DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Arhgap30

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001005508.2	Gene:	Arhgap30 / 226652	MGIID:	2684948	Length:	1093	Species:	Mus musculus

Alignment Length:	1226	Identity:	291/1226 - (23%)
Similarity:	455/1226 - (37%)	Gaps:	377/1226 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 SRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLR 471
            ||::.|:.|..:||||.|||.|||.:|||::|.||||||||::.|||:||||||||::||||:||
Mouse     3 SRQKGKKKGSSKERVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQKLR 67

  Fly   472 RAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLM 536
            :.|:.||.|||......||||.||||.|.||||||:||.||:|||.|.||:.|:.:  .|||..:
Mouse    68 QEFETERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVAVQLE--PERLVKI 130

  Fly   537 KETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALES---GGVAALR 598
            .|.:.:||..:||||::|..||..::....:|.|..:|||||||||||||..:|:   .|.||..
Mouse   131 LEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFM 195

  Fly   599 GVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQRE 663
            .|.||::|.|:::.:...:|
Mouse   196 EVRVQSIVVEFILTHVDQLF--------------------------------------------- 215

  Fly   664 QDQSLGVVERPKSLSTGGAKLISLEEAQER--HSRVEGAD---LKQSLPISMLTSASSNAASNIG 723
                     |..|||.|    :.||...:.  .:|..|:.   :..|||.            ::.
Mouse   216 ---------RGDSLSAG----VDLESGWKSLPGARASGSSEDLMPTSLPY------------HLP 255

  Fly   724 SYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPD-KTPSWKSIFSRSQRQGNPDPGQKITTDVKDSV 787
            |.::.|.||..: ..|||::....  .|||.. |...|:|||:.. |.|:.
Mouse   256 SILQAGDGPPQI-RPYHTIIEIAE--HKRKGSLKVRKWRSIFNLG-RSGHE-------------- 302

  Fly   788 ASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSH 852
                              ||...|..:|..|..|::...:|      :.|:|||.....:.
Mouse   303 ------------------TKRKLPLRVEDREEKSSKGTLRP------AKSMDSLSAAAGAS---- 339

  Fly   853 DSYFDLLQSPQR--GHMTTCPSRELSE-LGLNF--DREEPEMRIFSESESLVSSPRVGKENVPPA 912
                   ..|:.  |..::.||..:.| |..|.  ..:|||......:.|...:||.|:..|...
Mouse   340 -------DEPEGLVGSSSSQPSSLMPESLESNSMEGEQEPEAEAPGSANSEPGTPRAGRSAVRAL 397

  Fly   913 SGSATRRIMRARPED--------FSSQTNSVNPS----------------PKKQPRLN-LLSP-- 950
            ..|...|.......|        ..:...||.|:                |..|||.: .|.|
Mouse   398 GSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLVRLTRGLECPALQPRPSPALGPGP 462

  Fly   951 ----SSARTMPPP-PLSAPGTASSSCGHESGGAENCCKRYKLEDQLC-DIQ----FIDCGTPENV 1005
                |.||::|.| ..|:|...:.:                |||.|. ::|    |:     |::
Mouse   463 PDEKSEARSVPGPLDDSSPAAMTPA----------------LEDSLSQEVQDSFSFL-----EDL 506

  Fly  1006 PTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKE--------- 1061
            .:::.::..||..   :.|:|..:..:.:...|:|.......|....:::|.:.:|
Mouse   507 SSSEPEWVGVEER---EVAKAEAAGAAGAAAFSLGEDDPGMGYLEELLRVGPQVEEFSVEPPLDD 568

  Fly  1062 ----------------------QQDAKERFSYQGTFTQPGQKQESSAPRPVHSTNNGATLRKP-- 1102
                                  ..|.:|.:..:...:..........|:|::....|:...:.
Mouse   569 LSLDDTQYVLAPNCCSLDSAVSTPDVEEDYGEEVFLSAYDDLSPLLGPKPINWEGVGSLEEEAAG 633

  Fly  1103 --RVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDN-SSAVNTPQYDMEPLMLTSAMSGVS 1164
              :..|.:|.:.:....|.......||        .:||| ..|..||:.:||     :..:...
Mouse   634 CGKQPPTQDEEEQACSETRQEKEAKPR--------STSDNREEAEATPETEME-----AGKADAE 685

  Fly  1165 GVSSNVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQP 1229
            |..:...|:.:       .|:...|.|.|.....|   :|.|::.::|....::
Mouse   686 GGEAERSQKVM-------DSFKEGSREELEAKEEN---SEGREVESIKETKDVE----------- 729

  Fly  1230 ANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPV 1294
              :....|.||:                                   :|::.........:.:||
Mouse   730 --KIIGEPGKDE-----------------------------------EREIGREEGAEKGDDTPV 757

  Fly  1295 YEDFEQTPVKMVPSPIKSTISITYKSPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLH 1359
            ..|.:                     ||...:...:||.:::....:|..| .|.|.|   :.|.
Mouse   758 DSDMD---------------------PEHVFQEDLVLEESWEVVHKHEAEK-GRESET---KELR 797

  Fly  1360 ERSSLKQIAEEEQH---DGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYE--NIE 1419
            .:|.||. .|::.|   .|...:..:..:.:...||:..|.|.:..:...|..:...|.|  .:|
Mouse   798 RKSDLKS-REDQGHSEDSGSPEEGDDRKEGVFSKEQKSIDVETEVMRGVGDHLEEGALSEGPGVE 861

  Fly  1420 LRKPKTVYE-NLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHE-QSSPSKSPTFSVKELANK 1482
            |.:..:..| |.:..|||     |.|        ...|.|:.||.| |.:|.....:
Mouse   862 LLRVDSTEEINEQTSEMK-----QAP--------LQPSEPEGMEAEGQLNPETCDLY-------- 905

  Fly  1483 FESSPVEQLPNFDFSVRGGSMKKPNEL-------SVPKTMPAPVPLKKLNSSAQKI 1531
              |.|..       |..|..|:..:.|       |||...|.|...|..::...||
Mouse   906 --SCPCG-------SAGGVGMRLASTLVQVRQVRSVPVVPPKPQFAKMPSAMCSKI 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769
		RhoGAP_CdGAP	420..613	CDD:239849	107/195 (55%)
		FliJ	1322..1457	CDD:304890	31/140 (22%)
Arhgap30	NP_001005508.2	RhoGAP_CdGAP	16..210	CDD:239849	107/195 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..397		24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..840		53/322 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..893		10/35 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1036..1068
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836270
Domainoid	1	1.000	194	1.000	Domainoid score	I3163
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15729
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.800