DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10481 and xpr1a

DIOPT Version :9

Sequence 1:	NP_995731.1	Gene:	CG10481 / 35273	FlyBaseID:	FBgn0032827	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001232029.1	Gene:	xpr1a / 100170805	ZFINID:	ZDB-GENE-060503-362	Length:	692	Species:	Danio rerio

Alignment Length:	680	Identity:	263/680 - (38%)
Similarity:	366/680 - (53%)	Gaps:	60/680 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFGKTLDNLMVPEWRYQYMNYNELKQMIRNAVEKAPSGSRPSNDVAIGYYRNFEELFFNSCRVE 65
            |||.:.|...:.||||.||:.|...|:|:..|.::|||......|....||..|||.||.:|..|
Zfish     1 MKFAEHLSAHITPEWRKQYIQYEAFKEMLYAAQDQAPSLEVTDEDTVKRYYAKFEEKFFQTCEKE 65

  Fly    66 LTKVNYFFAHKQAEAHRKLATLNYQ----LDRRRAQQDPRGSTASRGSASSWSRQPEGKRKFPPI 126
            |:|:|.|::.|.|||.|:.|||..:    ||.:|....| ...:.|.:....|.:...|.:  .|
Zfish    66 LSKINTFYSEKLAEAQRRFATLQNELQTSLDAQRESNAP-ALRSRRKTVLPLSNKERNKHR--NI 127

  Fly   127 KKLRLAMSEFYLSLIMLQNYQTLNMTAFRKICKKYDKNLKSEAGFAWYEKYVLKSTLAITLQLDR 191
            |.|:||.||||||||:|||||.||.|.||||.||:||.|.:..|..|...:|..:......::.:
Zfish   128 KDLQLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILDTPRGADWRVAHVEVAPFYTCKKITQ 192

  Fly   192 MISTTENMYTDYLANGDRSEAMAKLRVPPLG--HPTPPVHVFSAGLFLGLFLVSAILCFISYFAV 254
            :||.||.:.|..|..|||.:||.:|||||||  .|.|....|..||:.|:|:|.|: .|:...|.
Zfish   193 LISETEALVTTELEGGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGVFIVLAV-AFVLTGAF 256

  Fly   255 DTSPEFRYTFVSLFRGPISGVTFGFCLAINIKVYETVGVNQVLIFEVERRNAIGAMRALEISSFF 319
            ....:..:..|.::||....|.|.|.|.||...:...|||.|||||:..||.:......||:.|.
Zfish   257 FVRKQNIWPLVRIYRGGFLLVQFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFL 321

  Fly   320 GYMCTLSILLYLLHKEFFIEDPIYI-PLVQVAFVVVLFLNPFRILFYSGRIWLLTVMGRILLSPF 383
            |.:..||||..|.....::  |:.. ||:...|:::..:|||:..:|..|.||:.::.|:..:||
Zfish   322 GVLWCLSILSCLFADYTWL--PMQANPLILYGFMLLFLINPFKTAYYKSRFWLIKLLFRVFTAPF 384

  Fly   384 FFVNFADFWVADQWTSLVVTIVDHYYLVRFY--------------VRYFLDRSDAFEFEPDYAV- 433
            ..|.|||||:|||..|||:.:.|..|||.:|              .::..:|.::|    .|.|
Zfish   385 HRVEFADFWLADQLNSLVIVLSDLEYLVCYYSMELQWGERNGLLPAKFGDERCNSF----SYGVR 445

  Fly   434 AVIRCLPAWFRFAQSLRRFRDSGSKSTDYLINALKYFLFIAEVVFSTIQMETIAHYTDLFESPWT 498
            |:|.|||||.||.|.|||:||: .::..:|:||.||......|.|:.:..   .|..........
Zfish   446 AIIHCLPAWLRFVQCLRRYRDT-RRAFPHLVNAGKYSTTFFVVTFAALYR---THKDQNHADSEV 506

  Fly   499 WAYITI--CIVSSIYTVFWDLLMDFGLFRVWNGENKFLRDNLVYP-RWFYYFVIVENTLLRCVWI 560
            :.|:.:  .||||:||:.|||.||:|||....|||.|||:.:||| :.:||..|:|:.|||..|.
Zfish   507 FFYMLVLSSIVSSLYTLIWDLKMDWGLFDRNAGENTFLREEIVYPHKAYYYCAIIEDVLLRFAWT 571

  Fly   561 LEFALVHQ-----------ELIAPYNGKSLICFSEIARRFFWNFLRLENEHLYNCGQFRATRDIF 614
            |:.:|...           .::||.         |:.|||.|||.|||||||.|||:|||.|||.
Zfish   572 LQISLTSMTRIPSIEDIVVTILAPL---------EVFRRFVWNFFRLENEHLNNCGEFRAVRDIS 627

  Fly   615 ITRLDPQEERFLESVMDNTEDLGREKLNKK 644
            :..|:..::..||.:||. ||..|.:..||
Zfish   628 VAPLNADDQTLLEQMMDQ-EDGVRNRQGKK 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10481	NP_995731.1	SPX_XPR1_like	2..163	CDD:269898	72/164 (44%)
		SPX	3..163	CDD:281146	71/163 (44%)
		EXS	267..601	CDD:281164	133/363 (37%)
xpr1a	NP_001232029.1	SPX_XPR1_like	2..164	CDD:269898	72/164 (44%)
		SPX	3..169	CDD:281146	74/168 (44%)
		EXS	284..614	CDD:281164	127/348 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890