Protein Alignment CdGAPr and arhgap32a

DIOPT Version :9

• Sequence 1: NP_001260600.1
• Gene: CdGAPr / 35267
• FlyBaseID: FBgn0032821
• Length: 1843
• Species: Drosophila melanogaster
• Sequence 2: XP_690921.4
• Gene: arhgap32a / 562449
• ZFINID: ZDB-GENE-060503-918
• Length: 1676
• Species: Danio rerio
• Alignment Length: 1943
• Identity: 512/1943 - (26%)
• Similarity: 791/1943 - (40%)
• Gaps: 483/1943 - (24%)

  Fly    38 ASTDKDAQAPPLQFEMDAPAAA-----ISAQLNFKIVPADSLPGLSYQDMFASM--NTSQISNAS 95
            |:|:..|..||.......|:..     ...:.:..:.||::   ..::|..|.|  ....:....
Zfish     9 AATNARASTPPTDASTHDPSEGPHPEEDEGEEDRSLQPAET---AGWEDAIAVMARGAPTVPELP 70

  Fly    96 TESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHM 160
            .|||....:..|....|     .|:.|:.....||||.||||||||.|..|.:.:.|.|:::
Zfish    71 AESSLRSCVSTASMKVK-----NVKKLSLTKRHFPKLAECAHFHYENVDFGSVQLSLTDEQN--- 127

  Fly   161 GSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKI 225
                       ||.::.|.  |.||. ::|::|.|. ..:.::||:|..::||:.||.|:|||:.
Zfish   128 -----------DLTNNGLD--SKESV-YLIQICCQG-RKWTVRRSYEEFRVLDKHLHLCIYDRRF 177

  Fly   226 SGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQR 290
            |.|..:..:.:.......:...:..|:.|.|.||.:.:.||..|||:::||||..|.:.|   :.
Zfish   178 SQLPELPRIDSLKDKTGTLSQMLTAYISRLSAIADNKINCGPALTWMEIDNKGNHLLVND---ES 239

  Fly   291 TINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQ 355
            :||.|||.||:.::||.|||.||::.||||::||||||...::.|||||..      ::|||||.
Zfish   240 SINVPAVAAAHVIKRYIAQAADELSFEVGDIVSVIDMPPKEDTGWWRGKHG------FQVGFFPS 298

  Fly   356 SCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRER 420
            .||..|.:|:|.|          :.:|..|||.:||||||.|.|:|:.|||::::|||.||.:||
Zfish   299 ECVELISEKIPSN----------VTSSLAKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKER 353

  Fly   421 VFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNP 485
            ||.|||.|||||||.|:|.|:|||.||||.:||:|||||||||:||||:||..||.|.||||...
Zfish   354 VFGCDLGEHLLNSGHDVPQVIRSCTEFIERHGVVDGIYRLSGISSNIQKLRHEFDSEHVPDLTKD 418

  Fly   486 EMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRT 550
            ...||||:|.||.|:|||||||||.|||||:.|.:|:....|  ||||..:.:.:.:||||||||
Zfish   419 TYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATD--DERLVKVHDVIQQLPPPHYRT 481

  Fly   551 LKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALES---GGVAALRGVGVQAVVTEYLIR 612
            |::|..||.::..:...|.|..||||||||||||||..:||   .|.:|...|.||:||.|:::.
Zfish   482 LEFLMRHLSRMGTYSNVTNMHCKNLAIVWAPNLLRSKQIESACFSGTSAFMEVRVQSVVVEFILN 546

  Fly   613 NCHNIF----DALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVER 673
            :...:|    ..|..|...|:.:|                                        |
Zfish   547 HVDVLFSPKLSTLIRHSTGHTTLA----------------------------------------R 571

  Fly   674 PKSL--STGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNA-ASNIGSYIEVGGGPSSL 735
            ||||  |:...||:||||||.|                  |.|..|: .|....||:||.||::|
Zfish   572 PKSLLVSSPSTKLLSLEEAQAR------------------TQAQLNSPVSPDSKYIDVGEGPAAL 618

