DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and nav1b

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:XP_017212240.1 Gene:nav1b / 100005000 ZFINID:ZDB-GENE-120215-84 Length:1825 Species:Danio rerio


Alignment Length:2122 Identity:548/2122 - (25%)
Similarity:849/2122 - (40%) Gaps:547/2122 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   806 SGIPSPSSPQTAPQKHSMLDKLKLFNKEKQQNAVNAASVASKTQIQSKRTSSSSGFSSARSERSD 870
            ||||.|.|                |:| ....:.:||.:....|.:|.|:||:|..||.      
Zfish     8 SGIPLPRS----------------FSK-GDSRSFSAAFLTPAGQNKSGRSSSTSSVSSL------ 49

  Fly   871 SSLSLNDGHGSQLKPPSISVSSQKPQPKTKQSKLLAAQQKKEQANKATKLDKKEKSPARSLNKEE 935
             |:|.....|:.|:.|                   .||......|.:..:.|:|..|      ::
Zfish    50 -SVSKEFLKGTSLRGP-------------------RAQFIPAATNSSPNVPKREVIP------QK 88

  Fly   936 SGNESRSSTMGRTGKSSLVRAVGGVEKNTPKTSSKSSLHSKS-DSKSSLKAPQLLQSPSSGGLPK 999
            |....|..::.:.|...:       ||:|.:.......|.:| |::|..::.|  :.||:|.:..
Zfish    89 SPQGLRRGSLPQDGFRDM-------EKHTNRNWRTGHQHFRSLDNESESESGQ--RRPSNGNMLW 144

  Fly  1000 PIAAIKGTSKLPSLGGGAGHLPAAESQQNQQLLKR------ETSDISSNISQPPP---AEPPIST 1055
            ..:|                  |.:....:|..||      ||..::.|..:..|   |.|||..
Zfish   145 ETSA------------------AVQRDAQKQRTKRMAYPDGETKSLARNTGRESPRMAAVPPIRF 191

  Fly  1056 HAHIHQNQTPPPPYYANSQPTSHISSHGFLS-------EPSTPQHSSGIYGSSRLPPPKSALSAP 1113
            ...:.::      ..|:.:..|     |:.|       |...|:       |.|....::.|...
Zfish   192 RLQVRED------VEASLEDLS-----GYTSDWMEVCWEDLDPE-------SQRKRTVQNVLDLR 238

  Fly  1114 RKLEYNAGPHILSS--PTHHQRQGLPRPLVNSAPNTPTASPNKFHTIPSKIVGTIYESKEEQLLP 1176
            :.||     ..:||  .|...:..|...:...:..|...|.:......|.: ...:.....:|..
Zfish   239 QNLE-----ETMSSLRGTQLSQSCLESSVCYDSDETNARSISSLSNRSSPL-SWRHGQSSPRLQA 297

  Fly  1177 APPPASGGSSILPMRPLLRGYNSHVTLPTR-GARGGHHPHQSYLDFCESDIGQGYCSDGDALRVG 1240
            ...|:|.|||.|......: |.|. |:|.| .:|..|.....:||..:||:..||.||.|.|   
Zfish   298 GDAPSSTGSSYLSGTKASQ-YTSQ-TMPARCSSRLSHTSRSEFLDAGDSDLKSGYLSDSDVL--- 357

  Fly  1241 SSPGGSRFHDIDNGYLSEGSSGLNGPSSSAGGISPGKHFLS-----MMRARTQLPTTIEERIRNS 1300
                ....:|.|:.  ...::|.:..||.:.|:|.|...||     ...:...||||.....|||
Zfish   358 ----CKSLNDEDDD--DNLANGWDESSSISSGLSDGSDNLSSEDLNASSSLNSLPTTPVGSRRNS 416

  Fly  1301 ---------RGSLDSIGTAANGSSAASQASSSG----GSTTTHAQNNNNNNNNNSGGGA-KMDGS 1351
                     :.||...|.|.....:.....:.|    ||..:.............|... ||:..
Zfish   417 SVMLRTDAEKRSLVESGLAWYSEDSKCLRKTDGVYDTGSLKSEPSCKWRKTRLPDGPAMDKMNKG 481

  Fly  1352 PHHRPGSRNGRDNWSKMPEPLNG-------------------------QKVEKSDKSSPSRRSMG 1391
            ...:|.|.....::.|...|..|                         .||:.|.|::..:||..
Zfish   482 ELKKPQSLGQTSSFRKSRNPPVGVTSPITHTSQSVLKVAVCKGDPKAVDKVKMSVKATGLQRSRS 546

