DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10481 and VTC2

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_116651.1	Gene:	VTC2 / 850544	SGDID:	S000001890	Length:	828	Species:	Saccharomyces cerevisiae

Alignment Length:	194	Identity:	53/194 - (27%)
Similarity:	70/194 - (36%)	Gaps:	49/194 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |.||..|.|.:.|.|:..|:||..||:.:     |..|....|||....:..:.|..|......|
Yeast     1 MLFGVKLANEVYPPWKGSYINYEGLKKFL-----KEDSVKDGSNDKKARWDDSDESKFVEELDKE 60

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQLDRRRAQQDPRGSTASRGSASSWSRQPEGKRKFPPIKKL- 129
            |.||..|...|......:|:.|..|.|...|                             ||.|
Yeast    61 LEKVYGFQLKKYNNLMERLSHLEKQTDTEAA-----------------------------IKALD 96

  Fly   130 ----RLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKY-VLKSTLAITLQ 188
                :..:.|.......|.|::.||.|.|.||.||:||         .|.|| .:||.|.:.|:
Yeast    97 ADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDK---------LYPKYPSVKSLLEVRLK 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	43/165 (26%)
		SPX	3..163	CDD:281146	43/164 (26%)
		EXS	267..601	CDD:281164
VTC2	NP_116651.1	COG5036	1..555	CDD:227369	53/194 (27%)
VTC2	NP_116651.1	VTC1	662..791	CDD:227589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.790