DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and nav2a

DIOPT Version :10

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:XP_021333401.2 Gene:nav2a / 100333160 ZFINID:ZDB-GENE-120502-3 Length:2372 Species:Danio rerio


Alignment Length:2647 Identity:770/2647 - (29%)
Similarity:1125/2647 - (42%) Gaps:781/2647 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   502 ADSGFLSPCSPEEMRANPAILVLQQCDSVQGYMEIYTDWANYYLERAKSKRKVTDLSADCRDGLL 566
            ::||..:..|..:.| .|.|      ..::...:|||||||:||.::..||.:.||..|..||:|
Zfish    53 SESGAEASASQPQKR-KPVI------HGLEDQKKIYTDWANHYLAKSGHKRLIKDLQQDVSDGVL 110

  Fly   567 LAEVIEAVTSFKVPDLVKKPKNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALF 631
            |||:|:.:.:.|:.|:...||::.||.:|:::||..|.::.| .::.::..:|..|.|||:|.||
Zfish   111 LAEIIQVIANEKIEDINGCPKSRSQMIENIDACLSFLAAKGV-NIQGLSAEEIRNGNLKAILGLF 174

  Fly   632 FALSRFKQQ---AKQTKS-------------------IGVGCGGGVGGSSSTLT------GSGSV 668
            |:|||:|||   ::||.:                   |....|   ..|..|.|      ||.|.
Zfish   175 FSLSRYKQQQQTSRQTHTQHTHSHTPLIQQSSAPAQLISTPHG---PHSHKTQTDMQSRDGSQSK 236

  Fly   669 LGIGIG---GLRTPGSSLNQDKNQQEQQQQQQ------------QQQTPQQLAQSLENGNEMVNR 718
            |...||   ..|.||.:........|...:..            ..:.....||:.|:...:.:.
Zfish   237 LKFSIGQKKSSRLPGPTSRMSTAGSESSPRGSISSAGNRRSLVFSDKAKPAAAQAKESSESVTDP 301

  Fly   719 QIAPAYAKVNGGTAIPLPATVMVQRRCPPDKVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPPT 783
            .::.|...::..|.....::..:             |.|| :.|.|...||.:..:||..::..:
Zfish   302 ALSSACTSLSTSTVASSSSSSAI-------------PQPN-SSSKPWRIKSQNSKHTSATSTGLS 352

  Fly   784 SNHTIQSLKSGNNNSLRPPSIKSGIPSPSSPQTAPQKHSMLDKLKLFNKEKQQNAVNAASVASKT 848
            :...:|:              |..:|:.:.|:..||| |||:||||||.:.          .||:
Zfish   353 TKSDLQA--------------KQPVPAEAPPKAVPQK-SMLEKLKLFNSKG----------GSKS 392

  Fly   849 QIQSKRTSSSSGFSSA-----RSERSDSSLSLNDGHGSQLKPP--SISVSSQKPQPKTKQ----- 901
            ..|::...:.:|...|     |.|...::..:.:..|: ::|.  ::||::..|:...|.     
Zfish   393 STQTEGAVTPTGGKDAALVLERVETGSNTEPIEEMDGN-VRPTNGAVSVTTSSPKIALKGIAQRT 456

  Fly   902 -SKLLAAQQKKEQANKATKLDKKEKSPARSLNKEESGNESRSSTMGRTGKSSLVRAVGGVEKNTP 965
             |:.|.|  ||..|    |..:|||...::.:|..|.:|...........||:|.|....|   |
Zfish   457 FSRALTA--KKASA----KSSEKEKGKDKNASKRGSPSEKVEEVKEEVVSSSVVTAPSEPE---P 512

  Fly   966 KTSSK-SSLHSKSDSKSSLK--APQLLQSPSSGGLPKP------IAAIKGTSKLPSLGG------ 1015
            :.:|| :|...|.......|  .|    :|...|:|||      ..|:|| |.|| |||      
Zfish   513 RKASKIASFIPKGGKVGGAKKDGP----APVQSGIPKPGSKSAGNGAVKG-SALP-LGGKDNERP 571

