DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and rrc-1

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001024683.1	Gene:	rrc-1 / 181195	WormBaseID:	WBGene00009800	Length:	759	Species:	Caenorhabditis elegans

Alignment Length:	883	Identity:	242/883 - (27%)
Similarity:	394/883 - (44%)	Gaps:	166/883 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 IQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLL-----DDKSEHMGSS 163
            |:.:..|..|....|.:  |.:|.|..:|.:|.||||..|:|||:.|.::     ::.:|.:...
Worm     4 IEESFAPLSPKSPFARR--NGRSLRIQRLVDCQHFHYSSVELGPVRVAIIAINADENATERIKMR 66

  Fly   164 IASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGL 228
            :.|:|                :.|             |::||.|:..:.|..|||||::|:.|
Worm    67 VESES----------------NSW-------------LVERSREDWAVFDRQLHRCVFERRHS-- 100

  Fly   229 RNMEELAAELPSE-SDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTI 292
             .::||...:..| :..|..:.||.||.|::....:||..:|.:|::|::|.....|:   :.:|
Worm   101 -RLDELFPLIHLETAKFEEVLVKYTERLSELTGSIITCYPVLKFLEIDSRGGHFEPAE---ETSI 161

  Fly   293 NTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDM--PSPAESIWWRGKKSHLQKSL-------- 347
            |.||:.||...:.::.....::.:.|||::|:.:|  .||:|..:|:.|.:...:.:
Worm   162 NVPAIAAAVVTKDFEPTESSQLRLRVGDIVSITEMSTASPSEQTFWKAKLTISNQKIVDPQNARL 226

  Fly   348 -YEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRL 411
             :|:|:||:.||..|.||     .:|.||.....|| |:...|   .:...||:        ||
Worm   227 GFEIGYFPRDCVMLIDDK-----RLPNPLNNEQKAS-TRNARR---YMTTMFRN--------RR- 273

  Fly   412 KQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDE 476
                  ||.:|..:|::..:.:|:.:|:::..|...||:.|::.||||..||.|||||||..||.
Worm   274 ------REPIFGLELTDLYMRTGKKVPVIVEKCCASIEDQGIVTGIYRQCGIQSNIQRLRAKFDS 332

  Fly   477 ERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVL 541
            ...||| :...::||::||||||.|||:|||||.|||.|...:||.: |.|...|::..::.::.
Worm   333 GAEPDL-HEFGQRDIYSVSSLLKQYFRQLPNPLFTYQAYPKLIEAFE-KEDSLSEKVESLRFSLE 395

  Fly   542 KLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLR-SPALESGGVAALRGVGVQAV 605
            .:|..||||.|:|.|||.::.:....|.||.|||||||:|||.| .|.|.......|.|:.|...
Worm   396 TMPEAHYRTAKFLMEHLTRLCKSKSLTDMTSKNLAIVWSPNLFRPPPTLNGADTHLLSGLNVHTA 460

  Fly   606 VTEYLIRNCHNIF-DALDDHPARHSMVA-SATAAAANAAGGELRLESLTDCESLLVEQREQDQSL 668
            :.::.|.|..::| :.:|:..::.:.|. |.|..:.:|...::|.||.:......  :.:..:..
Worm   461 ICDFFIENSESLFVNDIDEEQSKCTSVENSFTTISKSATMSDMRSESESKWPRFF--RGKSVEGF 523

  Fly   669 GVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAA---SNIGSYIEVGG 730
            ....|.:..|||........|.:.|.....              |.|::||   |...|:|::
Worm   524 WKFNRKQQTSTGELCGSPTSEVKWRSRSTR--------------SHSTDAAFQSSRTDSFIQL-- 572

  Fly   731 GPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIF---SRSQR-QGNPDPGQKITTDVKDSVASRV 791
                    .||.:...|...:           ||   :||.| ...|.|..:         ..|.
Worm   573 --------MHTGMDQIREGMR-----------IFRARARSMRPTSRPPPSPR---------TRRA 609

  Fly   792 SFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSV--SHDS 854
            .|...|..:..| |.:.|....|. |.||.....|:|      .|::|..:.:..:.||  |.|.
Worm   610 RFSNGSSNNVQK-LNESDIQHEIP-LATTEPSITPEP------KNTVDPHQIMTRTISVNDSDDQ 666

  Fly   855 YFD---LLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSA 916
            .|:   |.:..:|..|....::|  .:....:|..|.....|:|...:.......:||.| ||:.
Worm   667 SFEENGLREMRERKVMFKAATQE--HVATFHERSSPVEEWSSDSRESLHLEMSRYDNVSP-SGTI 728

  Fly   917 TRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSAR 954
            ||              |...|.....|...:|...|:|
Worm   729 TR--------------NQREPITNLSPAAQMLFFESSR 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	27/106 (25%)
		SH3_ARHGAP32_33	299..358	CDD:212769	16/69 (23%)
		RhoGAP_CdGAP	420..613	CDD:239849	81/193 (42%)
		FliJ	1322..1457	CDD:304890
rrc-1	NP_001024683.1	PX_domain	41..146	CDD:295365	34/136 (25%)
		SH3	168..238	CDD:302595	16/69 (23%)
		RhoGAP	276..466	CDD:295372	80/191 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167408
Domainoid	1	1.000	145	1.000	Domainoid score	I2829
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		oto18485
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	LDO	PTHR15729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870