DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Arhgap33

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001276611.1	Gene:	Arhgap33 / 233071	MGIID:	2673998	Length:	1305	Species:	Mus musculus

Alignment Length:	1362	Identity:	418/1362 - (30%)
Similarity:	579/1362 - (42%)	Gaps:	390/1362 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QISNASTESSCSPPIQGAVPP----------PKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQ 144
            |...|.:..|...|.:|:|.|          .||.:.     |::....||:|.:|||||||.|.
Mouse    23 QTLRARSTDSLDGPGEGSVQPVPTTGGPGTKGKPGKR-----LSAPRGPFPRLADCAHFHYENVD 82

  Fly   145 LGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENM 209
            .|.:.:.|   ..|..|.|::.::               |..:.:...|..|..|.|  ||:::.
Mouse    83 FGHIQLLL---SPEREGPSLSGEN---------------ELVFGVQVTCQGRSWPVL--RSYDDF 127

  Fly   210 QLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYA-------VAKYLERFSKIASDSLTCGT 267
            :.||..||||::||:.|.|       .|||...:...|       :.:|||..|.:...:|.||.
Mouse   128 RSLDAHLHRCIFDRRFSCL-------PELPPPPEGTRAAQMLVPLLLQYLETLSGLVDSNLNCGP 185

  Fly   268 ILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAE 332
            :|||::|||.||||.|::   :.::|.|||.||:.|:||.||||||::.||||::||||||...:
Mouse   186 VLTWMELDNHGRRLLLSE---EASLNIPAVAAAHVVKRYTAQAPDELSFEVGDIVSVIDMPPTED 247

  Fly   333 SIWWRGKKSHLQKSLYEVGFFPQSCVATI------GDKVPRNFPM---PAPLVGHLDASPTKPVL 388
            ..|||||:.      ::|||||..||...      |.|...:.|:   |||   ...:|.|..|.
Mouse   248 RSWWRGKRG------FQVGFFPSECVELFTERPGPGLKADADSPLCGIPAP---QGISSLTSAVP 303

  Fly   389 RKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV 453
            |..|||....|:|:.|||||:||:|.||.|:|||.|||.|||.|||||:|.|||.|:||||.:||
Mouse   304 RPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV 368

  Fly   454 IDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNF 518
            :||||||||::|||||||..||.||:|:|..|...||||:||||.|:|||||||||.|||||..|
Mouse   369 VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKF 433

  Fly   519 VEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNL 583
            .||:.|..:|  |||..:.:.:.:|||||||||:||..||.::::|...|.|..:||||||||||
Mouse   434 SEAMSVPGEE--ERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNL 496

  Fly   584 LRSPALES---GGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGE 645
            |||..|||   ||.||.|.|.||:||.|:|:.:...:|.            .:.|:|..:.||
Mouse   497 LRSMELESVGLGGAAAFREVRVQSVVVEFLLTHVEVLFS------------DTFTSAGLDPAG-- 547

  Fly   646 LRLESLTDCESLLVEQREQDQSLGVVERPKSL--STGGAKLISLEEAQERHSRVEGADLKQSLPI 708
                   .|               ::.|||||  |:...:|::|||||   :|.:|.....:.|.
Mouse   548 -------RC---------------LLPRPKSLAGSSPSTRLLTLEEAQ---ARTQGRLGTPTEPT 587

  Fly   709 SMLTSAS--------------SNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSW--QKRKPDKT 757
            :..|.||              ....|:..::..:|.|| |:|.|      .|..|  ..|.|.:
Mouse   588 TPKTPASPVERRKRERAEKQRKPGGSSWKTFFALGRGP-SIPRK------KPLPWLGGSRAPPQ- 644

  Fly   758 PSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSN 822
            ||          ...||.....:...::|::|:.|.......|..:      :|.|    .:.:.
Mouse   645 PS----------GSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLR------RPHS----SSDAF 689

