DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10481 and SYG1

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_012217.3	Gene:	SYG1 / 854764	SGDID:	S000001309	Length:	902	Species:	Saccharomyces cerevisiae

Alignment Length:	828	Identity:	186/828 - (22%)
Similarity:	303/828 - (36%)	Gaps:	244/828 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEK----------------------------AP 37
            |||...|....:||||.:|::|...|:.:|...||                            .|
Yeast     1 MKFADHLTESAIPEWRDKYIDYKVGKKKLRRYKEKLDAEEEQSSSYRSWMPSVSVYQTAFQQREP 65

  Fly    38 SGSRPSNDVAIG---------YYRNFEELFFNSCRV--ELTKVNYFFAHKQAEAHRKLATL---- 87
            ..||...|...|         ..|.|...|.....:  :|:|.|.|:.....|..:|...|
Yeast    66 GKSRSDGDYRSGPAFKKDYSALQREFVADFIEDWLISFQLSKCNEFYLWLLKECDKKFEVLQSQL 130

  Fly    88 -------NYQ---LDRRRAQQDPRGSTASRGSAS------------------------------- 111
                   ||:   |:|..:..|...|..:.|.|.
Yeast   131 HYYSLQKNYERDNLNRSSSNVDMSTSLYAAGLAGRSDSRVNSIDSDSRSVMYGSMPCTKEAKKPR 195

  Fly   112 ------------------SWSRQPEGKRKFPPIKKLRL--------------------------- 131
                              ||.     ||.|..::.||.
Yeast   196 LSLLAYCQKVLKDNRLLPSWP-----KRGFSLLQDLRQDASSRGRETFAFGASFLETMTTTQARN 255

  Fly   132 ----AMSEFYLSLIMLQNYQTLNMTAFRKICKKYDK--NLKSEAGFAWYEK--YVL----KSTLA 184
                |:.|:||.|.::::::.:|:|.|||:.||:||  :.:....|..|.:  |.|    .:.:.
Yeast   256 LLSNAIIEYYLYLQLVKSFRDINVTGFRKMVKKFDKTCHTRELTTFMSYARTHYTLFKHADANVQ 320

  Fly   185 ITLQLDRMISTTE-------------------------NMYTDYLANG--DRSEAMAKLRVPPLG 222
            :..|..:.|::::                         ..:|..|.|.  ||.....||:...:.
Yeast   321 LVAQKMQQITSSQPTPTSELSSAQRDKEPITWLETQITEWFTTALTNSPKDRKHNTHKLKKLTIQ 385

  Fly   223 HPTPP----------VHVFSAGLFLGLFLVSAILCFISYFAVDTSPEFRYTFVSLFRGPISG--- 274
            :....          |.:...||.:|:.:  .::.:..|..: :|.|..:|...||  |:.|
Yeast   386 YSISEQMVHRNNRSIVQMLVVGLGIGVSM--TLITYTLYLGI-SSEETSFTHKILF--PLWGGWY 445

  Fly   275 --VTFGFCLAINIKVYETVGVNQ--VLIFEVERRNAIGAMR----------ALEISSFFGYMCTL 325
              :...|...:|..::...|:|.  :::.|::.:|......          .|...:||...|.:
Yeast   446 MVLLIAFLFLVNCFIWHRTGINYRFIMLGEIQSKNGTQFFNNDFATSKIPLKLYFLTFFIVPCAV 510

  Fly   326 SILLYLLHKEFFIEDPIYIPLVQVAFVVVLFLNPFRILFYSGRI-----WLLTVMGRILLSPFFF 385
            ..:|     .|.:|....:..:.:..|..|||.|..::.|..::     ||:..:.|:::|.||.
Yeast   511 CSML-----SFALEKLTPLGFLYIGIVSFLFLCPSGLIPYWDKVVHTRKWLVVTLIRLMMSGFFP 570

  Fly   386 VNFADFWVADQWTSLVVTIVDHYYLVRFYVRYFLDRSDAFEFEPDYAVAVIRCLPAWFRFAQSLR 450
            |.|.||::.|...||..:|.|   :..|:..|....::........|:.|:.|||:::||.|.||
Yeast   571 VEFGDFFLGDIICSLTYSIAD---IAMFFCVYSHTPNNLCGSSHSRAMGVLSCLPSYWRFMQCLR 632

  Fly   451 RFRDSGSKSTDYLINALKYFLFIAEVVFSTIQMETIAHY--TDLFESPWTWAYITICIVSSIYTV 513
            ||.|||. ...:|:||.||.|.||       ...|:..|  :|..|...| .:|....::||.|.
Yeast   633 RFADSGD-WFPHLLNAAKYTLGIA-------YNATLCAYRLSDRSEQRRT-PFIVCATLNSILTS 688

  Fly   514 FWDLLMDFGLFRVWNGENKFLRDNLVY---PRW-----------FYYFVIVENTLLRCVWILEFA 564
            .|||:||:.........|..|||:|..   ..|           .|||.::.:.|:|..||: :|
Yeast   689 AWDLVMDWSFAHNTTSYNWLLRDDLYLAGKKNWENGSYSFSRKLVYYFAMIWDILIRFEWIV-YA 752

  Fly   565 LVHQELIAPYNGKSLICFSEIARRFFWNFLRLENEHLYNCGQFRATRD 612
            :..|.:........::...|:.|||.|...|:||||:.|...||.|.|
Yeast   753 IAPQTIQQSAVTSFILALLEVLRRFVWIIFRVENEHVANVHLFRVTGD 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	55/293 (19%)
		SPX	3..163	CDD:281146	54/292 (18%)
		EXS	267..601	CDD:281164	101/371 (27%)
SYG1	NP_012217.3	COG5408	1..310	CDD:227695	60/313 (19%)
SYG1	NP_012217.3	COG5409	402..803	CDD:227696	114/422 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I970
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I809
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		otm46759
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
TreeFam	1	0.960	-	-
	11	10.870