DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and ARHGAP31

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_065805.2	Gene:	ARHGAP31 / 57514	HGNCID:	29216	Length:	1444	Species:	Homo sapiens

Alignment Length:	1679	Identity:	381/1679 - (22%)
Similarity:	603/1679 - (35%)	Gaps:	550/1679 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 SRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQ 468
            ::.::::||:.|  ....|.|||:|:|.:||||:|.||:|||||||.:|::||||||||:|||||
Human     3 NKGAKQKLKRKG--AASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQ 65

  Fly   469 RLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERL 533
            |||:.|..::.|||......||||.|.||.|:|||||||||.||:||:.|.||:....:|.  :|
Human    66 RLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEG--QL 128

  Fly   534 RLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALES---GGVA 595
            ..::..:.:|||.|||||:||..||..::....:|.|..:|||:|||||||||..:|:   .|.|
Human   129 ARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDA 193

  Fly   596 ALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVE 660
            |...|.||.||.|:::.:...||:                    |.|.|.|
Human   194 AFLAVRVQQVVIEFILNHVDQIFN--------------------NGAPGSL-------------- 224

  Fly   661 QREQDQSLGVVERP--KSLSTGG----AKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAA 719
              |.|::     ||  |||:...    .||:||||||.|               |:.|:..:...
Human   225 --ENDEN-----RPIMKSLTLPALSLPMKLVSLEEAQAR---------------SLATNHPARKE 267

  Fly   720 SNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRK-PDKTPSWKSIFSRSQRQGNPDPGQKITTDV 783
            ....|..|:.....:|   :||||..|.:  ||| ..|:..|||||:.. |.|         :|.
Human   268 RRENSLPEIVPPMGTL---FHTVLELPDN--KRKLSSKSKKWKSIFNLG-RSG---------SDS 317

  Fly   784 KDSVASRVS-FVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMD-LCIRSNSIDSLRTVGH 846
            |..::...| ||:.......|                 :..|..|.|| ||  |..::...|.|:
Human   318 KSKLSRNGSVFVRGQRLSVEK-----------------ATIRPAKSMDSLC--SVPVEGKETKGN 363

  Fly   847 -SRSVSHDSYFDLLQSPQRGHMTTCPSRELSELG----LNFDREEPEMRIFSESESLVSSPRVGK 906
             :|:|:...:|             .|:.::...|    .:..::|.|.               |:
Human   364 FNRTVTTGGFF-------------IPATKMHSTGTGSSCDLTKQEGEW---------------GQ 400

  Fly   907 ENVPP-ASG----SATRRIM---RARP-----------ED------------------------- 927
            |.:|| |.|    |:.|..:   :|||           ||
Human   401 EGMPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSV 465

  Fly   928 FSSQTNSVNPSPKKQPR-LNLLSP-----------------SSARTMPPPPLSAPGTAS--SSCG 972
            |:|....:.|||:.|.: ||:..|                 :..|| ||..|.:..:..  |..|
Human   466 FTSSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPCRT-PPKELQSLSSLEEFSFHG 529

  Fly   973 HESGG-------------AENCCKRYKLEDQLCDIQ---FIDCG---------------TPENVP 1006
            .||||             |.:..|:..|||.....:   .::|.               |||: .
Human   530 SESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPES-S 593

  Fly  1007 TTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSY 1071
            .:.|....:|..|.|:..        ...|...|...|||....|..:..|....:.|..:   .
Human   594 LSSQHLNELEKRPNPEKV--------VEEGREAGEMESSTLQESPRARAEAVLLHEMDEDD---L 647

  Fly  1072 QGTFTQPGQKQE----------SSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSP 1126
            ......|..:||          ||.|.|        .|:...::|:.:..:...:|: ..|...|
Human   648 ANALIWPEIQQELKIIESEEELSSLPPP--------ALKTSPIQPILESSLGPFIPS-EPPGSLP 703

  Fly  1127 RYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHE 1191
            ..|.          .:.|:||   :|......|.....|.|:                  .:|.|
Human   704 CGSF----------PAPVSTP---LEVWTRDPANQSTQGAST------------------AASRE 737

  Fly  1192 SLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNS 1256
            ........|.|        |.....|::.|.:...||     ||:.|            ..|.|.
Human   738 KPEPEQGLHPD--------LASLAPLEIVPFEKASPQ-----ATVEV------------GGPGNL 777

