DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Arhgap31

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001099349.1	Gene:	Arhgap31 / 288093	RGDID:	1306093	Length:	1428	Species:	Rattus norvegicus

Alignment Length:	1538	Identity:	368/1538 - (23%)
Similarity:	567/1538 - (36%)	Gaps:	438/1538 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 SRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQ 468
            ::.::::||:.|  ....|.|||:|:|.:||||:|.||:|||||||.:|::||||||||:|||||
  Rat     3 NKGAKQKLKRKG--AASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQ 65

  Fly   469 RLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERL 533
            |||:.|..::.|||......||||.|.||.|:|||||||||.||:||:.|.||:....:|.  :|
  Rat    66 RLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEG--QL 128

  Fly   534 RLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALES---GGVA 595
            ..::..:.:|||||||||:||..||..::....:|.|..:|||:|||||||||..:|:   .|.|
  Rat   129 ARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKIEATICNGDA 193

  Fly   596 ALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVE 660
            |...|.||.||.|:::.:...||:                   ..|.|...:.||.|..:||
  Rat   194 AFLAVRVQQVVIEFILNHADQIFN-------------------GGAPGALQQDESRTITKSL--- 236

  Fly   661 QREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSY 725
                  :|..:..|       .||:||||||.|               |:.|:..:.......|.
  Rat   237 ------TLPALSLP-------MKLVSLEEAQAR---------------SLATNHPARKERRENSL 273

  Fly   726 IEVGGGPSSLPDKYHTVLSAPRSWQKRK-PDKTPSWKSIF----------SRSQRQGN------- 772
            .|:   ..|:...:||||..|.:  ||| ..|:..|||||          |:..|.|:
  Rat   274 PEI---VPSMGTPFHTVLELPDN--KRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQR 333

  Fly   773 --------------------PDPGQKITTDVKDSVASRVSFVQASHAHASK-----ELTKHDK-- 810
                                |..|::...:...:|.:...|:.|:..|||.     :|:|..:
  Rat   334 LSVEKATIRPAKSMDSLCSVPVEGKENKGNFNRTVTTGGFFIPATKMHASSTGSSCDLSKEGEWS 398

  Fly   811 ---------------------PKSIELL----ETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSV 850
                                 |:.:::.    :..|.:..||.:.:...|:  ||     ..:||
  Rat   399 QEGMPAGAEGGCEVGGQIRPLPEQLKVFRPIGDPESEQSAPKLLGMFYTSS--DS-----PGKSV 456

  Fly   851 SHDSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGS 915
            ...|.|.:..||:.           ....||.  .||    |:.|..|..|..:...:.|
  Rat   457 FTSSLFQMEPSPRH-----------QRKALNI--SEP----FAVSVPLRVSAVISTNSTP----- 499

  Fly   916 ATRRIMRARP---------EDFSSQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSC 971
                 .|..|         |:||.|.:.....|:::      .|..|...|........|..:..
  Rat   500 -----CRTPPKELQSLSSLEEFSFQGSESGGWPEEE------KPLGAEPFPGSVPKKAATEDTKP 553

  Fly   972 GHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNG 1036
            .||:.|...|.:...|          |.|||....|......|.....|.|...|.:: :..|.|
  Rat   554 EHEAPGRAECNQSLPL----------DPGTPLEKKTLDISLGSQLSKEPEKWPNAEKA-MEESQG 607

  Fly  1037 ASVGSSSSSTRYSYPSVQLGAKRK-------EQQDAKERFSYQGTFTQPGQKQE----------S 1084
            |      |.|:.|.|.....|:.|       ::.|..:...:      |..:||          |
  Rat   608 A------SQTKLSTPQESPRARTKPVLLHEMDEDDLAQALIW------PEIQQELKIIESEEEFS 660

  Fly  1085 SAPRPVHSTNNGATLRKPRVE--PVEDGQIKLHVPTPTTPARSPRYSL-LLCDTESSDNSS---- 1142
            |.|.|...|:       |..|  |..       .|:|..|...|..|. |...|..|.|.|
  Rat   661 SLPPPAQKTS-------PMTESSPAP-------FPSPEAPESLPSSSAPLEVWTRDSANQSIQET 711

  Fly  1143 AVNTPQYDMEP---LMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAE 1204
            |:.|.:..:||   |:.:.:...||...|.:...::||....||    .:...:|...|
  Rat   712 AILTNREKLEPVCSLLESESEQAVSPDPSTLAPLEILLFEKVSS----PARIEIGGPGN------ 766

