Protein Alignment CdGAPr and rga4

DIOPT Version :10

• Sequence 1: NP_610002.1
• Gene: CdGAPr / 35267
• FlyBaseID: FBgn0032821
• Length: 1843
• Species: Drosophila melanogaster
• Sequence 2: NP_595756.1
• Gene: rga4 / 2540593
• PomBaseID: SPBC28E12.03
• Length: 933
• Species: Schizosaccharomyces pombe
• Alignment Length: 718
• Identity: 158/718 - (22%)
• Similarity: 274/718 - (38%)
• Gaps: 209/718 - (29%)

  Fly    33 PIACHASTDKDA------QAPPLQFEMDAPAAAISAQLNFKIVPADSLP---------------- 75
            |:|.||......      |.|..:..::.|....|:.:|:|.|...:.|
pombe   292 PVAYHAFVQSPTENGTLPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIH 356

  Fly    76 --------------------------------GLS------------YQDMFASMNTSQISNA-- 94
                                            ||.            |..:|..::..::|:.
pombe   357 LRGALRDVTNKCNLKVPRNRNSLSNLDEYYVNGLESDETPTKARFPRYPTVFNKLDDKRLSSEPN 421

  Fly    95 --------STESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCR-----------FPKLEECAHFHY 140
                    |:....||..: ::...:.|.|.|.:|..::|..           |...||.|:
pombe   422 GLKKRLTNSSNYEASPRAK-SLNLSQVSLHQACEPEYNRSSLVRASDVFTSNVFDATEESAN--- 482

  Fly   141 ERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLI--- 202
                  .|::::.:.::| :|:.:        |..:||.|...:.    ..|.|:..:..|:
pombe   483 ------ELAIRISELQAE-VGTLL--------LEATSLASIIEQQ----TPVSPEAFKQELVADL 528

  Fly   203 -------KRSFENMQLLDEMLHRCVYDRKISGLRN-----MEELA------AELPS-ESDVEYAV 248
                   ::||: .:|...:|.|......:|.|:|     |||.|      .||.| .:.:|..:
pombe   529 NYRLDYLRKSFQ-PELSTLLLRRDALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLEREL 592

  Fly   249 AKYL--ERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPA----------VGAAY 301
            | ||  ::..|..|.|...        .:|        |.::.|||:||:          |.::.
pombe   593 A-YLREQQHKKRTSSSFGI--------FNN--------DKKSNRTISTPSPRESFSRLQMVASSL 640

  Fly   302 GVRRYQAQAPDEINIEVG---DMISVIDM-PSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIG 362
            |.|     ..|..:.|.|   ...|.||: .|.::...|:....|:..:       |......:.
pombe   641 GFR-----PKDNKDKESGGYNKRNSKIDLKKSFSKRFHWKRDSPHMSST-------PSISEEHLA 693

  Fly   363 DKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFR---SFILSRPSRRRLKQSGIYRERVFNC 424
            .:...:|   .|.|||     .|...:...:|.|.::   |..:.|..:.:..:|.::.....:.
pombe   694 SEEQEDF---VPAVGH-----CKLCGKYSNELRAHYQDCVSSTIDRQYQSKKSESPVWALNPDDF 750

  Fly   425 DLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAF-DEERVPDLGNPEM 487
            |.:...|   ..:|.::.||..|||:||: .:|:||.||.||.::::.... :|:.|.|     .
pombe   751 DQNRLTL---LRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLD-----P 807

  Fly   488 KQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKA--DEADERLRLMKETVLKLPPPHYRT 550
            .:||.||:|:.|.|.|.||||:.||..|..|:.|....:  |:.|..:.::|    .|||.|...
pombe   808 SEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIK----SLPPAHAEI 868

  Fly   551 LKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCH 615
            |:.:..||.:|:.:.....||.||||:|::|.|:|.|. .|..|..:.   |:.....:||.:.|
pombe   869 LQLIIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPD-NSRDVIDMT---VKNYSLAFLIDHVH 929

  Fly   616 NIF 618
            .:|
pombe   930 EVF 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_610002.1	PX_domain	168..274	CDD:470617	29/129 (22%)
		SH3_ARHGAP32_33	299..358	CDD:212769	12/62 (19%)
		RhoGAP_CdGAP	420..613	CDD:239849	64/196 (33%)
rga4	NP_595756.1	LIM	24..78	CDD:259829
		CENP-H	543..>606	CDD:461756	18/63 (29%)
		RhoGAP	759..928	CDD:214618	62/181 (34%)