DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and ARHGAP30

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001020769.1	Gene:	ARHGAP30 / 257106	HGNCID:	27414	Length:	1101	Species:	Homo sapiens

Alignment Length:	1234	Identity:	304/1234 - (24%)
Similarity:	456/1234 - (36%)	Gaps:	388/1234 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 SRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLR 471
            ||::.|:.|..:||||.|||.|||.:|||::|.||:|||||:|.|||:||||||||::||||:||
Human     3 SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSNIQKLR 67

  Fly   472 RAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLM 536
            :.|:.||.|||......||||.||||.|.||||||:||.||:|||.|.||:.|:.:  .|||..:
Human    68 QEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLE--PERLVKI 130

  Fly   537 KETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALES---GGVAALR 598
            .|.:.:||.|:||||::|..||..::....:|.|..:|||||||||||||..:|:   .|.||..
Human   131 LEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFM 195

  Fly   599 GVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQRE 663
            .|.||::|.|:::.:...:|                  ..|..:|||:        ||
Human   196 EVRVQSIVVEFILTHVDQLF------------------GGAALSGGEV--------ES------- 227

  Fly   664 QDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIEV 728
                 |....|.:.::|     |.|:...|       .|...||                |.::.
Human   228 -----GWRSLPGTRASG-----SPEDLMPR-------PLPYHLP----------------SILQA 259

  Fly   729 GGGPSSLPDKYHTVLSAPRSWQKRKPD-KTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVS 792
            |.||..: ..|||::....  .|||.. |...|:|||:.. |.|:.
Human   260 GDGPPQM-RPYHTIIEIAE--HKRKGSLKVRKWRSIFNLG-RSGHE------------------- 301

  Fly   793 FVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRT-----------VGH 846
                         ||...|:..|..|..||:...:|      :.|:|||..           ||.
Human   302 -------------TKRKLPRGAEDREDKSNKGTLRP------AKSMDSLSAAAGASDEPEGLVGP 347

  Fly   847 SRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNFD-------REEPEMRIFSESESLVSSPRV 904
            |             ||:       ||..|.| .|..|       .:|||......:.|...:||.
Human   348 S-------------SPR-------PSPLLPE-SLENDSIEAAEGEQEPEAEALGGTNSEPGTPRA 391

  Fly   905 GKENVPPASGSATRRIMRARPEDFSSQTN-----------SVNPSPKKQPRLNLLSPSSARTMP- 957
            |:..: .|.||:  |..|......|...|           ||.|        |::|..|...:.
Human   392 GRSAI-RAGGSS--RAERCAGVHISDPYNVNLPLHITSILSVPP--------NIISNVSLARLTR 445

  Fly   958 ----------PPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQF 1012
                      |.|.|.||...   |...|..:.     |||.........|.|..:..|..:...
Human   446 GLECPALQHRPSPASGPGPGP---GLGPGPPDE-----KLEASPASSPLADSGPDDLAPALEDSL 502

  Fly  1013 ASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQ 1077
            :               ..:..|......||||...:      :||:..|...|:.    .|....
Human   503 S---------------QEVQDSFSFLEDSSSSEPEW------VGAEDGEVAQAEA----AGAAFS 542

  Fly  1078 PG-----------------QKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARS 1125
            ||                 |.:|.|...|:...:            :::.|..|.....:..:..
Human   543 PGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLS------------LDEAQFVLAPSCCSLDSAG 595

  Fly  1126 PRYSLLLCDTESSDNSSAVNTPQY-DMEPLM-----LTSAMSGVSGVSSNVQQQQLLLGVDASSS 1184
            ||..:      ..:|...|....| |:.||:     :......:.|.::...:|.|..|.:..:.
Human   596 PRPEV------EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQAC 654

  Fly  1185 Y-LGSSHES-LGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAA 1247
            : :|...:: .|..::...:||.                 .|.....|.:|:    :|:.:|.
Human   655 WEVGEDKQAEPGGRLDIREEAEG-----------------SPETKVEAGKAS----EDRGEAG-- 696

  Fly  1248 AMCSSPNNSNFTDNTSQSVTPSEYGYQHLQ---RQLSMHSLLATDESSPVYEDFEQTPVKMVPSP 1309
                                    |.|..:   |:.|.....|.:|.|...:..:....|.|..|
Human   697 ------------------------GSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEP 737

  Fly  1310 IKSTISITYKSPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHD 1374
            .....     :.||||:    :|...||.....||:..|:              |:|.|:|:|
Human   738 GGDEY-----TDEKEKE----IEREEDEQREEAQVEAGRD--------------LEQGAQEDQ-- 777

  Fly  1375 GGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLY--------ENIELRKPKTVYENLR 1431
                 .||...:::|.:      |.:..:|.||:.|.:..|        :..:.|.|:...|...
Human   778 -----VAEEKWEVVQKQ------EAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGA 831

  Fly  1432 GEEMK------------------FITEE---QKPNVDRIELD-SLDSLPDNMEHEQSSPSKSPTF 1474
            ||..|                  ::.|:   :...|..:|:| :.:..|.:.|.|:.:|...
Human   832 GEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPP--- 893

  Fly  1475 SVKELANKFESSPVEQLPNFDFSVRGGSMKKPNEL-------SVPKTMPAPVPLKKLNSSAQKI 1531
            ..:|:..:.:.||...|......:.|..|:..:.|       |||...|.|...|..::...||
Human   894 QPEEMEPEGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKI 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769
		RhoGAP_CdGAP	420..613	CDD:239849	108/195 (55%)
		FliJ	1322..1457	CDD:304890	34/164 (21%)
ARHGAP30	NP_001020769.1	RhoGAP_CdGAP	16..210	CDD:239849	108/195 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..243		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..400		31/159 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..529		20/106 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..906		62/370 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1050..1101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146169
Domainoid	1	1.000	194	1.000	Domainoid score	I3172
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15729
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.800