Protein Alignment CdGAPr and Arhgap32

DIOPT Version :9

• Sequence 1: NP_001260600.1
• Gene: CdGAPr / 35267
• FlyBaseID: FBgn0032821
• Length: 1843
• Species: Drosophila melanogaster
• Sequence 2: XP_017451485.1
• Gene: Arhgap32 / 315530
• RGDID: 1305267
• Length: 2100
• Species: Rattus norvegicus
• Alignment Length: 1758
• Identity: 478/1758 - (27%)
• Similarity: 698/1758 - (39%)
• Gaps: 528/1758 - (30%)

  Fly    42 KDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQG 106
            :.|..|.:..::...:...:|.:..|.|...:.|||        |....|...       |..:|
  Rat    77 RGADVPEIPGDLTLKSCGSTASMKVKHVKKSTPPGL--------MGCDNIHRL-------PFTKG 126

  Fly   107 AVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGG 171
                                 .|||:.||||||||.|:.|.:.:.|.::::|.|.:...|:.|
  Rat   127 ---------------------HFPKMAECAHFHYENVEFGSIQLSLSEEQNEIMKNGCESKEL-- 168

  Fly   172 DLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAA 236
                           .:::::..|. :.:::|||:|:.::||:.||.|:|||:.|.|       :
  Rat   169 ---------------VYLVQIACQG-KSWIVKRSYEDFRVLDKHLHLCIYDRRFSQL-------S 210

  Fly   237 ELP-------SESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINT 294
            |||       |...|...:|.||.|.|.||.:.:.||..|||:::||||..|.:.:   :.:|||
  Rat   211 ELPRSDILKDSPESVTQMLAAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHE---ESSINT 272

  Fly   295 PAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVA 359
            ||||||:.::||.|:||||:.:||||::||||||....|.|||||..      ::||.||..||.
  Rat   273 PAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHG------FQVGLFPGHCVE 331

  Fly   360 TIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNC 424
            .|..|||::.....|          |||.:||||||.|.|:|:.|||::::|||.||.:||||.|
  Rat   332 LINQKVPQSVTNSVP----------KPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGC 386

  Fly   425 DLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQ 489
            ||.|||||||.::|.||:||..|||.||::||||||||:.|||||||..||.|.||||......|
  Rat   387 DLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQ 451

  Fly   490 DIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYL 554
            |||:|.||.|:|||||||||.|||||:.|.:|:....||  |||..:.:.:.:|||||||||::|
  Rat   452 DIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE--ERLIKIHDVIQQLPPPHYRTLEFL 514

  Fly   555 AEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALES---GGVAALRGVGVQAVVTEYLIRNCHN 616
            ..||..::.:...|.|..||||||||||||||..:||   .|.||...|.:|:||.|:::.:...
  Rat   515 MRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDV 579

  Fly   617 IFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSL--ST 679
            :|.      .:.|.|....||            |||                    |||||  |:
  Rat   580 LFS------GKISAVMQEGAA------------SLT--------------------RPKSLLVSS 606

  Fly   680 GGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNA---ASNIGSYIEVGGGPSSLPDKYHT 741
            ...||::|||||.|                  |.|..|:   ..|  .|||||.||::|..|:||
  Rat   607 PSTKLLTLEEAQAR------------------TQAQVNSPIVTEN--KYIEVGEGPAALQGKFHT 651

  Fly   742 VLSAP--RSWQKRKPDKTP--SWKSIFS---------RSQRQGNPDPGQKITTDVKD-------- 785
            ::..|  |...:.|..|:|  ||:|.|:         |..::...:|.:.....:|.
  Rat   652 IIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLR 716

  Fly   786 SVASRVSFVQASHAHASKELTKHDKPK-SIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRS 849
            |..|..|...........:|.:..:|: |.:.|..:.|..     .|..|.||.|:|
  Rat   717 SAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGE-----VLGNRCNSYDNL-------- 768

  Fly   850 VSHDS---------YFDLLQSPQRGHMTTCPSRELSELGLNFDR-----EEPEMRIFSESESLVS 900
             .||:         :...|.||...........::....|:||.     ..|:    :|||.|.|
  Rat   769 -PHDNESEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPK----AESECLES 828

  Fly   901 SPRV---------------------GKENVPPASGSATRRIMRAR-------------PEDFSSQ 931
            ....                     |.::..|.|.:::..:...:             .||.||:
  Rat   829 GASFLDSLGFTRDKLGASKKDVEAGGSQSQTPGSTASSEPVSPVQEKLSPFFTLDLSPTEDKSSK 893