  Fly  1392 GGGSGSSSKQGSPSSSSRTKGVPPSFGYVK------------------RANGSIASTAEQQNIAM 1438
            ..|..:..::  |.|.........||||.|                  ..:.::..|.:...|.:
Zfish   547 DAGRDNEHRK--PPSGLMKPSAGSSFGYKKPLTTGTATVLTPGGATITSGSATVGKTPKSSGIPI 609

  Fly  1439 M-MAAGGAGANGL-----------PCGR-TAHVSAVPRTA-------SGRKVAGGTQTLPNDMNK 1483
            . :..|||..|.|           |..| :....::||.|       :||.::|...:....:..
Zfish   610 KPVPGGGARKNSLDASGSEQGFLAPNARGSIQYRSLPRPAKNSAMSLTGRPISGNIDSSLLSLKP 674

  Fly  1484 LP--PNTQ-------------HRSFSLTGPTATQLSQSIRERLATGSHSLPKPGSDLHVF----- 1528
            :|  |||.             .|: |.|||    ::|:.||:    .....|..:||.:.     
Zfish   675 VPALPNTMPSRGKDGGSLKAASRT-SSTGP----VNQTDREK----EKERAKAKADLEISCLKAE 730

  Fly  1529 ------------QHRISNRGGTRHDGSLSDTQTYAEVKPEYSSYAMWLKHSNTAGSRLSDG-ESV 1580
                        .||:.....:::....|.|.|...:..:..::...|.|.:...|...|. ..:
Zfish   731 SQADGCGETLEKIHRVRRTSSSKYPELSSPTSTPRLLSSKSLAHPPSLAHLDKLNSNSLDSCIPI 795

  Fly  1581 EQLQIGSPALTRHGHKMIHNRSGGPGQMAGQMSGNESP--YVQSPRMNRSNSIRSTKSEKMYPSM 1643
            ..|....|..::     :.:.:|  |::|.::|.:.:|  ::.||......::..:.|..:||.|
Zfish   796 HDLPPKIPPFSK-----LQDLAG--GRVAPRLSPSPAPVLHIDSPSCFSGQALSVSSSPILYPKM 853

  Fly  1644 MSRAGEVEIEPYYCLPVGTNGVLTAQMAAAMAAQSQAAQGNPGVGVNVGGVAWSQPTSPTPLTRG 1708
            ......:|..|.:                 |:..::|..|....|.:.|  .|. .:|.|.:|.|
Zfish   854 SGLHRSMESLPLH-----------------MSLPAKADLGEREEGRSTG--TWG-ASSRTSVTLG 898

  Fly  1709 P-----------------------FNTAAGASVLSPTHGTTSAAGLVGP----------GGGAG- 1739
            .                       .::|....:.||||.|.:..|...|          |.|:| 
Zfish   899 DRYSSGHSEGEGRERRHSHTITSMTDSATPPQLPSPTHTTPAYIGKTPPTSVVTPIPNSGSGSGI 963

  Fly  1740 ----------------GGAMVGHRLTY---PKK----------NDEVHGSAASLLSGGSSLYGNA 1775
                            |.:.:|..|:.   ||.          .::||||..||.|..||.|.|.
Zfish   964 TRSSSIPASDLGYDLYGTSPLGSSLSLADRPKSMMRSGSFREPAEDVHGSVLSLASNASSNYSNE 1028

  Fly  1776 EERQAHEIRRLKRELQDARDQVLSLSSQLSTN---AHVVTAFEQSLSNMTNRLHQLTATAERKDG 1837
            |..|..:||.|:|||:.::|:|.:|::||:.|   |::|.||||||:.||.||..|:.|:|:||.
Zfish  1029 ERMQGEQIRILRRELESSQDKVANLTTQLAANAGQANLVAAFEQSLALMTARLQSLSVTSEQKDT 1093

  Fly  1838 ELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRA 1902
            ||.|:::|||:|:.::                |:.|..:.|     ||..|  |..|...|  ||
Zfish  1094 ELQDLKETIEVLKTKN----------------TEAQTLIHG-----ALSTP--DPMPKEEG--RA 1133

  Fly  1903 INANNGSMPLGMQRQHSTDSMCSLNSISSGCSAA---QDKNKANKKKGW---LRSSFTKAFSRNA 1961
            ..|  .:..|.:.||:|::|:.|||||:|..||.   :.:.|..|||.|   |||||.||||:..
Zfish  1134 FTA--CASELQIDRQNSSESISSLNSITSHSSAGSLKEQEAKKKKKKSWVYELRSSFNKAFSKKG 1196