  Fly  1016 -----GAG---HLPAAESQQNQQLLKRE---------------TSDISSN---ISQPPPAEPPIS 1054
                 |||   |..:..|..:..|...|               |...:||   :..|.|.:    
Zfish   572 RSVRLGAGLGLHRDSRHSSSSSSLASTEGKGHPMHSAAPVANGTQSTASNTVSVQLPQPQQ---- 632

  Fly  1055 THAHIHQNQTPPPPYYANSQ---------------PTSHISSHGFLSEPSTPQHSSGIYGSSRLP 1104
              .:.|.|.....|:...:|               .:|...|....::.||...|.....:.||.
Zfish   633 --QYNHPNTATVAPFMYRTQNEADGNMGTNLSSGCRSSDSGSFSKTNQSSTEDLSGEDPETRRLR 695

  Fly  1105 PPKSALSAPRKLE-------------------YNAG-------PHILS-----SP---THHQRQG 1135
            ..|:.....:.||                   ::.|       .:|||     ||   .....|.
Zfish   696 TVKNIADLRQNLEETMSSLRGTQITHSTLETTFDGGVTTEMSSRNILSMASRPSPLSWASRMGQS 760

  Fly  1136 LPRPLVNSAPNTPTASPNKFHTIPSKIVGTIYESKEEQLLPAPPPASGGSSILPMRPLLRGYNSH 1200
            .||.....||:                ||..|:|:...:.|      |....|...||.:     
Zfish   761 SPRLQAGDAPS----------------VGNGYQSRSGGVAP------GQGRYLYQAPLRK----- 798

  Fly  1201 VTLPTRGARGGHHPHQSYLDFCESDIG---------------QGYCSDGDALRVGSSPGGSRFHD 1250
             .|..||:           ..|..::|               .||.||||.|     ...:|..:
Zfish   799 -QLAARGS-----------GLCGLELGDRVEDLELAGVGLEMSGYMSDGDVL-----SKNARTDE 846

  Fly  1251 IDNGYLSEGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPTTIEERIRN---SRGSLDSIGTAAN 1312
            :.:||:::|  ||:..:.....:..|   ::|:|...|         ||   |:|..||...:::
Zfish   847 LSSGYMTDG--GLSLYTRRLNRLPDG---MAMVRENLQ---------RNASTSQGDADSWDDSSS 897

  Fly  1313 GSSAASQASSSGGSTTTHAQNNNNNNNNNSGGGAKMDGSPH-----HRPGSRN------------ 1360
            .||..|.|..:....|:.:.::..|....|..|  ::|.|.     |....||            
Zfish   898 VSSGISDAIDTDDINTSSSISSYANTPAASRKG--LNGQPQTDAEKHSAAERNTSRSIDEVKKSD 960

  Fly  1361 -GRD---------NWSKMPEPLNGQKVEKSDKSSPSRR--------------------------- 1388
             |.|         .|.:.|..:    :|:|||||..|:                           
Zfish   961 GGLDCSIKSDSGLKWRRNPSDV----LEESDKSSSGRKTAPVTQTGSWRRGMSAQVGVTVPRTKS 1021

  Fly  1389 -SMGGG-------GSGSS-----SKQG--SPSS---------SSRTKG----------VPPS-FG 1418
             |:..|       |:|.:     |::|  ||||         :.|:.|          ||.| ||
Zfish  1022 TSVSSGSSIIKTQGTGKTDDAKVSEKGRMSPSSNILQHSSSDTGRSSGDEAKKTTAGRVPTSTFG 1086

  Fly  1419 YVKRANG-----SIASTAEQQNIAMMMAAGGAGANGLPCGRTAHVSAVPRTASGRKVAGGTQTL- 1477
            : |:.||     ::.:||   :|.::.|:|....:|     :|.:..:|:  |...:.||..:| 
Zfish  1087 F-KKPNGVHNPSNVITTA---SITLVTASGAIITSG-----SATLGKIPK--SSALLVGGRGSLK 1140

