DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and ARHGAP23

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001186346.1	Gene:	ARHGAP23 / 57636	HGNCID:	29293	Length:	1491	Species:	Homo sapiens

Alignment Length:	1177	Identity:	245/1177 - (20%)
Similarity:	393/1177 - (33%)	Gaps:	384/1177 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASM 86
            ||.|.|...|..:|..|:|:....:.|...|..:|    |..|..|.|||.::       :.::|
Human   521 EASGRGERLGRKVAPLATTEDSLASIPFIDEPTSP----SIDLQAKHVPASAV-------VSSAM 574

  Fly    87 NTSQISNASTESSCSPPIQGAVPPPKPS------RHMAVQPLNSKSCRFPKLEECAHFHYERVQL 145
            |             |.|:.| ..|..|:      ||.:              ::|:     .::.
Human   575 N-------------SAPVLG-TSPSSPTFTFTLGRHYS--------------QDCS-----SIKA 606

  Fly   146 GPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQ 210
            |..|..||...:|...|.           ...|.:|..|.  .::|..|.|.....:.|||....
Human   607 GRRSSYLLAITTERSKSC-----------DDGLNTFRDEG--RVLRRLPNRIPSLRMLRSFFTDG 658

  Fly   211 LLDEM-------------------------LHR--CVYDRKI---------SGLRNMEELAAELP 239
            .||..                         :.|  .:|.::|         ||||..:.:.|.|.
Human   659 SLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALR 723

  Fly   240 SES-------------------------------------DVEYAVAKYLERFSKIASDSLTC-- 265
            :.|                                     |:.|:..|....|....:|  .|
Human   724 ARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTAD--FCEY 786

  Fly   266 -------GTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMIS 323
                   ..:|.|::...:..|   |:||.....|...:.......|       :::...|....
Human   787 LFQAEDRDDMLGWIRAIRENSR---AEGEDPGCANQALISKKLNDYR-------KVSHSSGPKAD 841

  Fly   324 VIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKP-- 386
                .||..|....|.||.         |..||....:     |...:||.......|:|..|
Human   842 ----SSPKGSRGLGGLKSE---------FLKQSAARGL-----RTQDLPAGSKDDSAAAPKTPWG 888

  Fly   387 --VLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIE 449
              :::|:.|  |..|:|             |:   |:..|..:    ...|.:|:::.:|...:|
Human   889 INIIKKNKK--AAPRAF-------------GV---RLEECQPA----TENQRVPLIVAACCRIVE 931

  Fly   450 NYGV-IDGIYRLSG---ITSNIQ-RLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPL 509
            ..|: ..||||:.|   :.|::| :|.|...:..:.|    |..||::.:|||||.:||:||.||
Human   932 ARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQD----ERWQDLNVISSLLKSFFRKLPEPL 992

  Fly   510 CTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKN 574
            .|...|::|:||.::  ::|.||:|.:::.:..||..:|.|||:|..||..::.|..:..|..:|
Human   993 FTDDKYNDFIEANRI--EDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRN 1055

  Fly   575 LAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAA 639
            ||:|:.|.|:|:..                          .|:.|.:...|.|:.:|.:
Human  1056 LALVFGPTLVRTSE--------------------------DNMTDMVTHMPDRYKIVET------ 1088

  Fly   640 NAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQ 704
                              |::..:.                   ..|.||.:...:.| |....|
Human  1089 ------------------LIQHSDW-------------------FFSDEEDKGERTPV-GDKEPQ 1115

  Fly   705 SLP-ISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTP--------SW 760
            ::| |..|       ..|||..:     |...|....|..|:.:|.....|.|.|        |:
Human  1116 AVPNIEYL-------LPNIGRTV-----PPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISF 1168

  Fly   761 KSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERD 825
            .|..:|.:::.....|...:|| .||         ...||         ||.:......| .||.
Human  1169 ISAVNRKRKKRREARGLGSSTD-DDS---------EQEAH---------KPGAGATAPGT-QERP 1213

  Fly   826 PKPMDLCIRSNSIDSL--------RTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNF 882
            ..|:...:...:...|        |....:||:.  |.:..|.:..|...:....|. :..|...
Human  1214 QGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIV--SGYSTLSTMDRSVCSGASGRR-AGAGDEA 1275

  Fly   883 DREEPEM-RIFSESES---------LVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNP 937
            |.|..|: .:.:::|.         |...|.....::.|....|.||:.|.||:  ........|
Human  1276 DDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPD--GEGAGRGGP 1338

  Fly   938 SPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTP 1002
            ...:.|  ...|.||..::.||   |...||.....|:       .|.:|.....|:..:....|
Human  1339 RAPEPP--GSASSSSQESLRPP---AAALASRPSRMEA-------LRLRLRGTADDMLAVRLRRP 1391

  Fly  1003 ENVPTTQQQFASVEVHP----------------------PPKPARANQSPISSSNGASVGSSSSS 1045
            .: |.|:::.:|...|.                      ||:||.|.   ..|.|..|..||..|
Human  1392 LS-PETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGAR---AHSDNKDSGLSSLES 1452

  Fly  1046 TRYSYPS 1052
            |:...||
Human  1453 TKARAPS 1459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	29/187 (16%)
		SH3_ARHGAP32_33	299..358	CDD:212769	11/58 (19%)
		RhoGAP_CdGAP	420..613	CDD:239849	58/197 (29%)
		FliJ	1322..1457	CDD:304890
ARHGAP23	NP_001186346.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..34
		PDZ_signaling	41..151	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..280
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..407
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..530		4/8 (50%)
		PH	689..808	CDD:278594	18/120 (15%)
		PH_ARHGAP21-like	690..810	CDD:269955	19/124 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..851		4/23 (17%)
		RhoGAP_ARHGAP21	902..1097	CDD:239860	66/289 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1155		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1175..1367		45/221 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1491		14/43 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940