  Fly  1962 KISKTSRHVGHHHHHNHSQQELASGKLPLHNGHGEPLGLASLATQPAPPLPNSKQSSP------- 2019
            .                        |.|..:       :..:||..|     |..|||       
Zfish  1197 P------------------------KAPYAD-------IEEIATPEA-----SAPSSPKIHHNVD 1225

  Fly  2020 -----AKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEALSSASQLESLKEMMN 2079
                 |.|.||..:....:..:: |:.||.:|:.:|.||:..||||||||||||.|||.|:|.|.
Zfish  1226 NTFTKASTSTLGRSCGGPEETER-DEKVVSELRSELWEKERKLTDIRLEALSSAHQLEQLQEAMT 1289

  Fly  2080 KMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVAGSSEVSRRYSLADSNSRPPMEL 2144
            .|:..:.:||..|::|:        .|...|...:.:...|..||..||                
Zfish  1290 NMQLTVENLKAENDQLK--------TGGPTSRPPSSTSQSSGLGSLGVS---------------- 1330

  Fly  2145 PARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPVHMAS 2209
                               :|.|         ||:..|.:.....|.|.|.:    ..||.....
Zfish  1331 -------------------SPRQ---------SVSSFSKTAGTGQTEPYPDV----FHSPTSTLQ 1363

  Fly  2210 ATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYANGHEADSQSQSERKSNYTSASCNE 2274
            ..|.|        :.:...:...:.|.   :|:::|                            |
Zfish  1364 KDESL--------VRVLVRIPNQQLFK---DEVKQL----------------------------E 1389

  Fly  2275 FVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGFPELL 2339
            |.|....|||:|.|.:||..|.:.||:|::.:|||::|||:.|||.||.|...||......||..
Zfish  1390 FFIGSVRISGRTDWFSLDSAVIQAFKEYLSVVDPGSSLGLSQDSIYSYSLSHLKRVLGAQPPETP 1454

  Fly  2340 PCGYIVGSVRTLYICLQG-----VGSLAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGKSYLA 2399
            |..........:.:.|:|     |..|.|::|:|:.::..|||||.:||||||.|||||||:||.
Zfish  1455 PVRLYSRGQACITVALKGLKEKCVDVLVFETLVPKPMMQHYISLLLKHRRLILSGPSGTGKTYLT 1519

  Fly  2400 RRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDNLHHA 2464
            .||||:||.||||........|||:..:|.|||:.||.::|.|....:..:|:|.|:|||::|..
Zfish  1520 YRLAEYLVERSARELTPAITNTFNMHRQSCKDLQLYLANLANQIDRESSTAEIPLVVILDDVHEP 1584

  Fly  2465 SALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRFLRRR 2529
            ::|.::.:..|:. ..:|.|.||||.:|....:.|..||.:||.|..:|::||..|||.|:|.|:
Zfish  1585 TSLSELVNGALTC-KYHKCPYIIGTTNQPVKMSPNHGLHLSFRMVTFSNNVEPANGFLVRYLHRK 1648

  Fly  2530 LFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDI 2594
            |.:.|........:|..||.|:|.:|.|::.|||.||:||..|||..||:||:.::|.:.||.|:
Zfish  1649 LMEAEDPRSVTNEDLLRVLDWVPRLWYHLHTFLEKHSTSDFLIGPCFFLSCPVTVEDFRTWFIDL 1713

  Fly  2595 WNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPYG-----------PDSVPPLRQIN 2648
            ||:.:.|||.|..::|::::|:: ..|.||..::|.|.|||..           |.|..|.....
Zfish  1714 WNHSIIPYLQEGSKDGIKVHGQK-SVWEDPVEWVRGSLPWPSAQQDQAKLFHLPPPSTGPGSPSQ 1777

  Fly  2649 AEDVGLEGVALTNGDQQDPLLNMLMRLQEAANYSEAQDQESD 2690
            ..|.........:..:.|||:.||::||||||:.|:.::|:|
Zfish  1778 PADERTHKETPPSSVESDPLMAMLLKLQEAANHIESPEKETD 1819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479
AAA 2382..2531 CDD:214640 67/148 (45%)
AAA_22 2385..2476 CDD:290137 41/90 (46%)
nav1bXP_017212240.1 P-loop_NTPase 1488..>1519 CDD:304359 20/30 (67%)
AAA 1501..1612 CDD:214640 51/111 (46%)
AAA 1505..1612 CDD:99707 48/107 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 368 1.000 Domainoid score I867
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 1 1.000 - - otm24695
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - O PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X908
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
88.000

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