  Fly  1478 --------PNDMNKLPPNT----QHRSF---SLTGPTA----TQLSQSIRERLATGSHSL----- 1518
                    |.:...|.|:.    |:||.   |.:|..|    ...:.||...|.|.:..|     
Zfish  1141 GAVDGLLPPQEDGYLSPSARSTLQYRSLPRPSRSGAAARNGNRSSTSSIESSLLTRAPLLTAITA 1205

  Fly  1519 -----PKPGSDLHVFQ-HRISNRGGTRHD-------------GSLSDTQT------YAEVKPEYS 1558
                 |.|.::.|..| ::.....|...|             |:.:..||      |:||     
Zfish  1206 NKPRDPGPKTNGHAIQANQTDKEKGVASDIDSTRTNPIVSGGGAATIPQTARQGNKYSEV----- 1265

  Fly  1559 SYAMWLKHSNTAGSRLSDGESVEQLQIGSPALTRHGHK-----------MIHNRSGG-----PGQ 1607
                    |:....||..|::.:|    :|..|....|           :.|.:|.|     |..
Zfish  1266 --------SSPTLRRLFGGKAAKQ----APVTTAESMKNSVVISNPHATLGHTQSSGGPLDSPST 1318

  Fly  1608 MAGQMSGNESPYV--------QSPRMNRSNSIRST-----------KSEKMYPSMMS-RAGEVEI 1652
            :.|  ||..||..        .|.:.:...|:.||           .|...|||:.| ......|
Zfish  1319 VPG--SGGSSPLYGGRGASIGGSEQASSPGSVYSTGTGTWGTTISSSSALGYPSVSSMHTSSESI 1381

  Fly  1653 EPYYCLPVGT----NGVLTAQM--AAAMAAQSQAAQGNPGVGVNVGGVAWSQPT--------SPT 1703
            :    :.||:    :.|..|.|  .:|....|::...:|.     ....:::.|        :|:
Zfish  1382 D----MSVGSGHPRDDVHPALMRTGSAKTGMSESPLSSPS-----NSPKFNRNTLPRKQDRYAPS 1437

  Fly  1704 PLTR----------------------GPFNTAAGASVLSPTHGTTSAAGLVGPGGGA--GGGAMV 1744
            |..|                      .||:|  |:|:.||:....:.|.|..|..||  ...::.
Zfish  1438 PQLRQEEARDWLRSHSAGGLQDSASNSPFST--GSSLTSPSGTRFNFAQLGSPTTGAQINLASLR 1500

  Fly  1745 GHRLT---------------------------------YPKKNDEVHGSAASLLSGGSSLYGNAE 1776
            .:.||                                 :....:|||||:.||:|..||:|...|
Zfish  1501 NNSLTSQDNPLDSHADSRLRNSCMSLDEKTRTMSRSGSFRDGFEEVHGSSLSLVSSTSSVYSTTE 1565

  Fly  1777 ERQAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGELTD 1841
            |:...|||:|:|||..::::|.:|::|||.|||:|.||||||.|||.||..||.|||:||.||.:
Zfish  1566 EKSQSEIRKLRRELDASQEKVSALTTQLSANAHLVAAFEQSLGNMTIRLKSLTMTAEQKDSELNE 1630

  Fly  1842 MRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRAINAN 1906
            :|:|||||:||:..|                |..:.|     .:..|....|...:|       |
Zfish  1631 LRKTIELLKKQNAVA----------------QAAING-----VINTPELTCKSERTG-------N 1667

  Fly  1907 NGS-----MPLGMQRQHSTDSMCSLNSISSGCSAAQ-----DKNKANKKKGWLRSSFTKAFSRNA 1961
            |||     ..|.|:||||:||:.|:.|.:|..|...     |.:...|||.||||||.:|||:..
Zfish  1668 NGSGLGAPPDLRMRRQHSSDSVSSITSATSHSSLGSNMDNPDSSSKKKKKNWLRSSFKQAFSKKK 1732

  Fly  1962 KISKTSRHVGHHHHHNHSQQELASGKLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLI 2026
            .....|.|.......:.|..  :|.||| |||.|....|..          |:..||...     
Zfish  1733 SPKSASSHSDIEEMTDSSLP--SSPKLP-HNGSGSTALLRR----------NTHSSSILS----- 1779

