Protein Alignment CdGAPr and pac-1

DIOPT Version :9

• Sequence 1: NP_001260600.1
• Gene: CdGAPr / 35267
• FlyBaseID: FBgn0032821
• Length: 1843
• Species: Drosophila melanogaster
• Sequence 2: NP_498877.4
• Gene: pac-1 / 176201
• WormBaseID: WBGene00015418
• Length: 1605
• Species: Caenorhabditis elegans
• Alignment Length: 1360
• Identity: 266/1360 - (19%)
• Similarity: 454/1360 - (33%)
• Gaps: 431/1360 - (31%)

  Fly     2 SDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKD--------AQAPPLQFEMDAPAA 58
            |...|.|.:.:..|.|:|:|.||.:........:.::|.|.:        .:|.|..:.:...|:
 Worm   422 SSTSSISTSGEASSTAVAAAAAGSVAATTSRQTSSNSSVDSNHNEAMKMIRRARPKSYVLATSAS 486

  Fly    59 AISAQLNFKIVPADSLPGLSY------QDMFASMNTSQIS-----------NASTESSCSPPIQG 106
            .....|:..|:..:....:|:      :::.:|:..|.||           ..:|.|:.......
 Worm   487 MNEDVLSSSIIANEQSSSISHDTTTSGRELPSSLMGSTISMEMRSGGASSATTTTTSNSGQQTSR 551

  Fly   107 AVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSI--ASQSL 169
            ::..|.|       |...:..||     .|.|:         |.:..|...||..|.:  :..||
 Worm   552 SLNAPHP-------PATHRLQRF-----IALFN---------SSKTSDGSGEHKKSRMKRSRTSL 595

  Fly   170 GGD---LPHSSL-RSFSPESCWFIIRVCPQRCEPFLIKRSFEN------MQLLDEMLHRCV---- 220
            ...   ||.:.| |.......|.      :..|..|.|....|      ..|....|:.||
 Worm   596 PASRFALPGTILQRDGVARQTWV------KHQEIALGKSGKRNNWEDRWAVLCRRSLYLCVESPA 654

  Fly   221 -------------------------YDRKISGL-----------RNMEELAAELPSESDVEYAVA 249
                                     ||...|..           :|..|...||.:||:    :.
 Worm   655 YTTEKTIELGSHTRVDVCNAIVDIAYDWLSSSFSKQRHVVRIVTQNRSEHLIELNTESE----ML 715

  Fly   250 KYLERFSKIASDSLTCGTILTWLQLDNKGRR------------------LPLADGETQRTINTPA 296
            .::......:.|.:..|:.:...:|...||.                  ..||.........:..
 Worm   716 SWISVLQSSSEDGIATGSSVDENELSTTGRHNNNAVSNSSALLHNSQSIASLASSSCSTATTSEF 780

  Fly   297 VGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATI 361
            :.:.:.:::.|.|..::.:.:..:.:|.             |..|||..|....|....:...|.
 Worm   781 LNSQHTLQQQQQQQTNQKHQQTVNELSA-------------GIVSHLPTSKSFGGLSTTASSTTE 832

  Fly   362 GDK--------VPRNFPMPAPLVG-HLDASPTKPVLRKHGKLIA-----FFRSFILSRPSR---- 408
            ..|        :.:|..:.:|... .::..|:  .:....:.:|     |......:.|||
 Worm   833 NAKNRLIMHRYIAKNSQLQSPTANKKMETDPS--TVPSSSQTMATTSSSFHHHSSQAGPSRDIEN 895

  Fly   409 --------------RRLKQSGIYRE----------------------------RVFNCDLSEHLL 431
                          |:.|:|...::                            |:.:|.     .
 Worm   896 GEAPTATATTPKSGRKWKKSKAAKQGSGGGSSGSSSGSQQQGAAGAPQPVLGVRIADCP-----T 955

  Fly   432 NSGQD-IPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLR-----RAFDE---ERVPDLGNPE 486
            .|.:| :||::::|...||.||: ..||||:.|.|:.:..|:     |.||.   .:|..| :|.
 Worm   956 GSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESL-DPR 1019

