DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10481 and Y39A1A.22

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_499359.3	Gene:	Y39A1A.22 / 3565273	WormBaseID:	WBGene00012659	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	233/710 - (32%)
Similarity:	343/710 - (48%)	Gaps:	107/710 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            ||||:.|.:.:.||||.||::|..||.::.:.:.:.|:    .:|....:....:|.|||.|..|
Worm     1 MKFGEQLASHLTPEWRKQYIDYERLKNLLYDDMMEVPA----DDDRREEHISRLDEKFFNECDQE 61

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQLDRRRAQQDPRGSTASRGSASSWSRQPEGKRKFPP----- 125
            |||:|.||:.|.||...|...|..:|   :..:|..|   ||...:...|:..||.||..
Worm    62 LTKINLFFSQKIAEGQGKHHELQTEL---QVFKDVLG---SRSDTTGIRRRFGGKDKFHKETTRN 120

  Fly   126 IKKLRLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQLD 190
            .::|:||.|||||||:::||:|.||.|.||||.||:||...:|.|..|....|.||:..:..:::
Worm   121 EQQLKLAFSEFYLSLVLVQNFQQLNATGFRKILKKHDKLTGNERGLDWRINKVEKSSFFLNREIE 185

  Fly   191 RMISTTENMYTDYLANGDRSEAMAKLRVPPLGHPTPPVHVFSAGLFLGLFLVSAILCFISYFAVD 255
            .:|:..|....:.|..|:|...|.:|:||||.....|:..||.|||:|..::..:...:::.|..
Worm   186 TLITNVETSVINDLEAGNRQAGMKRLKVPPLSEKQKPLTTFSLGLFIGASIILLLAILLTWIASP 250

  Fly   256 TSP-EFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEISSFF 319
            ..| |.::..|.|||||:......|...:|:..:...|||.||||||:.||.:.....::|:||.
Worm   251 ARPQEPKWVAVRLFRGPLLLFLSIFLCGVNMAGWAAAGVNHVLIFEVDPRNHLSYQTLMQIASFM 315

  Fly   320 GYMCTLSILLYLLHKEFFIEDPIYIPLVQVAFVVVLFLNPF----RILFYSGRIWLLTVMGRILL 380
            ..:.:.::|.||......| .|...||..:...::|.|||.    .:...:.|.|||....:...
Worm   316 IMLWSFAVLAYLYAHMLHI-PPFAPPLALMVVCLILLLNPIAKPDSVFHRNSRFWLLKHCYKCFT 379

  Fly   381 SPFFFVNFADFWVADQWTSLVVTIVDHYYLVRFYVRYFLDRSDAFEFEPDY-------------- 431
            |||.||.|.|||:.||..||....:|..|.|.||..           |.||
Worm   380 SPFHFVTFTDFWLGDQMNSLTTAFLDFQYFVCFYAT-----------EVDYSNGWIEVKGINSTT 433

  Fly   432 ------------------AVAVIRCL----PAWFRFAQSLRRFRDSGSKSTDYLINALKY---FL 471
                              :.|.:|.|    ||..||.|.|||:||: .:...:|:||.||   |.
Worm   434 GSVPWGSVELSNGKDQCASAAGLRSLMSIIPAMIRFLQCLRRYRDT-KRVHPHLVNAGKYSTTFF 497

  Fly   472 FIAEVVFSTIQMETIAHYTDLFESPWTWAYITICIVSSIYTVFWDLLMDFGLF--RVWNGENKFL 534
            .:|....:.....|..:.|.:|...|..:|    |:|..||..||:.||:||.  |. ..|.:||
Worm   498 VVACGALNKYYEATDPNTTSIFFYIWILSY----IMSFTYTFLWDIFMDWGLIDPRA-PKEARFL 557

  Fly   535 RDNLVY-PRWFYYFVIVENTLLRCVWILEFALVH---------QELIAPYNGKSLICFSEIARRF 589
            |:.::| .:|:||..|.::.:||..|:|..:|..         ..:.||:         |:.|||
Worm   558 REEMIYGSKWYYYMAIAQDFVLRLAWVLNVSLGEAWTLDSDFLTTVTAPF---------EVFRRF 613

  Fly   590 FWNFLRLENEHLYNCGQFRATRDIFITRLDPQEERFLESV------MDNTEDLGREKLNK 643
            .||:.||||||:.|||||||.|||.:   .|..:..|||:      ||.....|::.:.:
Worm   614 IWNYFRLENEHVNNCGQFRAVRDISV---KPIRKGDLESLLSKMDQMDGVTHRGQDLMER 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	64/165 (39%)
		SPX	3..163	CDD:281146	63/164 (38%)
		EXS	267..601	CDD:281164	120/388 (31%)
Y39A1A.22	NP_499359.3	SPX_XPR1_like	2..158	CDD:269898	64/165 (39%)
Y39A1A.22	NP_499359.3	EXS	262..625	CDD:308637	120/389 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.840