DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10481 and XPR1

DIOPT Version :9

Sequence 1:NP_995731.1 Gene:CG10481 / 35273 FlyBaseID:FBgn0032827 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_004727.2 Gene:XPR1 / 9213 HGNCID:12827 Length:696 Species:Homo sapiens


Alignment Length:689 Identity:257/689 - (37%)
Similarity:373/689 - (54%) Gaps:72/689 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |||.:.|...:.||||.||:.|...|.|:.:|.::|||......|....|:..|||.||.:|..|
Human     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQLDRR-RAQQDPRGSTASRGSASSWSRQP------EGKRKF 123
            |.|:|.|::.|.|||.|:.|||..:|... .||::..|.|..|     ..|:|      |.:.:.
Human    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLR-----QRRKPVFHLSHEERVQH 125

  Fly   124 PPIKKLRLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQ 188
            ..||.|:||.||||||||:|||||.||.|.||||.||:||.|::..|..|...:|..:......:
Human   126 RNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKK 190

  Fly   189 LDRMISTTENMYTDYLANGDRSEAMAKLRVPPLG--HPTPPVHVFSAGLFLGLFLVSAI-LCFIS 250
            ::::||.||.:.|:.|.:|||.:||.:|||||||  .|.|....|..|||.|:|:|..| |...:
Human   191 INQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAA 255

  Fly   251 YFAVDTSPEFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEI 315
            .|.::|.... :..:.::||....:.|.|.|.||...:...|||.|||||:..|:.:......||
Human   256 VFKLETDRSI-WPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEI 319

  Fly   316 SSFFGYMCTLSILLYLLHKEFFIEDPIYI-PLVQVAFVVVLFLNPFRILFYSGRIWLLTVMGRIL 379
            :.|.|.:..||:|.........|  |.|: ||....|:|...:||.:..:|..|.|||.::.|:.
Human   320 AGFLGILWCLSLLACFFAPISVI--PTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVF 382

  Fly   380 LSPFFFVNFADFWVADQWTSLVVTIVDHYYLVRFYVRYFLDRSDAFEFEPD-------------- 430
            .:||..|.|||||:|||..||.|.::|..|::.||         :.|.:.|              
Human   383 TAPFHKVGFADFWLADQLNSLSVILMDLEYMICFY---------SLELKWDESKGLLPNNSEESG 438

  Fly   431 ------YAV-AVIRCLPAWFRFAQSLRRFRDSGSKSTDYLINALKY----FLFIAEVVFSTIQME 484
                  |.| |:::|:|||.||.|.|||:||: .::..:|:||.||    |:.....::||    
Human   439 ICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDT-KRAFPHLVNAGKYSTTFFMVTFAALYST---- 498

  Fly   485 TIAH----YTDLFESPWTWAYITICIVSSIYTVFWDLLMDFGLFRVWNGENKFLRDNLVYP-RWF 544
               |    ::|.....:.|  |...|:||.||:.|||.||:|||....|||.|||:.:||| :.:
Human   499 ---HKERGHSDTMVFFYLW--IVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAY 558

  Fly   545 YYFVIVENTLLRCVWILEFALVHQELIAPYNG---KSLICFSEIARRFFWNFLRLENEHLYNCGQ 606
            ||..|:|:.:||..|.::.::....|: |::|   .::....|:.|||.|||.|||||||.|||:
Human   559 YYCAIIEDVILRFAWTIQISITSTTLL-PHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGE 622

  Fly   607 FRATRDIFITRLDPQEERFLESVMDNTEDLGREKLNKKY 645
            |||.|||.:..|:..::..||.:||..:.:...:.|:.:
Human   623 FRAVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRSW 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10481NP_995731.1 SPX_XPR1_like 2..163 CDD:269898 73/167 (44%)
SPX 3..163 CDD:281146 72/166 (43%)
EXS 267..601 CDD:281164 129/367 (35%)
XPR1NP_004727.2 SPX_XPR1_like 2..165 CDD:269898 73/167 (44%)
Important for inositol polyphosphate binding. /evidence=ECO:0000250|UniProtKB:P43585 158..165 4/6 (67%)
EXS 268..617 CDD:367343 129/370 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5409
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.569298 Normalized mean entropy S1995
OMA 1 1.010 - - QHG54286
OrthoDB 1 1.010 - - D125160at33208
OrthoFinder 1 1.000 - - FOG0000547
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10783
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X439
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.840

Return to query results.
Submit another query.