  Fly  2027 DNAKPIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHN 2091
                  |.:|.|.:.|:: |:.:||||::.||||||||||||.||:.|:|.||:|:.|:..||..
Zfish  1780 ------DCLDGEAETVMQ-LRNELREKEMKLTDIRLEALSSAHQLDQLREAMNRMQGEIEKLKSE 1837

  Fly  2092 NERLQKLVTTRSLAGSEASLGQAISPNGSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEE 2156
            |:||:        ..|.||        ||.| ||:|| .|:                        
Zfish  1838 NDRLK--------VESHAS--------GSRA-SSQVS-VYN------------------------ 1860

  Fly  2157 DCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPVHMASATEELADVCDGK 2221
                  |.|...|..:.:.::   |:.||..|:.......:.:......|:              
Zfish  1861 ------PTPTPTPGLSQHSLN---LTESTSFDMLLDDSGGDGSSRKESRHV-------------- 1902

  Fly  2222 KIAIACYLGQPEAFAKYCEELQELDGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKT 2286
            ||.::               |||           |...:.:.::.:       |:|.|..:||||
Zfish  1903 KIVVS---------------LQE-----------DVMWKEDCRTRH-------FLIGCIGVSGKT 1934

  Fly  2287 TWQNLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTL 2351
            .|..||.|||:.||:|:..:||.::|||.:||:..|.:|:..|......||||||||:||...|:
Zfish  1935 KWDVLDGVVRRLFKEYIRHVDPVSHLGLGSDSVEGYRIGDVVRCSGANTPELLPCGYLVGENDTI 1999

  Fly  2352 YICLQGVG-----SLAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSA 2411
            .|.|:||.     ||.|::|||:.::.||:|||.||||:||.|||||||||||.||||.|..:..
Zfish  2000 NISLKGVNSQSQDSLVFETLIPKPMLQRYVSLLQEHRRIILSGPSGTGKSYLAHRLAEHLALQEG 2064

  Fly  2412 RGNPSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLS 2476
            :......|.||||||||||:|||||.:|.||.:.|...:|.|.|:|||||||.|:||::||.||:
Zfish  2065 KLPSDSNIVTFNVDHKSSKELRQYLANIVEQCSAAGQDTEAPLVLILDNLHHISSLGEIFSGLLN 2129

  Fly  2477 AGPANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQ 2541
            . ...:.|.|||||||||.:..||||||||||||.|||||||||||||:|||:|.:.|:..:...
Zfish  2130 C-RYQRCPYIIGTMSQATSSAPNLQLHHNFRWVLCANHMEPVKGFLGRYLRRKLIETEIGNRTRN 2193

  Fly  2542 PELAAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEA 2606
            |||..::.|:|.||||:|||||.||||||||||||||:||||:..|:|||||:|||.:.||::||
Zfish  2194 PELVKIIDWIPQVWQHLNRFLEAHSSSDVTIGPRLFLSCPMDVDGSRVWFTDLWNYSIIPYMLEA 2258

  Fly  2607 VREGVQLYGRRGGAWNDPSAFIRNSYPWPYG---PDSVPPLRQINAEDVGLEGVAL--------- 2659
            ||||:|||||| .||.||:.::..::||...   || .|.|.|:..||||.:|.:.         
Zfish  2259 VREGLQLYGRR-AAWEDPALWVLETFPWAASHQHPD-WPALLQLRPEDVGFDGYSASREGVSKQS 2321

  Fly  2660 TNGDQQ-DPLLNMLMRLQEAANYSEAQDQESDCAS-------LDSNV 2698
            |..|.. |||:|||:||:|||:.|..|..:||..|       |||::
Zfish  2322 TQSDSDADPLMNMLLRLKEAASCSSPQSYDSDSNSNSHHDDILDSSL 2368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH_NAV2-like 535..638 CDD:409061 44/102 (43%)
PHA03247 <729..1182 CDD:223021 120/555 (22%)
Atrophin-1 <985..>1182 CDD:460830 57/283 (20%)
McrB <2368..2597 CDD:441011 144/228 (63%)
nav2aXP_021333401.2 None

Return to query results.
Submit another query.