  Fly   487 MKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTL 551
            .: |::.|||||||:.|:||.||.|.:||..|::|.::....  .||..::..:.|||.|||.||
 Worm  1020 WR-DVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHH--NRLHKLRNLLRKLPRPHYDTL 1081

  Fly   552 KYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHN 616
            ::|..||.::::|.....|..:|||:::.|:::| |: :......:..:..|..:.|.||.  :|
 Worm  1082 RFLIVHLSEITKHSDVNKMECRNLALMFGPSIVR-PS-DDNMATMVTHMSDQCKIIETLIH--YN 1142

  Fly   617 IF---------DAL-DDHPARHSM----------VASATAAAANAAGGELRLESLTDCESLLVEQ 661
            ::         ||: :.|||....          |.:..:||           |..|..: |:.:
 Worm  1143 LWMFDESSTTEDAVPEQHPADGQNPLEPGGYGVGVPTGVSAA-----------SFNDMHN-LIRK 1195

  Fly   662 REQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYI 726
            ..:||:..::...|     |.|   ::....|:||.:.:  |..|.|.....|:.|
 Worm  1196 ANEDQAAAMMNEGK-----GQK---IKNMLRRNSRRDKS--KSKLKIESTAPAAVN--------- 1241

  Fly   727 EVGGGPSSLPDKYHTVLSAPRSWQKRKPDKT--PSWKSIFSRSQRQGNPDPGQKITTDVKDSVAS 789
                               ||.|.:..|..|  .|.:|.|..:.::          .|:...:.|
 Worm  1242 -------------------PRGWTQPTPSNTSAASVESAFCGNYQE----------RDIDAEIES 1277

  Fly   790 R--VSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSH 852
            |  ||....|.:......|:.|:..|:|                    :|:.||.....:..:..
 Worm  1278 RQTVSPQMTSGSADGASSTRLDQSPSLE--------------------SSLGSLPDTSRTEPILG 1322

  Fly   853 DSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSAT 917
            .|.:|                         |.|..|.......|.:.|:.|:.......|:.:||
 Worm  1323 SSGYD-------------------------DDEAKEAARRKRQEEMYSARRIFIAGAAGAAAAAT 1362

  Fly   918 RRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSS---ARTMPPPPLSAPGTASSSCGHE----- 974
            ......:....:...:|.:......|...:||..:   .|.|          ......|:
 Worm  1363 TTADAEKAAIDALANHSQHLHLASSPAFEVLSEETREKIRRM----------QKKQSWHDTKELR 1417

  Fly   975 SGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASV 1039
            ||   ...|.|.....|.|.  :.|  ..:..||..  |.:..:||...|.|:| |.|||:.||.
 Worm  1418 SG---ELLKTYSPTKDLTDA--LSC--TSDYSTTSS--APLSTNPPLAVACADQ-PNSSSDYASS 1472

  Fly  1040 GSS-----SSSTRYSYPS------VQLGAKRKEQQDAKERFSYQGTFTQPGQKQE---------S 1084
            ..|     .|::..|.||      .||.|.           |..|...||..:.:         |
 Worm  1473 DPSPCARNPSTSPASRPSNLAISPAQLHAT-----------SSSGQSHQPMSRSQKIRLRTKLGS 1526

  Fly  1085 SAPRPVHSTNNGATLRKPRV------------------EPVEDGQIKLHVPTPTTPARSP 1126
            ..|...|:.::..||::.|:                  :.|.|.: |.|...|..||.:|
 Worm  1527 RDPARRHTLSDVDTLKEGRLDKLARWFGIRKSSPDVSRDEVSDDE-KNHQEAPPLPAAAP 1585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	26/155 (17%)
		SH3_ARHGAP32_33	299..358	CDD:212769	9/58 (16%)
		RhoGAP_CdGAP	420..613	CDD:239849	67/202 (33%)
		FliJ	1322..1457	CDD:304890
pac-1	NP_498877.4	PH_ARHGAP21-like	613..728	CDD:269955	18/124 (15%)
		PH	617..726	CDD:278594	18/118 (15%)
		RhoGAP_ARHGAP21	945..1146	CDD:239860	68/213 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940