DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and Arhgap22

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_006519017.1	Gene:	Arhgap22 / 239027	MGIID:	2443418	Length:	738	Species:	Mus musculus

Alignment Length:	758	Identity:	172/758 - (22%)
Similarity:	280/758 - (36%)	Gaps:	177/758 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 RRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHL 343
            |...|..||..|:...|.|....|                           |.....|..|:..:
Mouse    39 RSKSLVMGEQSRSPGRPLVPHKLG---------------------------PVLKAGWLRKQRSI 76

  Fly   344 QKSLYEVGFF----------------PQSCVATIGDKVPRNFPMPAPLVGHL-DASPTKPVLRKH 391
            .|:..:..|.                ||..::..|.:|....|.|.....|| :.:|.....|:
Mouse    77 MKNWQQRWFVLRGDQLFYYKDKDESKPQGFISLQGTQVTELLPDPEDPGKHLFEITPGGATERE- 140

  Fly   392 GKLIAFFRSFILSRPSRRRLK------------------------------QSGIYRERVFNCDL 426
             |:.|...:.:|...|:|.::                              .:||:.:|:.  |.
Mouse   141 -KVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGRGTSRSSHVHPVKPLSAGIFGQRLE--DT 202

  Fly   427 SEHLLNSGQDI-PMVLRSCAEFIENYGVI-DGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQ 489
            ..|....|..: |:::..|.:||...|:. :|::|:.|..:.::.|:.:||....|..   :...
Mouse   203 VHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLF---DSTT 264

  Fly   490 DIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQ-VKADEADERLRLMKETVLKLPPPHYRTLKY 553
            |:|.|:||||:|.||||.|:..:..|::|:...| :..||.:..:.|.|: |..||..:|..|:|
Mouse   265 DVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQ-VSNLPQANYNLLRY 328

  Fly   554 LAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIF 618
            :.:.|.:|..|.....|:.:|||.|:.||:|| |.:|. .|..:.|..:...:...|||....:|
Mouse   329 ICKFLDEVQAHSDVNKMSVQNLATVFGPNILR-PQIED-PVTIMEGTSLVQHLMTVLIRKHGQLF 391

  Fly   619 DA--LDDHPARHSMVASATAAAANAAGGE--------LRLESLTDCESLLVEQREQDQSLGVVER 673
            .|  |::..:.|..|...:........||        .|..|| |..:..|..|.....||....
Mouse   392 AATSLEEPASPHGTVEWGSEEVTRDHRGEPGSPGLPTHRTSSL-DGPAAAVLSRTSPPRLGSQTG 455

  Fly   674 PKSLSTGGAKLISL----EEAQERHSRVEG-ADLKQSLPISMLTSASS---NAASNIGSYIEVGG 730
            |.:.|. |.|:.:|    ...:::.||.|. ..:..||.:.:::|..:   |..|::.|:.....
Mouse   456 PAATSP-GKKMHTLPVWKSSFRQQGSRSESPKGVNSSLEVPIISSGGNWLINGLSSLRSHRRASS 519

  Fly   731 GPSSLPDKYHTVLSAPR--SWQKRKPDK---------TPSWKSIFSRSQRQGNPDPGQKITTDVK 784
            |     |:.....||.|  ::....|..         :.|| |:.|.|:.           ..|.
Mouse   520 G-----DRLKDTGSAQRLSTYDNVPPSSQFSSTASVASTSW-SVASSSRE-----------ASVS 567

  Fly   785 DSVASRVSFVQA-SHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSR 848
            ...|.|.|...| |..|....|.....|.|.|      ..:.|   ||   .:|:|. ..||...
Mouse   568 SCTACRASNSSACSSLHTEWALEPSPLPSSSE------GHQSP---DL---GHSLDE-PCVGSGS 619

  Fly   849 SVSHDSYFDLLQSPQRGHMTTCPS--RELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPP 911
            |..:|.     .||.:.|:..|.:  .:::||.....::..|.:     .||.|.
Mouse   620 SEPNDP-----GSPTQAHVRRCRALQGQVAELRAELCQQRTEYK-----RSLKSI---------- 664

  Fly   912 ASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSAR 954
            ..|||..|...:|.|:      .::...||...|.:...:|.|
Mouse   665 EEGSADLRKQMSRLEE------ELDQERKKYAMLEIKLRNSER 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769	8/74 (11%)
		RhoGAP_CdGAP	420..613	CDD:239849	60/195 (31%)
		FliJ	1322..1457	CDD:304890
Arhgap22	XP_006519017.1	PH-like	62..177	CDD:388408	21/143 (15%)
		RhoGAP_ARHGAP22_24_25	193..391	CDD:239855	63/205 (31%)
		Macoilin	<529..>719	CDD:370635	49/224 (22%)
		HCR	<638..719	CDD:284517	17/85 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910