DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and ARHGAP15

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_060930.3	Gene:	ARHGAP15 / 55843	HGNCID:	21030	Length:	475	Species:	Homo sapiens

Alignment Length:	411	Identity:	110/411 - (26%)
Similarity:	189/411 - (45%)	Gaps:	66/411 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 LTWLQLDNKG--RRLPLADGETQRTINTPAVGAAYGVRR---YQAQAPDEI-NIEVGDMISVIDM 327
            |..|.::.:|  ::..:|||..:...|..........||   |:......: |::.|.....:|:
Human    75 LEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDL 139

  Fly   328 PSPAESIWWRGKKSHLQKSLYEV------GFFPQS-----------CVATIGDKVPRNFPMPA-- 373
              ....|.|..:||. :|:::::      .|..||           .:....|::|::...|:
Human   140 --CGAHIEWAKEKSS-RKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRN 201

  Fly   374 ------------PLVGHLDASPTKPVLRKHGKLIAF------------------FRSFILSRPSR 408
                        .|:.|.| |..|....:|.|.:.|                  .:.||..|||.
Human   202 LELFKIQRSSSTELLSHYD-SDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSL 265

  Fly   409 RRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRR 472
            :.|::.|:.::::|...|.:........:|..::.|.|.:|..|: :|||||:||..:.||:||.
Human   266 KTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRF 330

  Fly   473 AFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMK 537
            ..::|...:|.:.:. :|||.|:..|||:|||||.||..|..::.|||||  |..:.:.|:..:|
Human   331 IVNQEEKLNLDDSQW-EDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAI--KKQDNNTRIEAVK 392

  Fly   538 ETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGV 602
            ..|.|||||:..|:|.|..||.|:.....:..|:.::|.||:.|.|||:.. |:|.:|.  .:..
Human   393 SLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAEN-ETGNMAI--HMVY 454

  Fly   603 QAVVTEYLIRNCHNIFDALDD 623
            |..:.|.::.....||.:.:|
Human   455 QNQIAELMLSEYSKIFGSEED 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	2/4 (50%)
		SH3_ARHGAP32_33	299..358	CDD:212769	14/79 (18%)
		RhoGAP_CdGAP	420..613	CDD:239849	68/193 (35%)
		FliJ	1322..1457	CDD:304890
ARHGAP15	NP_060930.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		PH	80..188	CDD:278594	19/110 (17%)
		PH_ARHGAP9-like	81..190	CDD:270053	19/111 (17%)
		RhoGAP_ARHGAP27_15_12_9	279..465	CDD:239868	68/191 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810