  Fly  1205 QRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSN---------FTD 1260
                          |:|..|..|.|..     |::::.|...:.  ..|:..:         :|:
  Rat   767 --------------LSPPLPPAPPPPT-----PLEEEPQVLLSH--EGPDREDASRDSRTDLYTE 810

  Fly  1261 NTSQSVTPSEYGYQHL-QRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSPEKE 1324
            ..:...:|   |...| ||:   .::.:.:|.....:...::....:|||.|....|    |::|
  Rat   811 QPNSEDSP---GIPRLCQRE---EAIASPNEKQDAKQAVPESKDPGLPSPTKEVEVI----PQEE 865

  Fly  1325 KKPSAILETNFD---ENTVYEQVKLFRNSVTE------VNQMLHERSSLKQIAEEEQHDGGAYKA 1380
            ...|...:...|   ::||.:..:.....|..      |...||. .:||:|.|.:......::.
  Rat   866 GDASHSAQEPSDCDEDDTVIDTAQHGLEMVEPWEEPQWVTSPLHS-PTLKEIQESQTQGSQGHRL 929

  Fly  1381 AEMTQQLLQLEQEH--------HDH--------------EEQQEKEPEDEEQSQLLYENIELRKP 1423
            ....:....|.|.|        ..|              |.::..||.....:::....:|.:..
  Rat   930 ERRLRHRPSLRQSHSLDSKTTGQSHWALEAPFSSSCASLETERNYEPLQTPSARIKIAGLEEKAL 994

  Fly  1424 KTV--YENLRGEEM-----------------KFIT----EEQKPNVD----RIELDSLDSLPDNM 1461
            |..  :..|:|.|:                 .||:    :||.|.::    :|:.:.:.. ||:
  Rat   995 KAFREFSGLKGLEVLPSQKGSSGIQPKPVETNFISLTEGKEQGPQLEFSNPQIKHNDVPG-PDS- 1057

  Fly  1462 EHEQSSPSKSPTFSVKELANKFESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMP---------- 1516
             .|.|||....:.|..|...|.:....|..|:     :|  ..:|:.|::...:|
  Rat  1058 -SEGSSPGAQDSTSPGEHPLKLQLKSTECGPS-----KG--KHRPSSLNLDSAIPIADLFRVENG 1114

  Fly  1517 ----AP-VPLKKLNSSAQKITRSLDENAFVREFGGKQLQDLSL--------SNKLPEVMSEVNS- 1567
                :| :.|.:|..:  |:............:..:..|||.:        .|..|..:|.|.:
  Rat  1115 ASFSSPGIELSELGDT--KVIWMSSSQGKAAPWSSQDTQDLGIVAHALTGRRNSAPVSVSAVRTS 1177

  Fly  1568 ------RRKSFDFTRPKT--LNPPKRLPGMSITEEICQ--KRVGEMEAITPTT-------ENRIS 1615
                  :.|:.....||.  ...|:.||..:..|...|  :|..|....||.|       ::..|
  Rat  1178 FMVKMCQAKAVPVIPPKIQYTQIPQPLPSQNTGEGGAQPPERNQEEPGSTPETPQKPTKDDSPSS 1242

  Fly  1616 LIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLKSRSRTE 1680
            |    ..|:|:|....|....:.||...|..|.:...............:|...|...|..|.||
  Rat  1243 L----GSPEEEQPKQEQGASASRRKASTTSCVAEGSFCSAEPGPSTLVSSQDAMGQCRKRTSETE 1303

  Fly  1681 LNSEDNFPAAESLRIKSKSRGDMHALQKDIDMNLKQLSRVTGG 1723
             .||||.       :.||                  |.|.:||
  Rat  1304 -PSEDNL-------LSSK------------------LERASGG 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769
		RhoGAP_CdGAP	420..613	CDD:239849	104/195 (53%)
		FliJ	1322..1457	CDD:304890	31/192 (16%)
Arhgap31	NP_001099349.1	RhoGAP_CdGAP	17..211	CDD:239849	104/195 (53%)
Arhgap31	NP_001099349.1	DUF966	<1189..>1306	CDD:283735	28/121 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339931
Domainoid	1	1.000	194	1.000	Domainoid score	I3072
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.800