DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and rga4

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_595756.1	Gene:	rga4 / 2540593	PomBaseID:	SPBC28E12.03	Length:	933	Species:	Schizosaccharomyces pombe

Alignment Length:	718	Identity:	158/718 - (22%)
Similarity:	274/718 - (38%)	Gaps:	209/718 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PIACHASTDKDA------QAPPLQFEMDAPAAAISAQLNFKIVPADSLP---------------- 75
            |:|.||......      |.|..:..::.|....|:.:|:|.|...:.|
pombe   292 PVAYHAFVQSPTENGTLPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIH 356

  Fly    76 --------------------------------GLS------------YQDMFASMNTSQISNA-- 94
                                            ||.            |..:|..::..::|:.
pombe   357 LRGALRDVTNKCNLKVPRNRNSLSNLDEYYVNGLESDETPTKARFPRYPTVFNKLDDKRLSSEPN 421

  Fly    95 --------STESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCR-----------FPKLEECAHFHY 140
                    |:....||..: ::...:.|.|.|.:|..::|..           |...||.|:
pombe   422 GLKKRLTNSSNYEASPRAK-SLNLSQVSLHQACEPEYNRSSLVRASDVFTSNVFDATEESAN--- 482

  Fly   141 ERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLI--- 202
                  .|::::.:.::| :|:.:        |..:||.|...:.    ..|.|:..:..|:
pombe   483 ------ELAIRISELQAE-VGTLL--------LEATSLASIIEQQ----TPVSPEAFKQELVADL 528

  Fly   203 -------KRSFENMQLLDEMLHRCVYDRKISGLRN-----MEELA------AELPS-ESDVEYAV 248
                   ::||: .:|...:|.|......:|.|:|     |||.|      .||.| .:.:|..:
pombe   529 NYRLDYLRKSFQ-PELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLEREL 592

  Fly   249 AKYL--ERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPA----------VGAAY 301
            | ||  ::..|..|.|...        .:|        |.::.|||:||:          |.::.
pombe   593 A-YLREQQHKKRTSSSFGI--------FNN--------DKKSNRTISTPSPRESFSRLQMVASSL 640

  Fly   302 GVRRYQAQAPDEINIEVG---DMISVIDM-PSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIG 362
            |.|     ..|..:.|.|   ...|.||: .|.::...|:....|:..:       |......:.
pombe   641 GFR-----PKDNKDKESGGYNKRNSKIDLKKSFSKRFHWKRDSPHMSST-------PSISEEHLA 693

  Fly   363 DKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFR---SFILSRPSRRRLKQSGIYRERVFNC 424
            .:...:|   .|.|||     .|...:...:|.|.::   |..:.|..:.:..:|.::.....:.
pombe   694 SEEQEDF---VPAVGH-----CKLCGKYSNELRAHYQDCVSSTIDRQYQSKKSESPVWALNPDDF 750

  Fly   425 DLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAF-DEERVPDLGNPEM 487
            |.:...|   ..:|.::.||..|||:||: .:|:||.||.||.::::.... :|:.|.|     .
pombe   751 DQNRLTL---LRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLD-----P 807

  Fly   488 KQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKA--DEADERLRLMKETVLKLPPPHYRT 550
            .:||.||:|:.|.|.|.||||:.||..|..|:.|....:  |:.|..:.::|    .|||.|...
pombe   808 SEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIK----SLPPAHAEI 868

  Fly   551 LKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCH 615
            |:.:..||.:|:.:.....||.||||:|::|.|:|.|. .|..|..:.   |:.....:||.:.|
pombe   869 LQLIIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPD-NSRDVIDMT---VKNYSLAFLIDHVH 929

  Fly   616 NIF 618
            .:|
pombe   930 EVF 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	29/129 (22%)
		SH3_ARHGAP32_33	299..358	CDD:212769	12/62 (19%)
		RhoGAP_CdGAP	420..613	CDD:239849	64/196 (33%)
		FliJ	1322..1457	CDD:304890
rga4	NP_595756.1	LIM	24..78	CDD:259829
rga4	NP_595756.1	RhoGAP	759..928	CDD:214618	62/181 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9312
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910