DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10481 and Xpr1

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_035403.1	Gene:	Xpr1 / 19775	MGIID:	97932	Length:	695	Species:	Mus musculus

Alignment Length:	685	Identity:	259/685 - (37%)
Similarity:	375/685 - (54%)	Gaps:	65/685 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |||.:.|...:.||||.||:.|...|.|:.:|.::|||......|....|:..|||.||.:|..|
Mouse     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQLDRR-RAQQDPRGSTASRGSASSWSRQP------EGKRKF 123
            |.|:|.|::.|.|||.|:.|||..:|... ..|::..|.|..|     ..|:|      |.:.:.
Mouse    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSGVTTLR-----QRRKPVFHLSHEERVQH 125

  Fly   124 PPIKKLRLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQ 188
            ..||.|:||.||||||||:|||||.||.|.||||.||:||.|::..|..|...:|..:......:
Mouse   126 RNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKK 190

  Fly   189 LDRMISTTENMYTDYLANGDRSEAMAKLRVPPLG--HPTPPVHVFSAGLFLGLFLVSAI-LCFIS 250
            ::::||.||.:.|:.|.:|||.:||.:|||||||  .|.|....|..|||.|:|:|..| |.|.:
Mouse   191 INQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVFAA 255

  Fly   251 YFAVDTSPEFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEI 315
            .|.::|.... :..:.::||....:.|.|.|.||...:...|||.|||||:..||.:......||
Mouse   256 VFKLETDRTV-WPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEI 319

  Fly   316 SSFFGYMCTLSILLYLLHKEFFIEDPIYI-PLVQVAFVVVLFLNPFRILFYSGRIWLLTVMGRIL 379
            :.|.|.:..||:|.........|  |||: ||....|:|...:||.:..:|..|.|||.::.|:.
Mouse   320 AGFLGILWCLSLLACFFAPISII--PIYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVF 382

  Fly   380 LSPFFFVNFADFWVADQWTSLVVTIVDHYYLVRFYVRYFLDRSDAFEF--------------EPD 430
            .:||..|.|||||:|||..||.|.::|..|::.||         :||.              ||:
Mouse   383 TAPFHKVGFADFWLADQLNSLSVILMDLEYMICFY---------SFELKWDESKGLLPNDPQEPE 438

  Fly   431 ------YAV-AVIRCLPAWFRFAQSLRRFRDSGSKSTDYLINALKY----FLFIAEVVFSTIQME 484
                  |.| |:::|:|||.||.|.|||:||: .::..:|:||.||    |......::||.:.:
Mouse   439 FCHKYSYGVRAIVQCIPAWLRFIQCLRRYRDT-RRAFPHLVNAGKYSTTFFTVTFAALYSTHEEQ 502

  Fly   485 TIAHYTDLFESPWTWAYITICIVSSIYTVFWDLLMDFGLFRVWNGENKFLRDNLVYP-RWFYYFV 548
               :::|.....:.|.:  .||:||.||:.|||.||:|||....|||.|||:.:||| :.:||..
Mouse   503 ---NHSDTVVFFYLWVF--FCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCA 562

  Fly   549 IVENTLLRCVWILEFALVHQELIAPYNGK---SLICFSEIARRFFWNFLRLENEHLYNCGQFRAT 610
            |:|:.:||..|.::.::.  ....|:.|.   ::....|:.|||.|||.|||||||.|||:|||.
Mouse   563 IIEDVILRFAWTIQISIT--ATFKPHVGNIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAV 625

  Fly   611 RDIFITRLDPQEERFLESVMDNTEDLGREKLNKKY 645
            |||.:..|:..::..||.:||..:.:...:.|:.:
Mouse   626 RDISVAPLNADDQTLLEQMMDQEDGVRNRQKNRSW 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	72/167 (43%)
		SPX	3..163	CDD:281146	71/166 (43%)
		EXS	267..601	CDD:281164	131/363 (36%)
Xpr1	NP_035403.1	SPX_XPR1_like	2..165	CDD:269898	72/167 (43%)
		SPX	3..169	CDD:281146	74/170 (44%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	158..165		4/6 (67%)
		EXS	286..616	CDD:281164	126/348 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..695
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	1	1.010	-	-		QHG54286
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830