alignment sick and nav2a

DIOPT Version :9

• Sequence 1: NP_001260606.1
• Gene: sick / 35277
• FlyBaseID: FBgn0263873
• Length: 2707
• Species: Drosophila melanogaster
• Sequence 2: XP_021327534.1
• Gene: nav2a / 100333160
• ZFINID: ZDB-GENE-120502-3
• Length: 2384
• Species: Danio rerio
• Alignment Length: 2698
• Identity: 777/2698 - (28%)
• Similarity: 1131/2698 - (41%)
• Gaps: 824/2698 - (30%)

  Fly   481 VPSRHVQYKIRKPRPLSTHSDADSGFLSPCSPEEMRANPAILVLQQCDSVQGYM----------- 534
            ||:|.|     .|||..:            ||.:..|:   |.||   |..|:|
Zfish    27 VPTRAV-----APRPCYS------------SPPQSSAH---LHLQ---SQSGWMTSKNYHNVDSG 68

  Fly   535 ---EIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKPKNQQQMFDNV 596
               :|||||||:||.::..||.:.||..|..||:||||:|:.:.:.|:.|:...||::.||.:|:
Zfish    69 EDTQIYTDWANHYLAKSGHKRLIKDLQQDVSDGVLLAEIIQVIANEKIEDINGCPKSRSQMIENI 133

  Fly   597 NSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQ---AKQTKS------------ 646
            ::||..|.::.| .::.::..:|..|.|||:|.|||:|||:|||   ::||.:
Zfish   134 DACLSFLAAKGV-NIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQTSRQTHTQHTHSHTPLIQQ 197

  Fly   647 -------IGVGCGGGVGGSSSTLT------GSGSVLGIGIG---GLRTPGSSLNQDKNQQEQQQQ 695
                   |....|   ..|..|.|      ||.|.|...||   ..|.||.:........|...:
Zfish   198 SSAPAQLISTPHG---PHSHKTQTDMQSRDGSQSKLKFSIGQKKSSRLPGPTSRMSTAGSESSPR 259

  Fly   696 QQ------------QQQTPQQLAQSLENGNEMVNRQIAPAYAKVNGGTAIPLPATVMVQRRCPPD 748
            ..            ..:.....||:.|:...:.:..::.|...::..|.....::..:
Zfish   260 GSISSAGNRRSLVFSDKAKPAAAQAKESSESVTDPALSSACTSLSTSTVASSSSSSAI------- 317

  Fly   749 KVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPPTSNHTIQSLKSGNNNSLRPPSIKSGIPSPSS 813
                  |.|| :.|.|...||.:..:||..::..::...:|:              |..:|:.:.
Zfish   318 ------PQPN-SSSKPWRIKSQNSKHTSATSTGLSTKSDLQA--------------KQPVPAEAP 361

  Fly   814 PQTAPQKHSMLDKLKLFNKEKQQNAVNAASVASKTQIQSKRTSSSSGFSSA-----RSERSDSSL 873
            |:..||| |||:||||||.:.          .||:..|::...:.:|...|     |.|...::.
Zfish   362 PKAVPQK-SMLEKLKLFNSKG----------GSKSSTQTEGAVTPTGGKDAALVLERVETGSNTE 415

  Fly   874 SLNDGHGSQLKPP--SISVSSQKPQPKTKQ------SKLLAAQQKKEQANKATKLDKKEKSPARS 930
            .:.:..|: ::|.  ::||::..|:...|.      |:.|.|  ||..|    |..:|||...::
Zfish   416 PIEEMDGN-VRPTNGAVSVTTSSPKIALKGIAQRTFSRALTA--KKASA----KSSEKEKGKDKN 473

  Fly   931 LNKEESGNESRSSTMGRTGKSSLVRAVGGVEKNTPKTSSK-SSLHSKSDSKSSLK--APQLLQSP 992
            .:|..|.:|...........||:|.|....|   |:.:|| :|...|.......|  .|    :|
Zfish   474 ASKRGSPSEKVEEVKEEVVSSSVVTAPSEPE---PRKASKIASFIPKGGKVGGAKKDGP----AP 531

  Fly   993 SSGGLPKP------IAAIKGTSKLPSLGG-----------GAG---HLPAAESQQNQQLLKRE-- 1035
            ...|:|||      ..|:|| |.|| |||           |||   |..:..|..:..|...|
Zfish   532 VQSGIPKPGSKSAGNGAVKG-SALP-LGGKDNERPRSVRLGAGLGLHRDSRHSSSSSSLASTEGK 594