  Fly  1257 NFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKST--ISITYK 1319
                                              |.|:      .|....|:|::.:  :.::..
Human   778 ----------------------------------SPPL------PPAPPPPTPLEESTPVLLSKG 802

  Fly  1320 SPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLH-----ERSSLKQIAEEEQHDGGAYK 1379
            .||:|.. |..|.|:.    ..:|:|  .....|::.:..     .|.|.||.::....:|....
Human   803 GPEREDS-SRKLRTDL----YIDQLK--SQDSPEISSLCQGEEATPRHSDKQNSKNAASEGKGCG 860

  Fly  1380 AAEMTQQLLQLEQEHHD--HEEQQEKE-PEDEEQSQLLYENIEL----RKPKTVYENLRGEEMKF 1437
            ....|:::..:.||..|  |..|:..: .||:..:.:....:|:    .:|:.|...|....:|.
Human   861 FPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQHGLEMVEPWEEPQWVTSPLHSPTLKD 925

  Fly  1438 ITEEQKPNVDRIELD-------------SLDSLPD----------------NMEHEQSSPSKSPT 1473
            ..:.|...:...:|:             ||||.|.                |:|.|::|....|.
Human   926 AHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPTVKSQWTLEVPSSSSCANLETERNSDPLQPQ 990

  Fly  1474 FSVKELANKFESSPVEQLPNF-DFSVRGGSMKKPNELSVPKTMPAPVPLKKLN-SSAQKITRSLD 1536
            ...:|:....|.:    |.:| :||...|:...||:.......|.|.....:: :..:::...|.
Human   991 APRREITGWDEKA----LRSFREFSGLKGAEAPPNQKGPSGVQPNPAETSPISLAEGKELGTHLG 1051

  Fly  1537 ENA-FVREFG----------GKQLQDLSLSNKLPEVMSEVNSRRKSFDFTRPKTLNPPKRL---- 1586
            .:: .:|:.|          ...:||.:...:.|..:     :.||.:...||..|.|..|
Human  1052 HSSPQIRQGGVPGPESSKESSPSVQDSTSPGEHPAKL-----QLKSTECGPPKGKNRPSSLNLDP 1111

  Fly  1587 ------------------PGMSITE-------------------EICQKRVGEMEAITPTTENR- 1613
                              |||.::|                   .:..:...:::.:......|
Human  1112 AIPIADLFWFENVASFSSPGMQVSEPGDPKVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRR 1176

  Fly  1614 ------ISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIK--------------E 1658
                  :|.::.:.|.|..|:.|...:||                  ||:              |
Human  1177 NSAPVSVSAVRTSFMVKMCQARAVPVIPP------------------KIQYTQIPQPLPSQSSGE 1223

  Fly  1659 ERRQQLTQKYYGDTLKSRSRTELNSEDNFPAAESLRIKSKSRGDMHALQKD-IDMNLKQLSRVTG 1722
            ...|.|.:...|.:..| ..|:..::|:.|::.....:.|.:.|..|::.. :|.....:
Human  1224 NGVQPLERSQEGPSSTS-GTTQKPAKDDSPSSLESSKEEKPKQDPGAIKSSPVDATAPCM----- 1282

  Fly  1723 GGSECTLHTGLSQGNGQEHLGQQRVRRISDEKNQNCDTSNGGVSGITSTSLLSVKTTAQKYGSTS 1787
                |...| ||...|..:|...:...:...|..: :|...|      .:|||.|......||
Human  1283 ----CEGPT-LSPEPGSSNLLSTQDAVVQCRKRMS-ETEPSG------DNLLSSKLERPSGGS-- 1333

  Fly  1788 KTPANKFERSQP-MPRDRLQ-------RNSLAESNAGTNNREKISPQFSIRDVT 1833
                ..|.||:| .|:..:.       .:.|..|:..|:::..:||   ||..|
Human  1334 ----KPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSP---IRSPT 1380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769
		RhoGAP_CdGAP	420..613	CDD:239849	103/195 (53%)
		FliJ	1322..1457	CDD:304890	31/159 (19%)
ARHGAP31	NP_065805.2	RhoGAP_CdGAP	17..211	CDD:239849	103/195 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..427		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..631		29/136 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..893		52/308 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..1108		39/210 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1211..1346		32/158 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146172
Domainoid	1	1.000	194	1.000	Domainoid score	I3172
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.830