DRSC/TRiP Functional Genomics Resources

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Protein Alignment CdGAPr and Arhgap27

DIOPT Version :9

Sequence 1:NP_001260600.1 Gene:CdGAPr / 35267 FlyBaseID:FBgn0032821 Length:1843 Species:Drosophila melanogaster
Sequence 2:NP_001192165.1 Gene:Arhgap27 / 544817 MGIID:1916903 Length:869 Species:Mus musculus


Alignment Length:577 Identity:145/577 - (25%)
Similarity:239/577 - (41%) Gaps:105/577 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 PGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAH-- 137
            |...|.::.||.         .|...||  .|:...|.|:..:...|  ..||:....::..:  
Mouse   362 PETDYPELLASY---------PEEDYSP--VGSFSDPGPASPLVAPP--GWSCQITPDKQMLYTN 413

  Fly   138 -FHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPH------SSLRSFSPESCWFIIRVCPQ 195
             |..|:      .|:|.|...:....:....|:..:||.      .|:|..|.:|      ..|.
Mouse   414 QFTQEQ------WVRLEDQHGKPYFYNPEDSSVQWELPQVPIPAPRSVRKSSQDS------DTPA 466

  Fly   196 RCEPFLIKRSFENMQLLDE--MLHRCVYDRKISGLRNMEELAAELPSE-------SDVEYAVAKY 251
            :..|     ..|.::.||:  :|||.....|...||......:....|       .|.:.:.|..
Mouse   467 QASP-----PEEKIKTLDKAGVLHRTKTVDKGKRLRKKHWSTSWTVLEGGVLTFFKDSKTSAAGG 526

  Fly   252 LERFSKIASDSLTC---GTILTWLQLDNKGRR----LPLADG-------ETQRTINTPAVGAAYG 302
            |.:.||:::...|.   |..|:|...|...::    |...||       :::..|:|.....|.|
Mouse   527 LRQPSKLSTPEYTVELKGASLSWAPKDKSSKKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAEG 591

  Fly   303 VRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPR 367
            :....|   |.:..|.|:..|. |..|......||                        .:.|.:
Mouse   592 ISELSA---DLLQGEEGEPSSA-DFGSSERLGSWR------------------------EEDVRQ 628

  Fly   368 NFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLN 432
            |...|:...|.|::.    :.|...||    |.|:..||:.:.|:..|..:::||.|.|::....
Mouse   629 NAASPSLSPGGLESD----LSRVRHKL----RKFLQRRPTLQSLRDKGYIKDQVFGCALAQLCER 685

  Fly   433 SGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSS 496
            ....:|..::.|...:|..|: |||:||:||..:.||:||...|.:...||.:... :|:|.::.
Mouse   686 ERSPVPRFVQQCIRTVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITG 749

  Fly   497 LLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKV 561
            .||::|||||.||..:..:..|:.||  |..:..:|.|.:::.|..||.|:..||:.|.:||.:|
Mouse   750 ALKLFFRELPEPLFPFSHFHQFIAAI--KLQDPAQRSRCVRDLVRTLPAPNQDTLRLLIQHLCRV 812

  Fly   562 SQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIF 618
            .:|..:..||.:|:|||:.|.||| |.:|...:...  :..|..|.|.::..|.:||
Mouse   813 IEHGEQNRMTVQNVAIVFGPTLLR-PEMEEASMPMT--MVFQNQVVELILHQCADIF 866

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CdGAPrNP_001260600.1 PX_domain 168..274 CDD:295365 28/123 (23%)
SH3_ARHGAP32_33 299..358 CDD:212769 11/58 (19%)
RhoGAP_CdGAP 420..613 CDD:239849 65/193 (34%)
FliJ 1322..1457 CDD:304890
Arhgap27NP_001192165.1 SH3_ARHGAP27 10..66 CDD:213002
PRK12323 <68..249 CDD:237057
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..134
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..300
PRP40 241..>328 CDD:227435
WW 248..278 CDD:395320
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..401 11/51 (22%)
WW 418..445 CDD:395320 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..477 9/44 (20%)
PH_ARHGAP9-like 480..594 CDD:270053 24/113 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..642 5/18 (28%)
RhoGAP_ARHGAP27_15_12_9 675..861 CDD:239868 64/191 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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