  Fly  1036 -------------TSDISSN---ISQPPPAEPPISTHAHIHQNQTPPPPYYANSQ---------- 1074
                         |...:||   :..|.|.:      .:.|.|.....|:...:|
Zfish   595 GHPMHSAAPVANGTQSTASNTVSVQLPQPQQ------QYNHPNTATVAPFMYRTQNEADGNMGTN 653

  Fly  1075 -----PTSHISSHGFLSEPSTPQHSSGIYGSSRLPPPKSALSAPRKLE----------------- 1117
                 .:|...|....::.||...|.....:.||...|:.....:.||
Zfish   654 LSSGCRSSDSGSFSKTNQSSTEDLSGEDPETRRLRTVKNIADLRQNLEETMSSLRGTQITHSTLE 718

  Fly  1118 --YNAG-------PHILS-----SP---THHQRQGLPRPLVNSAPNTPTASPNKFHTIPSKIVGT 1165
              ::.|       .:|||     ||   .....|..||.....||:                ||.
Zfish   719 TTFDGGVTTEMSSRNILSMASRPSPLSWASRMGQSSPRLQAGDAPS----------------VGN 767

  Fly  1166 IYESKEEQLLPAPPPASGGSSILPMRPLLRGYNSHVTLPTRGARGGHHPHQSYLDFCESDIG--- 1227
            .|:|:...:.|      |....|...||.:      .|..||:           ..|..::|
Zfish   768 GYQSRSGGVAP------GQGRYLYQAPLRK------QLAARGS-----------GLCGLELGDRV 809

  Fly  1228 ------------QGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGLNGPSSSAGGISPGKHFL 1280
                        .||.||||.|     ...:|..::.:||:::|  ||:..:.....:..|   :
Zfish   810 EDLELAGVGLEMSGYMSDGDVL-----SKNARTDELSSGYMTDG--GLSLYTRRLNRLPDG---M 864

  Fly  1281 SMMRARTQLPTTIEERIRN---SRGSLDSIGTAANGSSAASQASSSGGSTTTHAQNNNNNNNNNS 1342
            :|:|...|         ||   |:|..||...:::.||..|.|..:....|:.:.::..|....|
Zfish   865 AMVRENLQ---------RNASTSQGDADSWDDSSSVSSGISDAIDTDDINTSSSISSYANTPAAS 920

  Fly  1343 GGGAKMDGSPH-----HRPGSRN-------------GRD---------NWSKMPEPLNGQKVEKS 1380
            ..|  ::|.|.     |....||             |.|         .|.:.|..::    |:|
Zfish   921 RKG--LNGQPQTDAEKHSAAERNTSRSIDEVKKSDGGLDCSIKSDSGLKWRRNPSDVS----EES 979

  Fly  1381 DKSSPSRR----------------------------SMGGG-------GSGSS-----SKQG--S 1403
            ||||..|:                            |:..|       |:|.:     |::|  |
Zfish   980 DKSSSGRKTAPVTQTGSWRRGMSAQVGVTVPRTKSTSVSSGSSIIKTQGTGKTDDAKVSEKGCMS 1044

  Fly  1404 PSS---------SSRTKG----------VPPS-FGYVKRANG-----SIASTAEQQNIAMMMAAG 1443
            |||         :.|:.|          ||.| ||: |:.||     ::.:||   :|.::.|:|
Zfish  1045 PSSNILQHSSSDTGRSSGDEAKKTTAGRVPTSTFGF-KKPNGVHNPSNVITTA---SITLVTASG 1105

  Fly  1444 GAGANGLPCGRTAHVSAVPRTA-----SGRKVAGGTQTL--PNDMNKLPPNT----QHRSF---S 1494
            ....:|     :|.:..:|:::     |...:.|....|  |.:...|.|:.    |:||.   |
Zfish  1106 ATITSG-----SATLGKIPKSSALLVGSRGSLKGAVDGLLPPQEDGYLSPSARSTLQYRSLPRPS 1165

