DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and Arhgap33

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_038949821.1	Gene:	Arhgap33 / 100362311	RGDID:	2318374	Length:	1354	Species:	Rattus norvegicus

Alignment Length:	1434	Identity:	425/1434 - (29%)
Similarity:	596/1434 - (41%)	Gaps:	364/1434 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ALASAEAGGIGGVNGGPIACHA-----STDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPG 76
            |..|..|...||..|.|.|.||     ...:..:...|:.....|:.:..|.........|||.|
  Rat    16 ARQSPPAAVRGGACGRPRAPHALPFVSPWRRRRRQRGLRTRARKPSGSEEATATMVARSTDSLDG 80

  Fly    77 LSYQDMFASMNTSQISNASTESSCSPPIQGAVPPP-------KPSRHMAVQPLNSKSCRFPKLEE 134
                              ..|||..|     |||.       ||.:.     |::....||:|.:
  Rat    81 ------------------PGESSVQP-----VPPTGGPGTKGKPGKR-----LSAPRGPFPRLAD 117

  Fly   135 CAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEP 199
            |||||||.|..|.:.:.|   ..|..|.|::.::               |..:.:...|..|..|
  Rat   118 CAHFHYENVDFGHIQLLL---SPEREGPSLSGEN---------------ELVFGVQVTCQGRSWP 164

  Fly   200 FLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYA-------VAKYLERFSK 257
            .|  ||:::.:.||..||||::||:.|.|       .|||...:...|       :.:|||..|.
  Rat   165 VL--RSYDDFRSLDAHLHRCIFDRRFSCL-------PELPPPPEGARAAQMLVPLLLQYLETLSG 220

  Fly   258 IASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMI 322
            :...:|.||.:|||::|||.||||.|::   :.::|.|||.||:.|:||.||||||::.||||::
  Rat   221 LVDSNLNCGPVLTWMELDNHGRRLLLSE---EASLNIPAVAAAHVVKRYTAQAPDELSFEVGDIV 282

  Fly   323 SVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATI------GDKVPRNFPM---PAPLVGH 378
            ||||||...:..|||||:.      ::|||||..||...      |.|.....|:   |||   .
  Rat   283 SVIDMPPTEDRSWWRGKRG------FQVGFFPSECVELFTERPGPGLKADAEGPLCGIPAP---Q 338

  Fly   379 LDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRS 443
            ..:|.|..|.|..|||....|:|:.|||||:||:|.||.|:|||.|||.|||.|||||:|.|||.
  Rat   339 GISSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRC 403

  Fly   444 CAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNP 508
            |:||||.:||:||||||||::|||||||..||.||:|:|..|...||||:||||.|:||||||||
  Rat   404 CSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNP 468

  Fly   509 LCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDK 573
            |.|||||..|.||:.|..:|  |||..:.:.:.:|||||||||:||..||.::::|...|.|..:
  Rat   469 LLTYQLYGKFSEAMSVPGEE--ERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHAR 531

  Fly   574 NLAIVWAPNLLRSPALES---GGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASAT 635
            |||||||||||||..|||   ||.||.|.|.||:||.|:|:.:...:|.            .:.|
  Rat   532 NLAIVWAPNLLRSMELESVGLGGAAAFREVRVQSVVVEFLLTHVEVLFS------------DTFT 584

  Fly   636 AAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSL--STGGAKLISLEEAQERHSRVE 698
            :|..:.||         .|               ::.|||||  |:...:|::|||||   :|.:
  Rat   585 SAGLDPAG---------RC---------------LLPRPKSLAGSSPSTRLLTLEEAQ---ARTQ 622

  Fly   699 GADLKQSLPISMLTSAS--------------SNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSW 749
            |.....:.|.:..|.||              ....|:..::..:|.|| |:|.|      .|..|
  Rat   623 GRLGTPTEPTTPKTPASPVERRKRERVEKQRKPGGSSWKTFFALGRGP-SIPRK------KPLPW 680

