DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Bcr

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	NP_001074881.1	Gene:	Bcr / 110279	MGIID:	88141	Length:	1270	Species:	Mus musculus

Alignment Length:	204	Identity:	73/204 - (35%)
Similarity:	104/204 - (50%)	Gaps:	31/204 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 RSFILSR-PSRRRLKQSGIY---------RERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV 453
            |.|.|.| |||   ||:|::         |||              ..:|.::|.|.|.||..|:
Mouse  1035 REFSLKRMPSR---KQTGVFGVKIAVVTKRER--------------SKVPYIVRQCVEEIERRGM 1082

  Fly   454 ID-GIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDN 517
            .: ||||:||:.::||.|:.|||... .|:.....:.|::|::..||:||||||.||.|.:.|.|
Mouse  1083 EEVGIYRVSGVATDIQALKAAFDVNN-KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPN 1146

  Fly   518 FVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPN 582
            |.|.|.:....|.|  ..|...:|.||..:..|..:|.:||.:|::......|:..|||.|:.|.
Mouse  1147 FAEGIALSDPVAKE--SCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPT 1209

  Fly   583 LLRSPALES 591
            |||....||
Mouse  1210 LLRPSEKES 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365
		SH3_ARHGAP32_33	299..358	CDD:212769
		RhoGAP_CdGAP	420..613	CDD:239849	61/173 (35%)
		FliJ	1322..1457	CDD:304890
Bcr	NP_001074881.1	Kinase. /evidence=ECO:0000250\|UniProtKB:P11274	1..428
		Bcr-Abl_Oligo	3..75	CDD:286168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..173
		Binding to ABL SH2-domain. /evidence=ECO:0000250	198..387
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..481
		RhoGEF	501..689	CDD:279015
		PH-like	683..876	CDD:302622
		C2_ABR	912..1032	CDD:176068
		RhoGAP_Bcr	1051..1251	CDD:239852	63/185 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940