  Fly  1495 LTGPTA----TQLSQSIRERLATGSHSL----------PKPGSDLHVFQ-HRISNRGGTRHD--- 1541
            .:|..|    ...:.||...|.|.:..|          |.|.::.|..| ::.....|...|
Zfish  1166 RSGAAARNGNRSSTSSIESSLLTRAPLLTAITANKPRDPGPKTNGHAIQANQTDKEKGVASDIDS 1230

  Fly  1542 ----------GSLSDTQT------YAEVKPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIGSPAL 1590
                      |:.:..||      |:||             |:....||..|::.:|    :|..
Zfish  1231 TRTNPIVSGGGAATIPQTARQGNKYSEV-------------SSPTLRRLFGGKAAKQ----APVT 1278

  Fly  1591 TRHGHK--MI---------HNRSGG-----PGQMAGQMSGNESPYV--------QSPRMNRSNSI 1631
            |....|  |:         |.:|.|     |..:.|  ||..||..        .|.:.:...|:
Zfish  1279 TAESMKNSMVISNPHATLGHTQSSGGPLDSPSTVPG--SGGSSPLYGGRGASIGGSEQASSPGSV 1341

  Fly  1632 RST-----------KSEKMYPSMMSR------------AGEVEIEPYYCLPVGTNGVLTAQMAAA 1673
            .||           .|...|||:.|.            :|....:.:..| :.|....|....:.
Zfish  1342 YSTGTGTWGTTISSSSALGYPSVSSMHTSSESIDMSVGSGHPRDDVHPAL-MRTGSAKTGMSESP 1405

  Fly  1674 MAAQSQAAQGNPGV------------------------GVNVGGVAWSQPTSPTPLTRGPFNTAA 1714
            :::.|.:.:.|...                        ..:.||:..|...|       ||:|
Zfish  1406 LSSPSNSPKFNRNTLPRKQDRYAPSQQLRQEEARDWLRSHSAGGLQDSASNS-------PFST-- 1461

  Fly  1715 GASVLSPTHGTTSAAGLVGPGGGA--GGGAMVGHRLT---------------------------- 1749
            |:|:.||:....:.|.|..|..||  ...::..:.||
Zfish  1462 GSSLTSPSGTRFNFAQLGSPTTGAQINLASLRNNSLTSQDNPLDSHADSRLRNSCMSLDEKTRTM 1526

  Fly  1750 -----YPKKNDEVHGSAASLLSGGSSLYGNAEERQAHEIRRLKRELQDARDQVLSLSSQLSTNAH 1809
                 :....:|||||:.||:|..||:|...||:...|||:|:|||..::::|.:|::|||.|||
Zfish  1527 SRSGSFRDGFEEVHGSSLSLVSSTSSVYSTTEEKSQSEIRKLRRELDASQEKVSALTTQLSANAH 1591

  Fly  1810 VVTAFEQSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQG 1874
            :|.||||||.|||.||..||.|||:||.||.::|:|||||:||:..|                |.
Zfish  1592 LVAAFEQSLGNMTIRLKSLTMTAEQKDSELNELRKTIELLKKQNAVA----------------QA 1640

  Fly  1875 QVQGQALGQALGQPGSDQKPPNSGSQRAINANNGS-----MPLGMQRQHSTDSMCSLNSISSGCS 1934
            .:.|     .:..|....|...:|       ||||     ..|.|:||||:||:.|:.|.:|..|
Zfish  1641 AING-----VINTPELTCKSERTG-------NNGSGLGAPPDLRMRRQHSSDSVSSITSATSHSS 1693

  Fly  1935 AAQ-----DKNKANKKKGW-------------------LRSSFTKAFSRNAKISKTSRHVGHHHH 1975
            ...     |.:...|||.|                   |||||.:|||:.......|.|......
Zfish  1694 LGSNMDNPDSSSKKKKKNWLVTCAGGVESDDECEYVYELRSSFKQAFSKKKSPKSASSHSDIEEM 1758

  Fly  1976 HNHSQQELASGKLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQEDQ 2040
            .:.|..  :|.||| |||.|....|..          |:..||...           |.:|.|.:
Zfish  1759 TDSSLP--SSPKLP-HNGSGSTALLRR----------NTHSSSILS-----------DCLDGEAE 1799

  Fly  2041 HVVEDLKKQLREKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLA 2105
            .|:: |:.:||||::.||||||||||||.||:.|:|.||:|:.|:..||..|:||:        .
Zfish  1800 TVMQ-LRNELREKEMKLTDIRLEALSSAHQLDQLREAMNRMQGEIEKLKSENDRLK--------V 1855

  Fly  2106 GSEASLGQAISPNGSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPP 2170
            .|.||        ||.| ||:|| .|:                              |.|...|.
Zfish  1856 ESHAS--------GSRA-SSQVS-VYN------------------------------PTPTPTPG 1880

  Fly  2171 PAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAF 2235
            .:.:.::   |:.||..|:.......:.:......|:              ||.::
Zfish  1881 LSQHSLN---LTESTSFDMLLDDSGGDGSSRKESRHV--------------KIVVS--------- 1919

  Fly  2236 AKYCEELQELDGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFK 2300
                  |||           |...:.:.::.:       |:|.|..:||||.|..||.|||:.||
Zfish  1920 ------LQE-----------DVMWKEDCRTRH-------FLIGCIGVSGKTKWDVLDGVVRRLFK 1960

  Fly  2301 DYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQGVG-----S 2360
            :|:..:||.::|||.:||:..|.:|:..|......||||||||:||...|:.|.|:||.     |
Zfish  1961 EYIRHVDPVSHLGLGSDSVEGYRIGDVVRCSGANTPELLPCGYLVGENDTINISLKGVNSQSQDS 2025

  Fly  2361 LAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVD 2425
            |.|::|||:.::.||:|||.||||:||.|||||||||||.||||.|..:..:......|.|||||
Zfish  2026 LVFETLIPKPMLQRYVSLLQEHRRIILSGPSGTGKSYLAHRLAEHLALQEGKLPSDSNIVTFNVD 2090

  Fly  2426 HKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTM 2490
            |||||:|||||.:|.||.:.|...:|.|.|:|||||||.|:||::||.||:. ...:.|.|||||
Zfish  2091 HKSSKELRQYLANIVEQCSAAGQDTEAPLVLILDNLHHISSLGEIFSGLLNC-RYQRCPYIIGTM 2154

  Fly  2491 SQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVW 2555
            ||||.:..||||||||||||.|||||||||||||:|||:|.:.|:..:...|||..::.|:|.||
Zfish  2155 SQATSSAPNLQLHHNFRWVLCANHMEPVKGFLGRYLRRKLIETEIGNRTRNPELVKIIDWIPQVW 2219

  Fly  2556 QHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGA 2620
            ||:|||||.||||||||||||||:||||:..|:|||||:|||.:.||::||||||:|||||| .|
Zfish  2220 QHLNRFLEAHSSSDVTIGPRLFLSCPMDVDGSRVWFTDLWNYSIIPYMLEAVREGLQLYGRR-AA 2283

  Fly  2621 WNDPSAFIRNSYPWPYG---PDSVPPLRQINAEDVGLEGVAL---------TNGDQQ-DPLLNML 2672
            |.||:.::..::||...   || .|.|.|:..||||.:|.:.         |..|.. |||:|||
Zfish  2284 WEDPALWVLETFPWAASHQHPD-WPALLQLRPEDVGFDGYSASREGVSKQSTQSDSDADPLMNML 2347

  Fly  2673 MRLQEAANYSEAQDQESDCAS-------LDSNV 2698
            :||:|||:.|..|..:||..|       |||::
Zfish  2348 LRLKEAASCSSPQSYDSDSNSNSHHDDILDSSL 2380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH	535..637	CDD:214479	43/101 (43%)
		AAA	2382..2531	CDD:214640	96/148 (65%)
		AAA_22	2385..2476	CDD:290137	54/90 (60%)
nav2a	XP_021327534.1	CH	72..175	CDD:237981	44/103 (43%)
		Herpes_BLLF1	<1068..1341	CDD:330317	64/300 (21%)
		SMC_N	<1559..>1635	CDD:330553	44/75 (59%)
		PRKG1_interact	1804..1859	CDD:318172	31/62 (50%)
		AAA_22	2045..>2130	CDD:315964	52/84 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	368	1.000	Domainoid score	I867
eggNOG	1	0.900	-	-		E1_2CMAI
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	780	1.000	Inparanoid score	I507
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001074
OrthoInspector	1	1.000	-	-		otm24695
orthoMCL	1	0.900	-	-		OOG6_103597
Panther	1	1.100	-	-	O	PTHR12784
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X908
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950