DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Arhgap32

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_006510505.1	Gene:	Arhgap32 / 330914	MGIID:	2450166	Length:	2103	Species:	Mus musculus

Alignment Length:	1822	Identity:	496/1822 - (27%)
Similarity:	733/1822 - (40%)	Gaps:	498/1822 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ESSCSPPIQGAVPPPKPSRHMAVQPLNSKSC---------------------------------R 128
            |.:.|...:||..|..|.      .|..|||                                 .
Mouse    69 EETLSAMARGADVPEIPG------DLTLKSCGSTASTKVKHVKKSTPPGLMGCDNIHRLPFTKGH 127

  Fly   129 FPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVC 193
            |||:.||||||||.|:.|.:.:.|.::::|.|.:...|:.|                 .:::::.
Mouse   128 FPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKEL-----------------VYLVQIA 175

  Fly   194 PQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKI 258
            .|. :.:::|||:|:.::||:.||.|:|||:.|.|..:........|...|...:..||.|.|.|
Mouse   176 CQG-KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLTELPRSDVLKDSPESVTQMLTAYLSRLSTI 239

  Fly   259 ASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMIS 323
            |.:.:.||..|||:::||||..|.:.:   :.:|||||||||:.::||.|:||||:.:||||::|
Mouse   240 AGNKINCGPALTWMEIDNKGNHLLVHE---ESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVS 301

  Fly   324 VIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVL 388
            |||||....|.|||||..      ::||.||..||..|..|||::.....|          |||.
Mouse   302 VIDMPPKVLSTWWRGKHG------FQVGLFPGHCVELINQKVPQSVTNSVP----------KPVS 350

  Fly   389 RKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV 453
            :||||||.|.|:|:.|||::::|||.||.:||||.|||.|||||||.::|.||:||..|||.||:
Mouse   351 KKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI 415

  Fly   454 IDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNF 518
            :||||||||:.|||||||..||.|.||||......||||:|.||.|:|||||||||.|||||:.|
Mouse   416 VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKF 480

  Fly   519 VEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNL 583
            .:|:....||  |||..:.:.:.:|||||||||::|..||..::.:...|.|..|||||||||||
Mouse   481 SDAVSAATDE--ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 543

  Fly   584 LRSPALES---GGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGE 645
            |||..:||   .|.||...|.:|:||.|:::.:...:|.      .:.|.|....||:
Mouse   544 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFS------GKISAVMQEGAAS------- 595

  Fly   646 LRLESLTDCESLLVEQREQDQSLGVVERPKSL--STGGAKLISLEEAQERHSRVEGADLKQSLPI 708
                                     :.|||||  |:...||::|||||.|      ...:.|.||
Mouse   596 -------------------------LSRPKSLLVSSPSTKLLTLEEAQAR------TQAQVSSPI 629

  Fly   709 SMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAP--RSWQKRKPDKTP--SWKSIFS---- 765
                 .:.|      .|||||.||::|..|:|||:..|  |...:.|..|:|  ||:|.|:
Mouse   630 -----VTEN------KYIEVGEGPAALQGKFHTVIEFPLERKRPQNKMKKSPVGSWRSFFNLGKS 683

  Fly   766 -----RSQRQGNPDPGQKITTDVKD--------SVASRVSFVQASHAHASKELTKHDKPKSIELL 817
                 |..::...:|.:.....:|.        |..|..|...........:|.:..:|:|....
Mouse   684 SSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDA 748

  Fly   818 ETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDS---------YFDLLQSPQRGHMTTCPSR 873
            .:.|...|.    |..|.||.|:|         .||:         :...|.||...........
Mouse   749 LSASFNGDV----LGNRCNSYDNL---------PHDNESEEEVGLLHIPALVSPHSAEDVDLSPP 800

  Fly   874 ELSELGLNFDR-----EEPEMRIFSESESLVS---------------SPRV------GKENVPPA 912
            ::....|:||.     ..|:    :|||.|.|               ||..      |.::..|.
Mouse   801 DIGVASLDFDPMSFQCSPPK----AESECLESGASFLDSLGYTRDKLSPSKKDAEAGGSQSQTPG 861

  Fly   913 SGSATRRIMRAR-------------PEDFSSQTNSVNP------SPK------KQPRLNLLSPSS 952
            |.:::..:...:             .:|.||:.:|...      |||      |.|.:|:..|.|
Mouse   862 STASSEPVSPVQEKLSPFFTLDLSPTDDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMNISEPIS 926

  Fly   953 ARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEV 1017
            . |:||......||.|::.      |:|..                       ||:..:  |||.
Mouse   927 V-TLPPRVSEVIGTVSNTV------AQNAS-----------------------PTSWDK--SVEE 959