  Fly   823 ERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRG---HMTTC-----------PSR 873
            ...|.|...|...:|..|..:...|.|.|..|...|  .|..|   |.|:.           |.|
Mouse   690 PVGPAPAGSCESLSSSSSSSSSSSSSSSSESSAGGL--GPLSGSPSHRTSAWLDDGDDLDFSPPR 752

  Fly   874 ELSEL-GLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNP 937
            .|..| ||:||     ...|..|......|.......||||.||..  .||.|:..|..    .|
Mouse   753 CLEGLRGLDFD-----PLTFRCSSPTPGDPAPPASPAPPASASAFP--PRATPQALSPH----GP 806

  Fly   938 SPKKQPRLNLLSPSSARTMPPPP---LSAPGTASSSC---------------GHESGGAENCCKR 984
            :....|....:|...|.::||..   |.|.||.:|:.               |.|:..::.|  :
Mouse   807 TKPASPTALDISEPLAVSVPPAVLELLGAGGTPASATPTPALSPHLIPLLLRGAEAQLSDTC--Q 869

  Fly   985 YKLEDQLCDIQFIDCGTPENVPTTQQQFASVE----------------VHPPPK-PAR------- 1025
            .::..:|...:    |.|     .||....::                ..|||| |||
Mouse   870 QEISSKLAPTR----GAP-----GQQSPGGMDSPLLPPPLPLLRPGGAPPPPPKNPARLMALALA 925

  Fly  1026 --------------------ANQSPISSS-----NGASVGSSSSSTRYSYPSVQLGAKRKEQQDA 1065
                                |..||...|     .|..||:|.|...  .||:
Mouse   926 ERAQQVAEQQSQQEQGGTPPAPHSPFRRSLSLEVGGEPVGTSGSGIH--PPSL------------ 976

  Fly  1066 KERFSYQGTFTQ------PGQKQESS---APRPVHSTNNGATLRKPRVEPVEDGQIKLHV----- 1116
                ::.|.:..      |.|:.:.|   :.||:     |.:.|.||    ...|:..|:
Mouse   977 ----AHPGAWAPGPPPYLPRQQSDGSLVRSQRPL-----GTSRRSPR----GPSQVSAHLRASGA 1028

  Fly  1117 --PTPTTPARSPRYSLLLCDTES-SDNSSAVNTPQYDMEPLMLTSAMSGVS-------------- 1164
              ..|...|:||      |...| ..|.|..:||:..:.|.:      ||.
Mouse  1029 YRDAPEMAAQSP------CSVPSQGSNPSFFSTPRECLPPFL------GVPKQGLYSLGPPSFPP 1081

  Fly  1165 -----------GVSSNVQQQQLL---LGVDASSSYLG-----------------SSHESLGQNIN 1198
                       |..|.:.:.:.|   :||...:||.|                 :|:..|||:..
Mouse  1082 SSPAPVWRNSLGAPSALDRGENLYYEIGVGEGTSYSGPSRSWSPFRSMPPDRHNASYGMLGQSPP 1146

  Fly  1199 NH----------------------HDAEQRDMNALKRELSLDLN-PLQPRLPQPANRAATLP 1237
            .|                      |...||......|...|.:| .|.||.|.||:.:::.|
Mouse  1147 LHRSPDFLLSYPPPPSCFPPEHLTHSVSQRLARRPTRPEPLYVNLALGPRGPSPASSSSSSP 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	31/112 (28%)
		SH3_ARHGAP32_33	299..358	CDD:212769	31/58 (53%)
		RhoGAP_CdGAP	420..613	CDD:239849	122/195 (63%)
		FliJ	1322..1457	CDD:304890
Arhgap33	NP_001276611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		10/45 (22%)
		PX_domain	80..192	CDD:383026	37/138 (27%)
		SH3_ARHGAP32_33	214..267	CDD:212769	31/58 (53%)
		RhoGAP_CdGAP	335..529	CDD:239849	122/195 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..818		64/283 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..1054		44/233 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1115..1305		21/94 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836271
Domainoid	1	1.000	194	1.000	Domainoid score	I3163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		otm43987
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870