DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Arhgap23

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_006533928.1	Gene:	Arhgap23 / 58996	MGIID:	3697726	Length:	1489	Species:	Mus musculus

Alignment Length:	1215	Identity:	248/1215 - (20%)
Similarity:	401/1215 - (33%)	Gaps:	407/1215 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KVSTSLAAQLH-SHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFK 67
            ||..:.|.|:: .....|.|....|...|..:|..|:|:....:.|...|..:|    |..|..|
Mouse   503 KVQLTPARQMNLGFGDESPEPEARGERLGRKVAPLATTEDSLASIPFIDEPTSP----SIDLQAK 563

  Fly    68 IVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKL 132
            .|||.::       :.::||::.:...|..   ||....|:     |||.:
Mouse   564 HVPASAV-------VSSAMNSAPVLGTSPS---SPTFTFAL-----SRHYS-------------- 599

  Fly   133 EECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRC 197
            ::|:     .::.|..|..||...:|...|.           ...|.:|..|.  .::|..|.|.
Mouse   600 QDCS-----SIKAGRRSSYLLAITTERSKSC-----------DDGLNTFRDEG--RVLRRLPSRV 646

  Fly   198 EPFLIKRSFENMQLLDEM-------------------------LHR--CVYDRKI---------S 226
            ....:.|||.....||..                         :.|  .:|.::|         .
Mouse   647 PSLRVLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGG 711

  Fly   227 GLRNMEELAAELPSES-------------------------------------DVEYAVAKYLER 254
            |||..:.:.|.|.:.|                                     |:.|:..|....
Mouse   712 GLRQWKRVYAVLRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHV 776

  Fly   255 FSKIASDSLTC---------GTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQA 310
            |....:|  .|         ..:|.|::...:..|   |:||.....|...:.......|
Mouse   777 FRLTTAD--FCEYLFQAEDRDDMLGWIRAIRENSR---AEGEDPGCANQALISKKLNDYR----- 831

  Fly   311 PDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPL 375
              :::...|....    .||..|....|.||.         |..|:.|..:     |....|...
Mouse   832 --KVSHSSGPKAD----SSPKGSRGLGGLKSE---------FLKQTAVRGL-----RTQEQPPGS 876

  Fly   376 VGHLDASPTKP----VLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQD 436
            .....|:|..|    :::|:.|  |..|:|             ||   |:..|..:    ...|.
Mouse   877 KEDSVAAPKTPWGINIIKKNKK--AAPRAF-------------GI---RLEECQPA----TENQR 919

  Fly   437 IPMVLRSCAEFIENYGV-IDGIYRLSG---ITSNIQ-RLRRAFDEERVPDLGNPEMKQDIHAVSS 496
            :|:::.:|...:|..|: ..||||:.|   :.|::| :|.|...:..:.|    |..||::.:||
Mouse   920 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPSDINLQD----ERWQDLNVISS 980

  Fly   497 LLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKV 561
            |||.:||:||.||.|...|::|:||.::  :::.||::.:::.:..||..:|.|||:|..||..:
Mouse   981 LLKAFFRKLPEPLFTDDKYNDFIEANRI--EDSRERMKTLRKLIRDLPGHYYETLKFLVGHLKTI 1043

  Fly   562 SQHHGRTGMTDKNLAIVWAPNLLR-------------------------------SPALESGGVA 595
            :.|..:..|..:|||:|:.|.|:|                               |...:.|...
Mouse  1044 ADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDEDKGERT 1108

  Fly   596 ALRGVGVQAVVT-EYLIRNCHNIFDALD---------------------DHPARHSMVASATAAA 638
            .:.....|:|.. |||:.|........|                     ..|....|:|.:..:|
Mouse  1109 PVDDKEPQSVPNIEYLLPNIGRTVPPSDPGSADSTTCSSAKSKGSWVPKKEPYAREMLAISFISA 1173

  Fly   639 ANAAGGELR----LESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEG 699
            .|....:.|    |.|.||.:|   ||.....::|..|.|:....|.|    .|||..|
Mouse  1174 VNRKRKKRREARGLGSSTDDDS---EQEAHKAAVGTQEPPEGQLPGPA----AEEAPGR------ 1225

  Fly   700 ADLKQSLPISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIF 764
                    :|..|:.....|::..|.:   .|.|:|.....:|.|.....:....|:....:|..
Mouse  1226 --------LSPPTAPDERPAADTRSIV---SGYSTLSTMDRSVCSGTGGRRAGAGDEADDERSEL 1279

  Fly   765 S--RSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPK 827
            |  .:..:|...||.::        :.|.||  :|| |.                         .
Mouse  1280 SHVETDTEGGAGPGGRL--------SRRPSF--SSH-HL-------------------------M 1308

  Fly   828 PMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIF 892
            |.|...|       |.:..||:.:        :.|..|....||.          ..|.|.....
Mouse  1309 PCDTLAR-------RRLSRSRAEA--------EGPGAGTARACPR----------GPEPPGSASS 1348

  Fly   893 SESESL---VSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSAR 954
            |..|||   .::|.:|..   |:...|.|..:|...:|                   :|:....|
Mouse  1349 SSQESLRPPAAAPALGSR---PSRVEALRLRLRGTADD-------------------MLAVRLRR 1391

  Fly   955 TMPPPPLSAPGTASSSCGHESGGAENCCKRYK--LEDQLCDIQF-----IDCGTPENVPTTQQQF 1012
            .:.|               |:....:..:|:.  ::..|.|:.|     :..|.|       |:.
Mouse  1392 PLSP---------------ETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGP-------QES 1434

  Fly  1013 ASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGA 1057
            ..|..|...|     .|.:||.......:||::   |.||..|||
Mouse  1435 VGVRPHSDNK-----DSGLSSLESTKARASSAA---SLPSGDLGA 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	28/187 (15%)
		SH3_ARHGAP32_33	299..358	CDD:212769	10/58 (17%)
		RhoGAP_CdGAP	420..613	CDD:239849	63/229 (28%)
		FliJ	1322..1457	CDD:304890
Arhgap23	XP_006533928.1	PDZ_signaling	41..156	CDD:238492
		PHA03247	<176..578	CDD:223021	22/85 (26%)
		PH_ARHGAP21-like	691..811	CDD:269955	18/124 (15%)
		RhoGAP_ARHGAP21	903..1098	CDD:239860	59/220 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940