  Fly  1018 HPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQKQ 1082
            ...     .|:||.....|........:.....|..|     ..:|.|.|.....||..:|....
Mouse   960 RDV-----INRSPTQLQLGKMKAGEREAQETCEPEAQ-----PLEQGAAEEVELPGTEERPVLSS 1014

  Fly  1083 ESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPR-YSLLLCDTESSDNSSAVNT 1146
            :|.|. |...:..||....|..:||....:.| :|.|..|....| .:|.|.::....:|..:..
Mouse  1015 QSKAV-PSGQSQTGAVTHDPPQDPVPVSSVSL-IPPPPPPKNVARMLALALAESAQQASSQTLKR 1077

  Fly  1147 PQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHESLGQN---INNHHDAEQRDM 1208
            |         .::.:|.:.....        .|..|...|.||:.||..:   ......|||
Mouse  1078 P---------GASQAGCTSYGDT--------AVVPSEEKLPSSYSSLTLDKTCFQTDRPAEQ--- 1122

  Fly  1209 NALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGY 1273
                         ..|::....|....||       .|||| ..|..||.||:          |.
Mouse  1123 -------------FHPQINGLGNCNQPLP-------EAAAM-GGPTQSNTTDS----------GE 1156

  Fly  1274 QHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSPEKEKKPSAIL--ETNFD 1336
            |..|..|..:||.....|.                           .|||.:..||.|  ....|
Mouse  1157 QLHQVDLIGNSLHRNHISG---------------------------DPEKARSTSAPLTDSEKSD 1194

  Fly  1337 ENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEE--QHDGGA----YKAAEMTQQ-----LLQL 1390
            ::..:.:....::||:.|:.:..::|.|.....::  .:.|.:    :.::|:|.:     .|..
Mouse  1195 DHGSFPEDHAGKSSVSTVSFLEQDQSPLHFSCGDQPLSYLGTSVDKPHHSSELTDKSPMPSTLPR 1259

  Fly  1391 EQEHHDHEEQQEK-----------------EPEDEEQSQLLYE------------------NIEL 1420
            ::.||......|:                 ||.:.|.|::|.|                  |..|
Mouse  1260 DKAHHPLSGSPEENSSTATMAYMMATPARAEPSNSEASRVLAEQPSAADFVAATLQRTHRTNRPL 1324

  Fly  1421 RKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSSPSKSP-----TFSVKELA 1480
            ..|.:..           ..||.|.|.:::  ...|:..|..|:....:.:|     :.::.:.|
Mouse  1325 PPPPSQR-----------PAEQPPVVGQVQ--EAPSIGLNNSHKVQGTAPAPERPPESRAMGDPA 1376

  Fly  1481 NKF-------------ESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMP-------APVPLKK-- 1523
            ..|             .|:|...||.   .||..|...|..|.. ::.|       ||||..:
Mouse  1377 PIFLSDGTAAAQCPMGASAPQPGLPE---KVRESSRAPPLHLRA-ESFPGHSCGFAAPVPPTRTM 1437

  Fly  1524 -------LNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSF-DFTRPK-T 1579
                   |:|||...|.|.:.::||.  ....:.|: :...||....:..|::.:: .|.||. |
Mouse  1438 ESKMAAALHSSAADATSSSNYHSFVP--SSASVDDV-MPVPLPVSQPKHASQKIAYSSFARPDVT 1499

  Fly  1580 LNP--PKRLPGMSITEEICQKRVGEMEAITPTTENRISLIQ----QNNMPKEQQSSANQFLPPAG 1638
            ..|  |:.....::|.. ||.|...:    |...|::...|    ::..|.......|.::.| |
Mouse  1500 AEPFGPENCLHFNMTPN-CQFRPQSV----PPHHNKLEPHQVYGARSEPPASMGPRYNTYVAP-G 1558

  Fly  1639 RKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLKSRSRTELNSEDNFPAAESLRIKSKSRGDM 1703
            |.  ::|             ...:..::..|..:|.|..|.....||..|.....|::|     :
Mouse  1559 RN--MSG-------------HHSKPCSRVEYVSSLGSSVRNPCCPEDILPYPTIRRVQS-----L 1603

  Fly  1704 HA 1705
            ||
Mouse  1604 HA 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	29/105 (28%)
		SH3_ARHGAP32_33	299..358	CDD:212769	29/58 (50%)
		RhoGAP_CdGAP	420..613	CDD:239849	112/195 (57%)
		FliJ	1322..1457	CDD:304890	31/182 (17%)
Arhgap32	XP_006510505.1	PX_RICS	141..255	CDD:132831	35/131 (27%)
		SH3_ARHGAP32_33	277..330	CDD:212769	29/58 (50%)
		RhoGAP_CdGAP	382..576	CDD:239849	112/195 (57%)
		PHA03247	<1251..1633	CDD:223021	79/401 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836272
Domainoid	1	1.000	194	1.000	Domainoid score	I3163
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		otm43987
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.730