DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and Arhgap9

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001272714.1	Gene:	Arhgap9 / 216445	MGIID:	2143764	Length:	648	Species:	Mus musculus

Alignment Length:	654	Identity:	158/654 - (24%)
Similarity:	260/654 - (39%)	Gaps:	156/654 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 APPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPP 110
            |||....:..|||.::.:......|||:    :|.....:..| ::.:.|.|....|. :..|..
Mouse    69 APPSSRPIFVPAAYMTEESICCHNPADT----TYNSSLWTPGT-KLYHGSLEELYLPQ-EPQVAS 127

  Fly   111 PKPSRH-----MAVQPLNSKSCRFPKLE----ECAHFHYERVQLGPLSVQLLDDKSEHMGSSIAS 166
            .:|..|     .:|...|.|:|.....:    |.:|:....|.:.|.|::..:..:.. .|::..
Mouse   128 GQPLHHPHKMCKSVSTGNVKACSLKSFKEGPGERSHWWMTEVAVKPGSMEQTETLTRD-SSALQP 191

  Fly   167 QSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNM 231
            |..   |....|.|.|....|..:..     :|..::......||||:. |  |.:|  |||.||
Mouse   192 QEW---LDPQGLPSLSQSVPWLALSE-----QPGALRPCSALPQLLDDP-H--VEER--SGLLNM 243

  Fly   232 EELA---AELPSESDVEYAVAK------YLERFSKIASDSLTCGTILTWLQLDNK---------- 277
            .::|   .:|.......:.|..      |.||..:.||       :..|.:..::
Mouse   244 TKIAQGGRKLRKNWGPAWVVLTGSSLVFYRERPPQSAS-------LQGWARAGSRPESSVDLRGA 301

  Fly   278 ----GRRLP------------------LADGETQ-----RTINTPAVGAAYGVRRYQAQAPDEIN 315
                ||:|.                  .:|.||:     |.:.|.       :.|...:.|.|:.
Mouse   302 ALASGRQLSSRRNVLHIRTVPGHEFLLQSDEETELRDWHRALRTV-------IERLDRENPLELR 359

  Fly   316 I------EVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQS--CVATIGDKVPRNFPMP 372
            :      |:.::.:..|....:|.:         .|||..:|....|  |
Mouse   360 LSGSGPAELAELSAGEDDELESEPV---------SKSLMRLGSRRTSSRC--------------- 400

  Fly   373 APLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDI 437
                    |..|....|...||    :..|..||:.:.|::.|::|::||.|.|.......|..:
Mouse   401 --------AEGTDQKNRVRNKL----KRLIAKRPTLQSLQERGLFRDQVFGCQLESLCQREGDTV 453

  Fly   438 PMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAFDEERV---------PDLGNPEMK---- 488
            |..:|.|.|.::..|: :|||||:||..:.:|:||...|.||.         |:....|.|
Mouse   454 PSFVRLCVEAVDKKGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYMFPEQAGQEGKLDLD 518

  Fly   489 ----QDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYR 549
                .|||.|:..||::|||||.||....|..:|.:|:::  .|.::.|..:::.:..||.|::.
Mouse   519 SAEWDDIHVVTGALKLFFRELPQPLVPALLLPDFRDALEL--SEPEQCLSKIQKLIDSLPRPNHD 581

  Fly   550 TLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNC 614
            ||||:.|||.:|..|..:..||..||.||:.|.|.| |..|:..:||  .|.....:.:.::.|.
Mouse   582 TLKYILEHLCRVIAHSDKNRMTAHNLGIVFGPTLFR-PEQEASDMAA--HVFYPGQLVQLMLNNF 643

  Fly   615 HNIF 618
            .::|
Mouse   644 ASLF 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	27/114 (24%)
		SH3_ARHGAP32_33	299..358	CDD:212769	11/66 (17%)
		RhoGAP_CdGAP	420..613	CDD:239849	70/210 (33%)
		FliJ	1322..1457	CDD:304890
Arhgap9	NP_001272714.1	SH3	26..82	CDD:302595	5/12 (42%)
		PH_ARHGAP9-like	236..349	CDD:270053	23/128 (18%)
		PH	250..348	CDD:278594	16/111 (14%)
		ASCH	<346..432	CDD:294653	21/128 (16%)
		RhoGAP_ARHGAP27_15_12_9	438..642	CDD:239868	69/208 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940