Protein Alignment CG10481 and XPR1

DIOPT Version :10

• Sequence 1: NP_995731.1
• Gene: CG10481 / 35273
• FlyBaseID: FBgn0032827
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_004727.2
• Gene: XPR1 / 9213
• HGNCID: 12827
• Length: 696
• Species: Homo sapiens
• Alignment Length: 689
• Identity: 257/689 - (37%)
• Similarity: 373/689 - (54%)
• Gaps: 72/689 - (10%)

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |||.:.|...:.||||.||:.|...|.|:.:|.::|||......|....|:..|||.||.:|..|
Human     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQLDRR-RAQQDPRGSTASRGSASSWSRQP------EGKRKF 123
            |.|:|.|::.|.|||.|:.|||..:|... .||::..|.|..|     ..|:|      |.:.:.
Human    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLR-----QRRKPVFHLSHEERVQH 125

  Fly   124 PPIKKLRLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQ 188
            ..||.|:||.||||||||:|||||.||.|.||||.||:||.|::..|..|...:|..:......:
Human   126 RNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKK 190

  Fly   189 LDRMISTTENMYTDYLANGDRSEAMAKLRVPPLG--HPTPPVHVFSAGLFLGLFLVSAI-LCFIS 250
            ::::||.||.:.|:.|.:|||.:||.:|||||||  .|.|....|..|||.|:|:|..| |...:
Human   191 INQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAA 255

  Fly   251 YFAVDTSPEFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEI 315
            .|.::|.... :..:.::||....:.|.|.|.||...:...|||.|||||:..|:.:......||
Human   256 VFKLETDRSI-WPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEI 319

  Fly   316 SSFFGYMCTLSILLYLLHKEFFIEDPIYI-PLVQVAFVVVLFLNPFRILFYSGRIWLLTVMGRIL 379
            :.|.|.:..||:|.........|  |.|: ||....|:|...:||.:..:|..|.|||.::.|:.
Human   320 AGFLGILWCLSLLACFFAPISVI--PTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVF 382

  Fly   380 LSPFFFVNFADFWVADQWTSLVVTIVDHYYLVRFYVRYFLDRSDAFEFEPD-------------- 430
            .:||..|.|||||:|||..||.|.::|..|::.||         :.|.:.|
Human   383 TAPFHKVGFADFWLADQLNSLSVILMDLEYMICFY---------SLELKWDESKGLLPNNSEESG 438

  Fly   431 ------YAV-AVIRCLPAWFRFAQSLRRFRDSGSKSTDYLINALKY----FLFIAEVVFSTIQME 484
                  |.| |:::|:|||.||.|.|||:||: .::..:|:||.||    |:.....::||
Human   439 ICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDT-KRAFPHLVNAGKYSTTFFMVTFAALYST---- 498

  Fly   485 TIAH----YTDLFESPWTWAYITICIVSSIYTVFWDLLMDFGLFRVWNGENKFLRDNLVYP-RWF 544
               |    ::|.....:.|  |...|:||.||:.|||.||:|||....|||.|||:.:||| :.:
Human   499 ---HKERGHSDTMVFFYLW--IVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAY 558

  Fly   545 YYFVIVENTLLRCVWILEFALVHQELIAPYNG---KSLICFSEIARRFFWNFLRLENEHLYNCGQ 606
            ||..|:|:.:||..|.::.::....|: |::|   .::....|:.|||.|||.|||||||.|||:
Human   559 YYCAIIEDVILRFAWTIQISITSTTLL-PHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGE 622

  Fly   607 FRATRDIFITRLDPQEERFLESVMDNTEDLGREKLNKKY 645
            |||.|||.:..|:..::..||.:||..:.:...:.|:.:
Human   623 FRAVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRSW 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	73/167 (44%)
		EXS	267..601	CDD:460816	129/367 (35%)
XPR1	NP_004727.2	SPX_XPR1_like	2..165	CDD:269898	73/167 (44%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000269|PubMed:39169184, ECO:0000269|PubMed:39325866	158..165		4/6 (67%)
		EXS	268..617	CDD:460816	129/370 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..696