DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10481 and xpr1b

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001119862.1	Gene:	xpr1b / 558034	ZFINID:	ZDB-GENE-060503-266	Length:	693	Species:	Danio rerio

Alignment Length:	676	Identity:	261/676 - (38%)
Similarity:	374/676 - (55%)	Gaps:	50/676 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |||.:.|...:.||||.||:.|...|:|:.:|.::|||......|....||..|||.||.:|..|
Zfish     1 MKFTEHLSAHITPEWRKQYIQYEAFKEMLYSAQDQAPSIEVTDEDTVKRYYAKFEEKFFQTCEKE 65

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQLDRR-RAQQDPRGSTASRGSASSWSRQPEGKRKFPPIKKL 129
            |.|:|.|::.|.|||.|:.|||..:|... .||::...:...|...:.:....:.:.|...||.|
Zfish    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDAQRESSRAAGLRHRRTVFHLSQQERCKHRNIKDL 130

  Fly   130 RLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQLDRMIS 194
            :||.||||||||:|||||.||.|.||||.||:||..::..|..|...:|..:......::.::||
Zfish   131 QLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKIFETSRGADWRVAHVEVAPFYTCKKITQLIS 195

  Fly   195 TTENMYTDYLANGDRSEAMAKLRVPPLG--HPTPPVHVFSAGLFLGLF-------LVSAILCFIS 250
            .||.:.|..|..|||.:||.:|||||||  .|.|....|..||:.|:|       :::.::..:.
Zfish   196 ETETLVTTELEGGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGVFVALTVTVIIAGVVKLVE 260

  Fly   251 YFAVDTSPEFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEI 315
            :|..:|..   :..:.::||....:.|.|.|.||...:...|||.|||||:..||.:......||
Zfish   261 HFGDNTDV---WPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEI 322

  Fly   316 SSFFGYMCTLSILLYLLHKEFFIEDPIYI-PLVQVAFVVVLFLNPFRILFYSGRIWLLTVMGRIL 379
            :.|.|.:..:|||..|..:...|  ||:: ||....|..:..:||.:..:|..|.|||.::.|::
Zfish   323 AGFLGVLWCVSILSCLFAENTLI--PIHMNPLALYGFFFLFLINPLKTCYYKSRFWLLKLLFRVV 385

  Fly   380 LSPFFFVNFADFWVADQWTSLVVTIVDHYYLVRFYV----------RYFLDRSDAFEFEPDYAV- 433
            .:||..|.|||||:|||..||||.::|..|::.||.          ..::...:...:...|.|
Zfish   386 TAPFHRVGFADFWLADQLNSLVVVLMDLEYMICFYSLELNWTMSEGELWIKEGERICYSYSYGVR 450

  Fly   434 AVIRCLPAWFRFAQSLRRFRDSGSKSTDYLINALKY----FLFIAEVVFSTIQMETIAHYTDLFE 494
            |||:||||||||.|.|||:||: .::..:|:||.||    |:.|.|.:|.|       |..|
Zfish   451 AVIKCLPAWFRFVQCLRRYRDT-KRAFPHLVNAGKYSTTFFVVIFEALFKT-------HSGD--- 504

  Fly   495 SPWTWAYITIC--IVSSIYTVFWDLLMDFGLFRVWNGENKFLRDNLVYP-RWFYYFVIVENTLLR 556
            ..:.:.||.|.  ||:|.||:.|||.||:|||....|||..||:.:||| :.:||..|||:.:||
Zfish   505 ERFVFLYIMIACRIVNSCYTLLWDLKMDWGLFDRNAGENTLLREEIVYPQKAYYYCAIVEDVILR 569

  Fly   557 CVWILEFAL---VHQELIAPYNGKSLICFSEIARRFFWNFLRLENEHLYNCGQFRATRDIFITRL 618
            ..|.:..:|   ..:.:|:...| :::...|:.|||.|||.|||||||.|||:|||.|||.:..|
Zfish   570 FAWTIPLSLEVVYDRPVISNILG-TVLPPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPL 633

  Fly   619 DPQEERFLESVMDNTEDLGREKLNKK 644
            :..::..||.:||. ||..|.:|.||
Zfish   634 NADDQTLLEQMMDQ-EDGVRNRLGKK 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	70/161 (43%)
		SPX	3..163	CDD:281146	69/160 (43%)
		EXS	267..601	CDD:281164	136/355 (38%)
xpr1b	NP_001119862.1	SPX_XPR1_like	2..164	CDD:269898	70/161 (43%)
		SPX	3..172	CDD:281146	71/168 (42%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	157..164		4/6 (67%)
		EXS	289..616	CDD:281164	131/340 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..693
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.820