DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and Arhgap25

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001032816.1	Gene:	Arhgap25 / 232201	MGIID:	2443687	Length:	648	Species:	Mus musculus

Alignment Length:	674	Identity:	154/674 - (22%)
Similarity:	252/674 - (37%)	Gaps:	196/674 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 PSPAE---SIWWRGKKSHLQKS------------LY----EVGFFPQSCVATIGDKVPRNFPMPA 373
            |:|.|   .:.|..|:..:.|:            ||    |....||.|:.           :|.
Mouse    41 PNPLERPIKVGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDSKPQGCMY-----------LPG 94

  Fly   374 PLVGHLDASPTKPVLRKHGKLIAFFR--------------SFILSRPSRRRLKQ--------SGI 416
            ..|..:..:|     .:.||.:  |.              |::|...|:..:::        :|.
Mouse    95 STVKEIATNP-----EEAGKFV--FEVIPASSDQNRIGQDSYVLMASSQVEMEEWVKFLRRVAGT 152

  Fly   417 YRERVFNCDLSE----------HLLNSGQDIPMVLRSCAEFIENYGVI-DGIYRLSGITSNIQRL 470
            ....||...|.|          ||      :|:::..|||||..:||. :||:||.|..:.:::|
Mouse   153 PSGAVFGQRLDETVAYEQKFGPHL------VPILVEKCAEFILEHGVSEEGIFRLPGQDNLVKQL 211

  Fly   471 RRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQ-VKADEADERLR 534
            |.|||....|..   :...|:|.|:||||:|.|:||.|:..:..|:.|:...| :.||||..:..
Mouse   212 RDAFDAGERPSF---DRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLMNADEAKAQQE 273

  Fly   535 LMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRS----PALESGGVA 595
            |:|: :..||..:|..|.|:...|:::..:.....|:..|||.|...||:||    ||:
Mouse   274 LVKQ-LSTLPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAV------ 331

  Fly   596 ALRGV-GVQAVVTEYLIRNCHNIF-----------------------------DALDDHPARHSM 630
            .:||. .:|.|:| .:||:...:|                             ||.:|.|...:.
Mouse   332 IMRGTPQIQRVMT-MMIRDHEVLFPKSKDAPISPPAQKNDAKKAPVPRSSVGWDATEDPPLSRTD 395

  Fly   631 VASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERP-----------KSL------- 677
            ..|.||::.:|......|.|         :|.::|......|.|           ::|
Mouse   396 SFSNTASSPDATSPTGPLPS---------DQHQEDSGKAPRENPGDWKMQSRKRTQTLPNRKCFL 451

  Fly   678 -----STGGAKL----------ISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIE 727
                 .|..:||          .|..:|.|.|.|....||:. |.....||...|..::..|.
Mouse   452 TSAFQGTTSSKLEIFKNEFWSPSSEAKAGEGHRRTMSQDLRH-LSNDQRTSTYDNVPTSPQSQ-- 513

  Fly   728 VGGGPSSLPDKYHTVLSAPRSWQKRKP-DKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRV 791
              |.|:.       .||.|.|..||.. ..|.|.....|::..:.:.|..|:....::..:.::.
Mouse   514 --GNPAG-------ALSPPASDSKRDALVSTDSEMEAGSKNSGEDDLDSLQRTVQSLQKEIETQK 569

  Fly   792 SFVQASHAHASKELTKHDK-PKSIELLETTSNERDPKPMDLCIRSNSID-SLRTVGHSRS----- 849
            ...:....:..||  .:|. .|.:.|.|....||.        :..::: |||.|..||.
Mouse   570 QVYEEQIKNLEKE--NYDVWAKVVRLNEELERERK--------KFAALEISLRNVERSREDVEKR 624

  Fly   850 --VSHDSYFDLLQSPQRGHMTTCP 871
              |..:...:.::|.::....|.|
Mouse   625 NRVLEEEVKEFVKSMEKPKTKTDP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769	11/48 (23%)
		RhoGAP_CdGAP	420..613	CDD:239849	69/209 (33%)
		FliJ	1322..1457	CDD:304890
Arhgap25	NP_001032816.1	PH_RhoGap25-like	45..157	CDD:270083	20/129 (16%)
		PH	47..149	CDD:278594	18/119 (15%)
		RhoGAP_ARHGAP22_24_25	156..354	CDD:239855	70/214 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..559		43/223 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910