DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and ARHGAP9

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001306779.2	Gene:	ARHGAP9 / 64333	HGNCID:	14130	Length:	750	Species:	Homo sapiens

Alignment Length:	755	Identity:	175/755 - (23%)
Similarity:	277/755 - (36%)	Gaps:	197/755 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LHSHALASAEAGGIGGVNGGPIACHASTDKD------AQAPPLQFEMDAPAA-----AISAQLNF 66
            |::.....|:...:....|........|:.|      .:||.....:..|||     :|.:|...
Human    30 LYAFTYTGADGQQVSLAEGDRFLLLRKTNSDWWLARRLEAPSTSRPIFVPAAYMIEESIPSQSPT 94

  Fly    67 KIVPADSL--PGL-----SYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNS 124
            .::|...|  ||.     |.:::..::.:.  :.||:|.          |||.|          .
Human    95 TVIPGQLLWTPGPKLFHGSLEELSQALPSR--AQASSEQ----------PPPLP----------R 137

  Fly   125 KSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFI 189
            |.||....:..:....:..|.||....|    |:....|.||.|..|..|   |.|..|..|..:
Human   138 KMCRSVSTDNLSPSLLKPFQEGPSGRSL----SQEDLPSEASASTAGPQP---LMSEPPVYCNLV 195

  Fly   190 -IRVCPQRCEPF----LIKRSFENMQLLDEMLHRCVYDRKISGLRNME--------------ELA 235
             :|.||:...|.    |::|.....|.||....||.|...::|.::.:              |..
Human   196 DLRRCPRSPPPGPACPLLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETNPGSMEGT 260

  Fly   236 AELPSESDVEYAVAKYL-------ERFSKIASDSLTCGTILTWLQLDNKGRRLP-----LADG-- 286
            ..|...:||....||..       |......|.||:..|    .|||....:.|     |.|.
Human   261 QTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRT----SQLDPPALQAPRPLPQLLDDPH 321

  Fly   287 --ETQRTINTPAVGAAYGVRRYQAQ-APDEINIEVGDMISVIDMPSPAESIWW------------ 336
              |....:|...:  |.|.|:.:.. .|..:.:....::...:.|..|.|..|
Human   322 EVEKSGLLNMTKI--AQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVD 384

  Fly   337 -------RGKKSHLQKSLYEVGFFP------QS-----------CVATIGDKV------------ 365
                   .|:....::::..:...|      ||           .:.|:.:::
Human   385 LRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPT 449

  Fly   366 -------PRNFPM--------PAPLVGHLDASP-----TKPVLR--------------KHGKLIA 396
                   .|..|:        ||.|....|...     :||:||              :..::..
Human   450 GRDQGSGDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRN 514

  Fly   397 FFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRL 460
            ..:..|..||..:.|::.|:.|::||.|.|.......|..:|..||.|...::..|: :|||||:
Human   515 KLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRV 579

  Fly   461 SGITSNIQRLRRAFDEERVP------------------DLGNPEMKQDIHAVSSLLKMYFRELPN 507
            ||..:.:|:||...|.||..                  ||.:.|. .|||.|:..||::.||||.
Human   580 SGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW-DDIHVVTGALKLFLRELPQ 643

  Fly   508 PLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTD 572
            ||....|..:|..|:.:  .|:::.|..::|.:..:|.|::.||:||.|||.:|..|..:..||.
Human   644 PLVPPLLLPHFRAALAL--SESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTP 706

  Fly   573 KNLAIVWAPNLLRSPALESGGVAA---LRGVGVQAVVTEY 609
            .||.||:.|.|.| |..|:...||   ..|..||.::|.:
Human   707 HNLGIVFGPTLFR-PEQETSDPAAHALYPGQLVQLMLTNF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	31/131 (24%)
		SH3_ARHGAP32_33	299..358	CDD:212769	12/95 (13%)
		RhoGAP_CdGAP	420..613	CDD:239849	72/212 (34%)
		FliJ	1322..1457	CDD:304890
ARHGAP9	NP_001306779.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..187		22/95 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..319		16/80 (20%)
		Lipid binding	342..345		0/2 (0%)
		Lipid binding	397..399		0/1 (0%)
		Lipid binding	432..669		60/239 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..488		6/41 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940