DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10481 and xpr1

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001016753.1	Gene:	xpr1 / 549507	XenbaseID:	XB-GENE-1015946	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	677	Identity:	245/677 - (36%)
Similarity:	364/677 - (53%)	Gaps:	74/677 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |||.:.|...:.||||.||:.|...|:|:..|.::|||......|....||..|||:||.:|..|
Frog     1 MKFAEHLSAHITPEWRKQYIQYEAFKEMLYAAQDQAPSIEVTDEDTVKRYYAKFEEIFFQTCEKE 65

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQ----LDRRRAQQDPRGSTASRGSASSWSRQPEGKRKFPPI 126
            |.|:|.|::.|.|||.|:.|||..:    ||.:|......|....|.:..:.:.:...:.:  .|
Frog    66 LAKINTFYSEKLAEAQRRSATLQNELQSSLDAQRESSAIPGLRQRRKAVFALTHEERVQHR--NI 128

  Fly   127 KKLRLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQLDR 191
            |.|:||.||||||||:|||||.||.|.||||.||:||.|::..|..|...:|..:......::::
Frog   129 KDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQ 193

  Fly   192 MISTTENMYTDYLANGDRSEAMAKLRVPPLG--HPTPPVHVFSAGLFLGLFLV--SAILCFISYF 252
            :||.||.:.|:.|.:|||.:||.:|||||||  .|.|....|..||:.|:|:|  .||:...|::
Frog   194 LISETETVVTNELESGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGIFIVLNMAIIMAGSHY 258

  Fly   253 AV--DTSPEFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEI 315
            .:  |..|     .|.::||....:.|.|.|.||...:...|||.|||||:..||.:......||
Frog   259 LLGKDVWP-----MVRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEI 318

  Fly   316 SSFFG-------YMCTLSILLYL-LHKEFFIEDPIYIPLVQVAFVVVLFLNPFRILFYSGRIWLL 372
            :.|.|       :.|...:.:.| :|..         ||:....:::..:||.:..:|..|.|||
Frog   319 AGFLGILWCFSLFSCIFGLWINLQMHLN---------PLILYGLMLLFLVNPTKTFYYKSRFWLL 374

  Fly   373 TVMGRILLSPFFFVNFADFWVADQWTSLVVTIVDHYYLVRFYVRYFLDRSDAFEFE--------- 428
            .::.|:..:||..|.|||||:|||..||.|.::|..:::.||         :||.:
Frog   375 KLLFRVFTAPFHKVGFADFWLADQLNSLAVILMDLEFMICFY---------SFELKWGDSDGLVN 430

  Fly   429 --------PDYAV-AVIRCLPAWFRFAQSLRRFRDSGSKSTDYLINALKY----FLFIAEVVFST 480
                    ..|.| ||::|:|||.||.|.|||:||: .::..:|:||.||    |:.....::||
Frog   431 SANSVCNSYSYGVRAVVQCIPAWLRFIQCLRRYRDT-KRAFPHLVNAGKYSTTFFMVTFAALYST 494

  Fly   481 IQMETIAHYTDLFESPWTWAYITICIVSSIYTVFWDLLMDFGLFRVWNGENKFLRDNLVYP-RWF 544
            .:..   :::|.....:.|  |...::||.||:.|||.||:|||....|||.|||:.:||| :.:
Frog   495 HKER---NHSDAQVFFYLW--IIFYLISSCYTLIWDLKMDWGLFDRNAGENTFLREEIVYPQKAY 554

  Fly   545 YYFVIVENTLLRCVWILEFALVHQELIAPYNG--KSLICFSEIARRFFWNFLRLENEHLYNCGQF 607
            ||..|:::.:||..|.::.::....|......  .:::...|:.|||.|||.|||||||.|||:|
Frog   555 YYCAIIQDVILRFAWTIQISVTSLNLFTDAGDIISTVLAPLEVFRRFVWNFFRLENEHLNNCGEF 619

  Fly   608 RATRDIFITRLDPQEERFLESVMDNTE 634
            ||.|||.:..|:..::..||.:||..:
Frog   620 RAVRDISVAPLNADDQTLLEQMMDQDD 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	70/164 (43%)
		SPX	3..163	CDD:281146	69/163 (42%)
		EXS	267..601	CDD:281164	120/366 (33%)
xpr1	NP_001016753.1	SPX_XPR1_like	2..165	CDD:269898	70/164 (43%)
		SPX	3..169	CDD:281146	72/167 (43%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	158..165		4/6 (67%)
		EXS	269..613	CDD:281164	120/367 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030