  Fly   932 TNSVNP------SPK------KQPRLNLLSPSSARTMPPPPLSAPGTASSSCGH----------- 973
            .:|...      |||      |.|.:|:..|.|. |:||......||.|::...
  Rat   894 PSSFTEKVVYAFSPKIGRKLSKSPSMNISEPISV-TLPPRVSEVIGTVSNTVSQNASPPSWDKSV 957

  Fly   974 -------------------ESGGAENCCKRYKLEDQLCDIQFIDCGTPEN---------VPTTQQ 1010
                               |....|.|....:.::|....:....||.|.         ||:.|.
  Rat   958 EERDVINRSPTQLGKMKPGEREAQERCEPEAQPQEQGAAEEVELPGTEERPVSSSQSKAVPSGQS 1022

  Fly  1011 Q--------------FASVEVHPPPKPAR--------------------------ANQSPISSSN 1035
            |              .:||.:.|||.|.:                          .:|:..:|..
  Rat  1023 QTGAVTHDPPQDPVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQTLKRPGPSQAGCTSYG 1087

  Fly  1036 GASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQ----GTFTQPGQKQESSA---PRPVHST 1093
            ..:|.:|......||.||.|.....:.....|:|..|    |...||  ..|::|   |...::|
  Rat  1088 DMAVATSEEKLPSSYSSVTLDKTYFQTDRPAEQFHLQINGLGNCDQP--LPETAAMGGPTHPNTT 1150

  Fly  1094 NNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTS 1158
            ::|..|.  :|:.:.:...:.|:......|||.  |..|.|:|.||...:.....         :
  Rat  1151 DSGEQLH--QVDLIGNSLHRNHLSGDPEKARST--SAPLADSEKSDGHGSFPEDH---------A 1202

  Fly  1159 AMSGVSGVSSNVQQQQLL--LGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLD-LN 1220
            ..:.||.||...|.|..|  ...|...||||:|.:      ..||.:|..:.:.:...|..| .:
  Rat  1203 GKTSVSTVSFVGQGQSPLHFSSGDQPLSYLGTSMD------KPHHSSELTEKSPMPSTLPRDKAH 1261

  Fly  1221 PLQPRLPQPANRAATLP--------VKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQ 1277
            ||... |:.....||:.        .:...:.|:.||...|..::|...|             ||
  Rat  1262 PLSGS-PEENTSTATMAYMMTTPPRAETSTREASRAMAEQPTAADFVAAT-------------LQ 1312

  Fly  1278 RQLSMHSLLATDESSPVYEDFEQTP----VKMVPS-PIKSTISITYKSPEKEKKPSAILETNFDE 1337
            |   .|.........|.....||.|    |:..|| .:.::..:...:|..|:.|        :.
  Rat  1313 R---AHRTNRPLPPPPSQRPTEQPPGVGQVQEAPSIGVNNSHKVQGAAPAPERPP--------EP 1366

  Fly  1338 NTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQE 1402
            ..:.:...:|.:                        ||.|  ||:....:          ...|.
  Rat  1367 RAMADPAPIFVS------------------------DGSA--AAQCPMAI----------SAAQP 1395

  Fly  1403 KEPEDEEQSQLLYENIELRKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSS 1467
            ..||...:|.        |.|..   :||.|                                :.
  Rat  1396 GLPEKVRESS--------RAPPL---HLRAE--------------------------------TF 1417

  Fly  1468 PSKS--------PTFSVK-ELANKFESSPVE--QLPNFDFSVRGGSMKKPNELSVPKTMPAPVPL 1521
            |..|        ||.:|: ::|....||..|  ...|:...|       |:..|....:|.|.|:
  Rat  1418 PGHSCGFAAPVPPTRTVESKMAAAMHSSAAEANNSSNYHSFV-------PSSASADDVLPLPPPI 1475

  Fly  1522 KKLNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSFDFT-------RPKT 1579
            .:...::|||..|    :|.|                |:|.:|.........|.       ||::
  Rat  1476 AQPKHASQKIAYS----SFAR----------------PDVTTEPFGPENCLHFNMTPNCQFRPQS 1520

  Fly  1580 LNP 1582
            :.|
  Rat  1521 VPP 1523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	33/112 (29%)
		SH3_ARHGAP32_33	299..358	CDD:212769	29/58 (50%)
		RhoGAP_CdGAP	420..613	CDD:239849	112/195 (57%)
		FliJ	1322..1457	CDD:304890	17/134 (13%)
Arhgap32	XP_017451485.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339930
Domainoid	1	1.000	194	1.000	Domainoid score	I3072
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		oto98201
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.840