DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and tag-325

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001309440.1	Gene:	tag-325 / 175636	WormBaseID:	WBGene00008006	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	160/694 - (23%)
Similarity:	257/694 - (37%)	Gaps:	188/694 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDKVSTSLAAQL-HSHALASAEAGGIGGVNGGPIACHASTDKDAQ--APPLQFEMDAPAAAISAQ 63
            |.|.||:....: |.:|..|:.....      |.|.:..|||.|.  .||...|......||..:
Worm   253 SRKASTASGVMMPHPYAHVSSFQSTF------PRAKNEDTDKLASYVIPPDANETSKTPTAIRVR 311

  Fly    64 LNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCR 128
                                 ..:.:.:.:.|.::.|:  :...||.|:      |.|..|.|
Worm   312 ---------------------RPSPTNLRSVSFQNKCT--VLKNVPMPQ------VLPTTSSS-- 345

  Fly   129 FPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVC 193
               .:....:|...    |....|::|.::...||...:..|.......:|:.
Worm   346 ---FDHHPQYHSNT----PDRPILMEDSADFTPSSRCEERRGSGDGREPVRTI------------ 391

  Fly   194 PQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRN-MEELAAELPSESDVEYAVAKYLERFSK 257
              ||..  ::|| ||    ||...:.|..:|...:.| |....|.|     :.|...|..|:..|
Worm   392 --RCGD--LERS-EN----DEPAEKVVKPKKREWITNYMYLTTAHL-----ILYKDQKSAEKHGK 442

  Fly   258 --IASDSL--TCGTILTWLQLDNKGRRLPLADGETQR------TINTPAVGAAYGVRRYQAQAPD 312
              .|...:  ..|..:||.| ||:.     ...:.||      ..||         ::|..:.|:
Worm   443 HYDAPQGVWDLRGASVTWYQ-DNRD-----VQKKKQRKYIQLELCNT---------KKYLLRGPN 492

  Fly   313 EINI--------EVGDMISVIDMPSP--------------AESIWWRGKKSHLQKSLYEVGF--- 352
            :...        ||     |..:|||              |.:..:.|....|..:|..:..
Worm   493 DTEAVEWYKSLEEV-----VAKLPSPGSSNQPMIDVTNGVARNPSYIGSTRPLSHALIPISRSMR 552

  Fly   353 -----FPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLK 412
                 ..||.:.|:...|..:.|.|:          .:.::.|       .|.|..:||:...||
Worm   553 RRDDPMSQSAIETVSTSVSTDEPRPS----------KETIIEK-------LRRFFRTRPTVESLK 600

  Fly   413 QSGIYR-ERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAFD 475
            :.|||: |.||...||....:....:|..:|...|.||:.|: .|||||:||..|.:|::|...|
Worm   601 EKGIYKPEPVFGSTLSAICQHENSLVPKFIRVITEVIESKGLETDGIYRVSGNLSAVQKIRCQAD 665

  Fly   476 EERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETV 540
            ::....|.:.|   |||.::..||::||||.:||....|:..:..|:|:  ..|..|.:..:|.:
Worm   666 QDNYKALVSEE---DIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQM--PNATTRFKKFEELL 725

  Fly   541 LKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLL--------------------- 584
            .:||..:..|||.|..||.:|:.|..:..|...|||||:.|.|.
Worm   726 SRLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLAIVFGPTLFHNGDGAVNLATKNKKAGKKAK 790

  Fly   585 -------RSPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDAL 621
                   ::..::|....|...: :|:.:.:||:.:. |.||.|
Worm   791 PSKKEETQATPVQSNSHLAFSMI-MQSQIVQYLLESA-NKFDIL 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	24/110 (22%)
		SH3_ARHGAP32_33	299..358	CDD:212769	14/88 (16%)
		RhoGAP_CdGAP	420..613	CDD:239849	63/221 (29%)
		FliJ	1322..1457	CDD:304890
tag-325	NP_001309440.1	WW	101..130	CDD:278809
		PH_ARHGAP9-like	391..509	CDD:270053	34/163 (21%)
		PH	407..508	CDD:278594	25/125 (20%)
		RhoGAP_ARHGAP27_15_12_9	611..825	CDD:239868	62/219 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940