  Fly   750 QKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSI 814
                          .|.|:....|...:..|..::.:.:......|||.| ..:.|.:..:|.|
  Rat   681 --------------LSGSRAPPQPSGSRPDTVTLRSAKSEESLSSQASGA-GLQRLHRLRRPHS- 729

  Fly   815 ELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRG---HMTTC------ 870
               .:.:....|.|...|...:|..|..:...|.|.|..|...|  .|..|   |.|:.
  Rat   730 ---SSDAFPVGPAPAGSCESLSSSSSSSSSSSSSSSSESSAAGL--GPLSGSPSHRTSAWLDDGD 789

  Fly   871 -----PSRELSEL-GLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFS 929
                 |.|.|..| ||:||     ...|..|......|.......||||.||..  .||.|:..|
  Rat   790 ELDFSPPRCLEGLRGLDFD-----PLTFRCSSPTPGDPAPPASPAPPASASAFP--PRATPQALS 847

  Fly   930 SQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDI 994
            ..    .|.|.....|::..| .|.::||..|...|         :|||
  Rat   848 PH----GPKPASPTALDISEP-LAVSVPPAVLELLG---------AGGA---------------- 882

  Fly   995 QFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKR 1059
                                        ||.|..:|..|.|       .....:..|.:..||:.
  Rat   883 ----------------------------PASATPTPALSPN-------PGLRPHLIPLLLHGAEA 912

  Fly  1060 KEQQDAKERFSYQGTFTQ--PGQKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTP 1122
            :.....::..|.:...|:  |||........|:  .....:|.:|...|         .|.|..|
  Rat   913 QLSDTCQQEISSKLAPTRGAPGQHSPGGMDSPL--LPPALSLLRPGGAP---------PPPPKNP 966

  Fly  1123 ARSPRYSLLLCD-----TESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDAS 1182
            ||  ..:|.|.:     .|.........||...:.|...:                   |.::..
  Rat   967 AR--LMALALAERAQQVAEQQSQQGQGGTPPAPLSPFRRS-------------------LSLEVG 1010

  Fly  1183 SSYLGSSHESLGQNINNHHDA-----------EQRDMNALKRELSLDLNPLQPRLPQ--PANRAA 1234
            ...:|:|...|......|..|           :|.|.:.::.:..|..:...||.|.  .|:..|
  Rat  1011 GEPVGTSGSGLHPPSLAHPGAWAPGPTPYLPRQQSDGSLVRSQRPLGTSRRGPRGPSQVSAHLRA 1075

  Fly  1235 TLPVKDQLQAAAAAMCSSP---NNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSL----LATDESS 1292
            :...:|..:.||.:.||.|   :|.:|. :|.:...||..|   :.:| .::||    ...:..:
  Rat  1076 SGAYRDTPEMAAQSPCSIPSQGSNPSFL-STPRECLPSFLG---VPKQ-GLYSLGPPSFPPNSPA 1135

  Fly  1293 PVYEDFEQTPV------------------------------KMVPSPIKSTISITYKSPEKEKKP 1327
            ||:.:....|.                              .|.|..:.::..:..:||...:.|
  Rat  1136 PVWRNSLGAPPALDRGENLYYEIGVGEGTYSGPSRSWSPFHSMPPDRLNASYGMLGQSPPLHRSP 1200

  Fly  1328 SAIL 1331
            ..:|
  Rat  1201 DFLL 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	31/112 (28%)
		SH3_ARHGAP32_33	299..358	CDD:212769	31/58 (53%)
		RhoGAP_CdGAP	420..613	CDD:239849	122/195 (63%)
		FliJ	1322..1457	CDD:304890	2/10 (20%)
Arhgap33	XP_038949821.1	PX_TCGAP	125..237	CDD:132832	37/138 (27%)
		SH3_ARHGAP32_33	259..312	CDD:212769	31/58 (53%)
		RhoGAP_CdGAP	380..574	CDD:239849	122/195 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339929
Domainoid	1	1.000	194	1.000	Domainoid score	I3072
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105523
Panther	1	1.100	-	-	O	PTHR15729
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.840