DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and bcr

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_002665983.2	Gene:	bcr / 568320	ZFINID:	ZDB-GENE-040724-43	Length:	1341	Species:	Danio rerio

Alignment Length:	524	Identity:	130/524 - (24%)
Similarity:	205/524 - (39%)	Gaps:	93/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLL 153
            |.::..:.|.|...||     |..|...:....:...|.|.....|      .|...|...::.|
Zfish   831 SDLTFQTAEESEPLPI-----PQAPDEELDAIKIKISSLRSEIQRE------RRANKGSKVMERL 884

  Fly   154 DDKSEHMGSSIASQSLGGDLPHSSLR--SFSPESCWFIIRVCPQRCEPFLI-----KRSFENMQL 211
            ..|.....|.....|     |:..||  :.:.:|..|:|....:|.|...:     |:.|:...|
Zfish   885 KKKLSEQESLFLLNS-----PNMPLRVHNRNGKSYMFLISSDYERAEWKEVIREQQKKCFKTFNL 944

  Fly   212 ----LDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWL 272
                |..:.:.||      .|:.:.:|...:..|.|....:..:|......||.......:...|
Zfish   945 SSMELQMLTNSCV------KLQTVHQLPLTVNKEEDESTGLYGFLNVIVHSASGLKQSLNLYCTL 1003

  Fly   273 QLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWR 337
            ::|:.|..:..|.....|....|             :..:|..||:
Zfish  1004 EVDSFGIFVNKAKTRVYRYTTEP-------------KWNEEFEIEL------------------- 1036

  Fly   338 GKKSHLQKSL-YEVGFFPQSCVATIGDKVPR-----NFPMPAPLVGHLDASPTKPVLRKHG---K 393
             :.||..:.| ||..:.........|:...|     ..|:...::...|...|  |:..:|   |
Zfish  1037 -EGSHTLRLLCYEKSYNKAKVNKEDGESTDRIMGKGQMPLDPQMLQGKDWQRT--VIPMNGIEVK 1098

  Fly   394 LIAFF--RSFILSR-PSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVID 455
            :...|  |.|.|.| |||:.:        .||..::|.........:|.::|.|.|.||..|:.:
Zfish  1099 ISMKFTSREFSLKRMPSRKPM--------GVFGVNISTVTKRERSKVPYIVRQCLEEIERRGMEE 1155

  Fly   456 -GIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFV 519
             ||||:||:.::||.|:.|||... .|:.....:.|::|::..||:||||||.||.|.:||.||.
Zfish  1156 VGIYRVSGVATDIQALKTAFDTNN-KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDELYPNFA 1219

  Fly   520 EAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLL 584
            ..|.:....|.|  ..|...:|.||.|:..|..:|.:||.::::......|:..|||.|:.|.||
Zfish  1220 GGIALSDSVAKE--SCMLNLLLSLPEPNLVTFLFLLDHLKRIAEKECVNKMSLHNLATVFGPTLL 1282

  Fly   585 RSPA 588
            | ||
Zfish  1283 R-PA 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	23/116 (20%)
		SH3_ARHGAP32_33	299..358	CDD:212769	8/59 (14%)
		RhoGAP_CdGAP	420..613	CDD:239849	63/170 (37%)
		FliJ	1322..1457	CDD:304890
bcr	XP_002665983.2	Bcr-Abl_Oligo	3..75	CDD:286168
		RhoGEF	573..761	CDD:279015
		PH-like	755..947	CDD:302622	27/131 (21%)
		C2_ABR	983..1103	CDD:176068	25/154 (16%)
		RhoGAP_Bcr	1122..1322	CDD:239852	62/168 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940