  Fly   736 PDKYHTVLSAPRSWQK--RKPDKTP--SWKSIFSRSQRQGN------------------PDPGQK 778
            ..|:|||:..|...:|  .|..|:|  :|.|.|:..:...:                  |.||.:
Zfish   619 QGKFHTVIDFPSERKKGSTKGKKSPVGNWLSFFNMGKSSASAKPKLHRHPSEPNDMKTTPLPGGR 683

  Fly   779 ITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSI-ELLETTSNERDPKPMDLCIRSNSIDSLR 842
            ..|....|..|..|...:.:......:.:..:|.|. :.|..:.||   :.:|..:..:|..||:
Zfish   684 GDTGTLRSAKSEESLSSSHNFEGGSNIYRPRRPLSTSDALSLSFNE---ELLDSRLTGDSRSSLK 745

  Fly   843 TVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELG---LNFD---------------REEPEM 889
              .|.:..|..|....|.||..      ||.:...:|   |:.|               ::....
Zfish   746 --DHRKDTSSSSCVPALISPPH------PSADAEFIGISSLDIDPLAFQSARLVEQENKKKGSRK 802

  Fly   890 RIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFS----------SQTNSVNPSPKKQPR 944
            :...::..|..|.:|...:.||..........:.||.:..          |:|..:..|....|:
Zfish   803 KAGGKNHELEPSNKVTSPSQPPDLIPLRAEDSKHRPSELPLSSTNLDVGFSKTGQMGTSRSSVPK 867

  Fly   945 LNLLS-PSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTT 1008
            .:.:| ||...::...|     :.|...|.....:.:.||                        |
Zfish   868 SSTVSCPSDIVSLMKKP-----SVSMKAGEGHQRSASFCK------------------------T 903

  Fly  1009 QQQFASVEVHPPPKPARANQSPIS-SSNGASVGSSSSSTRYSYPSVQLGAKR-----KEQQDAKE 1067
            :.:.|.|:.|     .||:...:: ......|.|.|..|  ..|:|:..|:.     .|......
Zfish   904 ESKSADVKQH-----RRADSGAVTFECTPGLVRSVSLIT--PQPAVKSAARMLALALAESAQQAT 961

  Fly  1068 RFSYQGTFTQPGQKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLL 1132
            |.|.:|:...|      :...|:|..|...||:.|             .|..|:..|..||:
Zfish   962 RLSKRGSSEPP------TPISPIHHKNPLFTLQFP-------------PPVQTSSDREERYA--- 1004

  Fly  1133 CDTESSDNSSAVNTPQY-DMEPLMLTSAM----SGVS----------GVSSNVQQQQLLLGVDAS 1182
            .:....|.||.::|..: |...|..|.|.    ||:|          |..::|..|......|..
Zfish  1005 SNRAFPDPSSTMSTESHTDAGSLRSTCACHGSESGLSFSDGCDAPAGGQCTHVPSQGFSPRTDPE 1069

  Fly  1183 SSYLGSSHESLGQNI----------NNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLP 1237
            ...:..:..:|..||          .:..|||.....:|:..||...:.|        :..:.:.
Zfish  1070 IQLVQETQTTLRDNIRHVGVGTDGGGSSLDAEMEVRGSLQTTLSERYSSL--------DSPSAID 1126

  Fly  1238 VKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTP 1302
            .....|||.||        ||....:::..|:           |:..:|....|:|.
Zfish  1127 ALHNKQAANAA--------NFRAILAETAMPA-----------SVQEVLPQASSTPP-------- 1164

  Fly  1303 VKMVPSPIKSTISITYKSPEKEKKP-----SAILETNFDENTVYEQVKLFRNSVTEVNQMLHERS 1362
                        |:.|:...:|::.     |....::..::|.|.||...|     .:..:..||
Zfish  1165 ------------SVLYQYKPREQRSAYSQHSQQWSSSDGQSTSYYQVDDGR-----PHPRVLSRS 1212

