Protein Alignment CdGAPr and ARHGAP33

DIOPT Version :9

• Sequence 1: NP_001260600.1
• Gene: CdGAPr / 35267
• FlyBaseID: FBgn0032821
• Length: 1843
• Species: Drosophila melanogaster
• Sequence 2: XP_006723062.1
• Gene: ARHGAP33 / 115703
• HGNCID: 23085
• Length: 1298
• Species: Homo sapiens
• Alignment Length: 1397
• Identity: 412/1397 - (29%)
• Similarity: 580/1397 - (41%)
• Gaps: 352/1397 - (25%)

  Fly    94 ASTESSCSPPIQGAVPP----------PKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPL 148
            |.:..|...|.:|:|.|          .||.:.     |::....||:|.:|||||||.|..|.:
Human     3 ARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKR-----LSAPRGPFPRLADCAHFHYENVDFGHI 62

  Fly   149 SVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLD 213
            .:.|..|:.   |.|::.::               |..:.:...|..|..|.|  ||:::.:.||
Human    63 QLLLSPDRE---GPSLSGEN---------------ELVFGVQVTCQGRSWPVL--RSYDDFRSLD 107

  Fly   214 EMLHRCVYDRKISGLRNMEELAAELPSESDVEYA-------VAKYLERFSKIASDSLTCGTILTW 271
            ..||||::||:.|.|       .|||...:...|       :.:|||..|.:...:|.||.:|||
Human   108 AHLHRCIFDRRFSCL-------PELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTW 165

  Fly   272 LQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWW 336
            ::|||.||||.|::   :.::|.|||.||:.::||.||||||::.||||::||||||...:..||
Human   166 MELDNHGRRLLLSE---EASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWW 227

  Fly   337 RGKKSHLQKSLYEVGFFPQSCV------------ATIGDKVPRNFPMPAPLVGHLDASPTKPVLR 389
            |||:.      ::|||||..||            |...|..|...|.|..:     :|.|..|.|
Human   228 RGKRG------FQVGFFPSECVELFTERPGPGLKAADADGPPCGIPAPQGI-----SSLTSAVPR 281

  Fly   390 KHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVI 454
            ..|||....|:|:.|||||:||:|.||.|:|||.|||.|||.|||||:|.|||.|:||||.:||:
Human   282 PRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVV 346

  Fly   455 DGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFV 519
            ||||||||::|||||||..||.||:|:|..|...||||:||||.|:|||||||||.|||||..|.
Human   347 DGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFS 411

  Fly   520 EAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLL 584
            ||:.|..:|  |||..:.:.:.:|||||||||:||..||.::::|...|.|..:|||||||||||
Human   412 EAMSVPGEE--ERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLL 474

  Fly   585 RSPALES---GGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGEL 646
            ||..|||   ||.||.|.|.||:||.|:|:.:...:|.            .:.|:|..:.||
Human   475 RSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFS------------DTFTSAGLDPAG--- 524

  Fly   647 RLESLTDCESLLVEQREQDQSLGVVERPKSL--STGGAKLISLEEAQERHSRVEGADLKQSLPIS 709
                  .|               ::.|||||  |....:|::|||||.|.....|...:.:.|.:
Human   525 ------RC---------------LLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKA 568

  Fly   710 MLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQ------ 768
            ..:.|....             |.|.|::..   ...|..::|||..: |||:.|:..:
Human   569 PASPAERRP-------------PVSPPNRRR---KGERGEKQRKPGGS-SWKTFFALGRGPSVPR 616

  Fly   769 ---------RQGNPDP-GQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNE 823
                     .:..|.| |.:..|....|..|..|....:.....:.|.:..:|.|    .:.:..
Human   617 KKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHS----SSDAFP 677

  Fly   824 RDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRG---------HMTTC--------- 870
            ..|.|...|      :||.:...|.|.|.:|.....:|...|         |.|:.
Human   678 VGPAPAGSC------ESLSSSSSSESSSSESSSSSSESSAAGLGALSGSPSHRTSAWLDDGDELD 736

  Fly   871 --PSRELSEL-GLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQT 932
              |.|.|..| ||:||     ...|..|......|.......|||..||..  .|..|:..|.:
Human   737 FSPPRCLEGLRGLDFD-----PLTFRCSSPTPGDPAPPASPAPPAPASAFP--PRVTPQAISPR- 793

  Fly   933 NSVNPSPKKQPRLNLLSPSSARTMPPPPL------SAPGTASSSCGHESG-------------GA 978
               .|:....|....:|...|.::||..|      .||.:|:.:.....|             ||
Human   794 ---GPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGA 855

  Fly   979 E----NCCKRYKLEDQLC------------DIQFIDCGTPENVPTTQQQFASVEVHPPPK-PAR- 1025
            |    :.|     :.::|            |::     :|...|............|||| |||
Human   856 EAPLTDAC-----QQEMCSKLRGAQGPLGPDME-----SPLPPPPLSLLRPGGAPPPPPKNPARL 910

  Fly  1026 --------------------------ANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQD 1064
                                      |:|||...|....||.....|..|.|
Human   911 MALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGP------------- 962

  Fly  1065 AKERFSYQGTFTQ------PGQKQESS---APRPVHSTNNGATLRKP-------------RVEPV 1107
            .....::.|.:..      |.|:.:.|   :.||:.::..|  ||.|             |..|.
Human   963 PPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRG--LRGPAQVSAQLRAGGGGRDAPE 1025

  Fly  1108 EDGQ----IKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSS 1168
            ...|    :...||||...:.:||..|          ...:..|:..:.||...|...     ||
Human  1026 AAAQSPCSVPSQVPTPGFFSPAPRECL----------PPFLGVPKPGLYPLGPPSFQP-----SS 1075

  Fly  1169 NVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRA 1233
            .....:..||..|......:.:..:|.:..:.:....|..:..:
Human  1076 PAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFR--------------------- 1119

  Fly  1234 ATLPVKDQLQAAAAAMCSSP---NNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVY 1295
             ::| .|:|.|:...:..||   .:.:|.  .|....||.:...||......|.........|:|
Human  1120 -SMP-PDRLNASYGMLGQSPPLHRSPDFL--LSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLY 1180

  Fly  1296 EDFEQTPVKMVPSPIKSTISITYKSPEKEKKP 1327
            .:....|  ..|||..|:.|.....|.....|
Human  1181 VNLALGP--RGPSPASSSSSSPPAHPRSRSDP 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	31/112 (28%)
		SH3_ARHGAP32_33	299..358	CDD:212769	30/58 (52%)
		RhoGAP_CdGAP	420..613	CDD:239849	122/195 (63%)
		FliJ	1322..1457	CDD:304890	1/6 (17%)
ARHGAP33	XP_006723062.1	PX_domain	56..168	CDD:295365	37/138 (27%)
		SH3_ARHGAP32_33	190..243	CDD:212769	30/58 (52%)
		RhoGAP_CdGAP	312..506	CDD:239849	122/195 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146170
Domainoid	1	1.000	194	1.000	Domainoid score	I3172
eggNOG	1	0.900	-	-		E1_KOG1449
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		otm41939
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730