DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and Arhgap22

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_038950392.1	Gene:	Arhgap22 / 306279	RGDID:	1307237	Length:	722	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	170/839 - (20%)
Similarity:	286/839 - (34%)	Gaps:	279/839 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 RRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHL 343
            |...|..||..|:...|.             ||.::              .|.....|..|:..:
  Rat    19 RSKSLVMGEQSRSPGRPL-------------APHKL--------------GPVLKAGWLRKQKSI 56

  Fly   344 QKSLYEVGFF----------------PQSCVATIGDKVPRNFPMPAPLVGHL-DASPTKPVLRKH 391
            .|:..:..|.                ||..::..|.:|....|.|.....|| :.:|.....|:
  Rat    57 MKNWQQRWFVLRGDQLFYYKDKDEGKPQGFISLQGTQVTELLPDPDDPGKHLFEITPGGAAERE- 120

  Fly   392 GKLIAFFRSFILSRPSRRRLK------------------------------QSGIYRERVFNCDL 426
             |:.|...:.:|...|:|.::                              .:||:.:|:.  |.
  Rat   121 -KVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGTSRSSHAHPVEPLSTGIFGQRLE--DT 182

  Fly   427 SEHLLNSGQDI-PMVLRSCAEFIENYGVI-DGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQ 489
            ..|....|..: |:::..|.:||...|:. :|::|:.|..:.::.|:.:||....|..   :...
  Rat   183 VHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLF---DSTT 244

  Fly   490 DIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQ-VKADEADERLRLMKETVLKLPPPHYRTLKY 553
            |:|.|:||||:|.||||.|:..:..|::|:...| :..||.:..:.|.|: |..||..:|..|:|
  Rat   245 DVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQ-VSNLPQANYNLLRY 308

  Fly   554 LAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIF 618
            :...|.:|..|.....|:.:|||.|:.||:|| |.:|. .|..:.|..:...:...|||....:|
  Rat   309 ICRFLDEVQAHSDVNKMSVQNLATVFGPNILR-PQVED-PVTIMEGTSLVQHLMTVLIRKHGQLF 371

  Fly   619 DALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAK 683
                           ||.:....|.                              |:....|..:
  Rat   372 ---------------ATPSFEEPAS------------------------------PRGTVQGTVE 391

  Fly   684 LISLEEAQERHSRVEGADLKQSLPISMLTSASSNAAS--------NIGSYIEVGGGPSSLPDKYH 740
            ..| ||....|   :|......||....:|....||:        .:||  :.|...:|...:.|
  Rat   392 WGS-EEVTRDH---QGEPGSSGLPTHRTSSLDGPAAAVLSRTSPPRLGS--QAGPAATSPGKRMH 450

  Fly   741 TVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKEL 805
            |:               |.|||.|   ::||
  Rat   451 TL---------------PGWKSSF---RQQG---------------------------------- 463

  Fly   806 TKHDKPKSIELLETTSNERDPKPMDLCIRS-------NSIDSLRTVGHSRSVSHDSYFDLLQSPQ 863
            ::.:.||.:.           ..:::.|.|       |.:.|||:  |.|:.|.|...|
  Rat   464 SRSESPKGVS-----------SSLEVPIISSGGNWLINGLSSLRS--HRRASSGDRLKD------ 509

  Fly   864 RGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDF 928
                 |..::.||    .:|...|...:.|.:....::..|...:...:.||.|  ..||.....
  Rat   510 -----TGSAQRLS----TYDNVPPSSHLSSTASVASTAWSVASSSREASIGSCT--ACRASNSSA 563

  Fly   929 SSQTN---SVNPSPKKQPRLNLLSPSSARTMPPPPL----------------SAPGTASSS---- 970
            .|..:   ::.|||         .|||:...|.|.|                :.||:.|.:
  Rat   564 CSSLHTEWALEPSP---------LPSSSEGHPSPDLGHSLDEACVGSGSSEPNDPGSPSQAHVRR 619

  Fly   971 CGHESG-----GAENCCKRYK-------LEDQLCDIQFIDCGTPENVPTTQQQFASVEV 1017
            |....|     .||.|.:|.:       :|:...|::...|...|.:...::::|.:|:
  Rat   620 CRALQGQVAELRAELCHQRIEYQRSLKSIEEGNSDLRKQMCRLEEELDQEKKKYAMLEI 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769	9/74 (12%)
		RhoGAP_CdGAP	420..613	CDD:239849	60/195 (31%)
		FliJ	1322..1457	CDD:304890
Arhgap22	XP_038950392.1	PH-like	42..157	CDD:418428	20/116 (17%)
		RhoGAP_ARHGAP22_24_25	173..371	CDD:239855	63/205 (31%)
		SMC_prok_B	<614..>704	CDD:274008	12/65 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910