  Fly  1363 SLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYENIELRK---PK 1424
            ....:|....|....||.                       :.||       |.::.:.:   |:
Zfish  1213 YCNTLAPRSLHQSIKYKG-----------------------QRED-------YSSVGVYRHGGPR 1247

  Fly  1425 TVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDN------MEHEQSSPSKSPTFS-VKELANK 1482
              |..|.|..:       .|.:.|:.  |:.:.|::      .:..||.|.::|..| ::.:...
Zfish  1248 --YPPLDGASV-------YPTIRRVR--SMHTPPEDKFFFLQRQGSQSKPYQNPPPSDIQHVRPY 1301

  Fly  1483 FESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMPAPVPLKKLNSSAQKITRSLDENAFVREFGGK 1547
            ||...|....:.....|....::.:..::..|      |.||.|.:.|: .:..||..      |
Zfish  1302 FEDGKVRYRYSPYSEARYNQYRENSGYTLSYT------LNKLPSRSSKV-MATSENYH------K 1353

  Fly  1548 QLQDLSLSNKLPEVMSEVNSRRKSFDF-TRPKTLNPPKRLPGMSITEEICQKRVGEMEAITPTTE 1611
            .|::|.|:|:              .|| ||.....|.|:.|..             .||......
Zfish  1354 PLRNLPLNNE--------------SDFMTRDAGFLPRKKNPSF-------------YEAFNSGLS 1391

  Fly  1612 NR--ISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLK 1674
            :|  ...|:|.|..||:.                .|.|:.:..:  ::.:|:.|       :|:.
Zfish  1392 DRHFSQSIRQENAAKERP----------------LGPVVAQPHL--VRCDRQCQ-------ETMH 1431

  Fly  1675 SRSRTELNSE---DNFPAAESLRIKSKSR-GDMHAL-QKDIDMNLKQLSRVTGGGSECTLHTGLS 1734
            :|||:....|   ....|....|:...|. ...|.| :.|:.:..|.....:|.|::..|.  :.
Zfish  1432 TRSRSNSGKEMLISTEGADGKYRVTMVSHYSPEHPLSEPDMPVPSKSDRHDSGQGAKSALI--MK 1494

  Fly  1735 QGNGQEHLGQQRV------RRISDEKNQNC-DTSNGGVS---GIT--STSLLSVKTTAQKYGSTS 1787
            |.....:..|.|:      ..::..|..:| |..:.|.|   |:|  :...|..||.:
Zfish  1495 QSRSMHNYPQHRLESTALPHNLTLHKEYSCPDFKHTGSSDSFGVTHRNQDRLIYKTLS------- 1552

  Fly  1788 KTPANKFERSQPMPRDRLQRNSLAES--NAGTNNREKISPQFSIRDVTAMFESRSQNQ 1843
             .|...::..|.|.|:. ||:..::|  |.....:.|::.:   ||....|.|.|:.:
Zfish  1553 -NPKEDYQYIQAMSREP-QRSKRSQSVKNRNPPGQAKMTLE---RDHRLPFSSHSRTR 1605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	32/105 (30%)
		SH3_ARHGAP32_33	299..358	CDD:212769	29/58 (50%)
		RhoGAP_CdGAP	420..613	CDD:239849	114/195 (58%)
		FliJ	1322..1457	CDD:304890	23/142 (16%)
arhgap32a	XP_690921.4	PX_domain	112..226	CDD:295365	36/131 (27%)
		SH3_ARHGAP32_33	248..301	CDD:212769	29/58 (50%)
		RhoGAP_CdGAP	353..547	CDD:239849	114/195 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579738
Domainoid	1	1.000	185	1.000	Domainoid score	I3308
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1355
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		otm24519
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.820