DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10481 and SPCC1827.07c

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_588554.2	Gene:	SPCC1827.07c / 3361154	PomBaseID:	SPCC1827.07c	Length:	682	Species:	Schizosaccharomyces pombe

Alignment Length:	717	Identity:	187/717 - (26%)
Similarity:	295/717 - (41%)	Gaps:	122/717 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPS----------GSRPSND-VAIGYYRNF 54
            |||||.::...|.||...|.:|.:.|::|. .:.|.||          |..|... |..|....|
pombe     1 MKFGKVIEGQSVAEWASAYFDYKKGKKIIA-GIAKNPSEGLYGTSGILGETPEEAIVKRGQIHRF 64

  Fly    55 EELFFNSCRVELTKVNYFFAHKQAEAHRKLATLNYQLDRRRAQQDPRGSTASRGSASSWSRQPEG 119
            ..||......:..||..||.:..::|..::..::.|:|.....:..:..|...||.....:|...
pombe    65 HPLFQEFLDQQANKVEEFFENLVSDARERMDLISDQVDIYEKLRAFKKGTLESGSVVLIQKQHSK 129

  Fly   120 KRK---------------------------FPPI-------KKLRLAMSEFYLSLIMLQNYQTLN 150
            .|:                           :.|:       .||:..:.:||..|.::..||.||
pombe   130 LRQRLDSILNFSRLQPAYHIPARKSVPTDAYTPMVSYRKLKSKLKTTLLDFYDYLKLVSQYQHLN 194

  Fly   151 MTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQLDRMIST-----TENMYTDYLANGDRS 210
            ..|||||.|||||.|.::....|.: |:.:.|..     |..|:|     .|::|.....|.::
pombe   195 QQAFRKIVKKYDKTLHTDLQGFWVD-YMSRYTFT-----DFSITTNWQLHVEDIYARLFTNHNK- 252

  Fly   211 EAMAKLRVPPLGHPTPPVHVFSA-----GLFLGLFLVSAILCFISYFAVDTSPEFRYTFVSLFRG 270
                ||.:..|.......| |||     ||..|..|..||.....|.|.:.|     :::....|
pombe   253 ----KLALEHLKSFRQKEH-FSANSMRFGLLFGAGLPLAIEAACYYNATEQS-----SYLLQIWG 307

  Fly   271 PISGVTFGFCL-AINIKVYETVGVNQVLIFEVERRNAIGAMRALEI--SSFFGYMCTLSILLYLL 332
            ....|.|.|.| .::..|:|...||.:||||..:|.::...:.|||  :.||    ..|:..:|.
pombe   308 GFFLVIFAFVLFDLDCYVWEKTRVNYMLIFEFNQRKSLNWRQHLEIVGAVFF----IFSLFFFLC 368

  Fly   333 HKEFFIEDPIYIPLVQVAFVVVLFLNPFRILFYSGRIWLLTVMGRILLSPFFFVNFADFWVADQW 397
            .:.||....||.|.:.:..|....:.|..:.::..|.:|:..:.|:.||....|:|.||:.|||.
pombe   369 MRNFFPGFTIYFPALFLGVVGTFLIAPVIVPYWRMRRYLIIQLIRVFLSGLSTVHFQDFFFADQM 433

  Fly   398 TSLVVTIVDHYYLVRFYVRYFLDRSDAFEFEPDYA-------VAVIRCLPAWFRFAQSLRRFRDS 455
            .||.....:.......|.|.:.        :|...       :.....||...|..|..||:.||
pombe   434 VSLTYACGNISLFFCLYKRLWR--------QPQLCNSSHSPLLGFFTTLPGILRVFQCFRRYSDS 490

  Fly   456 GSKSTDYLINALKY-FLFIAEVVFSTIQMETIAHYTDLFESPWTWAYITICIVSSIYTVFWDLLM 519
             .||..:|:||||| |..:|::..|..::.....|..|        |.....|:|:::..||:||
pombe   491 -LKSFPHLVNALKYIFNILAQMFLSLWRIHPGLKYRVL--------YTIFAGVNSLFSYTWDILM 546

  Fly   520 DFGLFRVWNGENKFLRDNLVYPRWFYYFVIVENTLLRCVWILEFALVHQELIAPYNGKS-LICFS 583
            |:.|....:|..:|....::...|.|...::.|.::|..:|  |..:....|...:|.| .:..:
pombe   547 DWNLLVRKDGRWQFREHRILKQLWPYIIAMILNFIVRSSFI--FYCIFPNHIQHSSGISFFVTLA 609

  Fly   584 EIARRFFWNFLRLENEHLYNCGQFRATR------------DIFITRLDPQEERFL--ESVMDNTE 634
            ||.||..||.||:|:|.:||....||.|            |:|::.....::.:.  |..||:..
pombe   610 EIMRRCMWNILRVEHEEIYNRENLRAARELKPLDFVKPHSDVFVSHQISSDKNYTDDEDSMDDQT 674

  Fly   635 DL 636
            |:
pombe   675 DV 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	51/205 (25%)
		SPX	3..163	CDD:281146	50/204 (25%)
		EXS	267..601	CDD:281164	96/345 (28%)
SPCC1827.07c	NP_588554.2	COG5408	1..272	CDD:227695	71/283 (25%)
		SPX_SYG1_like	2..207	CDD:269896	51/205 (25%)
		COG5409	271..641	CDD:227696	110/397 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	129	1.000	Domainoid score	I1338
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I1076
OMA	1	1.010	-	-		QHG54286
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		otm47212
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
TreeFam	1	0.960	-	-
	11	10.930