DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CdGAPr and arhgap9

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_005172184.2	Gene:	arhgap9 / 100334461	ZFINID:	ZDB-GENE-110510-2	Length:	855	Species:	Danio rerio

Alignment Length:	754	Identity:	176/754 - (23%)
Similarity:	290/754 - (38%)	Gaps:	183/754 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDKVSTSLAAQLHSHAL-----ASAEAGGIGGV--NGGPIACHASTDKDAQAPPLQFEMDAPAA 58
            :.:|.::..||:.|...|     |||:....||:  .|.|||...|:....|.|   ::..:.:.
Zfish   155 LMEKQASGAAARAHFPMLPFSGSASAQLTLPGGLLSPGAPIARSQSSSNLPQNP---YQESSRST 216

  Fly    59 AISAQLNFK------IVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHM 117
            |.|...::.      ..|.....|.......|.::.|.:|.|.......||  ..:|..||
Zfish   217 ACSPSRSYSQWDMNTAAPRRHTHGHMQLSSSAYISQSSLSEAGRRQWSEPP--SPLPGQKP---- 275

  Fly   118 AVQPLN--SKSCRFPKLEECAHFH---YERVQLGPLSVQLLDDKSE----HMGS--------SIA 165
             :|.|.  .:.|. |....|.:.:   .||....|...:..:...:    |.|:        |:.
Zfish   276 -LQTLQQWEQYCD-PATGRCYYINTDTKERSWKPPRRARQTNHSQQVNAVHAGTVQRDIRLLSLP 338

  Fly   166 SQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYD-------- 222
            .||.|.    ||:...||:..:              |.......||...|......|
Zfish   339 LQSTGS----SSMHRLSPDLSY--------------ISHDANGWQLSQSMQRAASSDALSSASSM 385

  Fly   223 -----RKISGLR-NMEELAAE----LPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNK 277
                 |:.|.|. .|..::..    |||:.......:.|.......:|||          ..|::
Zfish   386 FDDTPRRNSALSGGMAHISHSYSMILPSQRTATNGQSDYRVVVEPPSSDS----------SPDSE 440

  Fly   278 GRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPS------------- 329
            |....|   |....:|...:  |.|.|:.:........:.||:.:.....|.
Zfish   441 GVTPEL---EKAGLLNKTKI--AEGGRKLRKNWNPSWVVLVGNSLVFFKDPKSQNPESWKPGNSR 500

  Fly   330 PAESIWWRGKKSHLQ--------KSLYEV------GFFPQS-----------CVATIGDKVPRNF 369
            |..|:..||  :.||        |:::::      .|..||           .:..:.|::.:..
Zfish   501 PESSVDLRG--AQLQWANDLSSKKNVFKLRTITGNEFLLQSETDSLIREWYRTIQNVIDRLDKEN 563

  Fly   370 PMP---------APLVGHLDASPTKPVLR-----------------KHGKLIAFFRSFILSRPSR 408
            |:.         |..|..||.|..:..:|                 :|.::.:..:..||.||..
Zfish   564 PLDNVLLYSLRRAGSVELLDHSGDEDEVRGGIKASLPRSTSNLENSEHKRVKSRLKKLILRRPPL 628

  Fly   409 RRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRR 472
            :.|::.|:.:::||.|.|..........:|..:|.|.|.:|..|: .|||||:||..:.||:||.
Zfish   629 QTLQEKGLIKDQVFGCSLELLCEREKCTVPQFVRKCTEAVERKGLETDGIYRVSGNLAVIQKLRF 693

  Fly   473 AFDEERVP-----------------DLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVE 520
            |.:.||..                 ||.:|:. :|||.::..||::|||||.||..:..:.:||:
Zfish   694 AVNHERAVTTDGRYLFPEALVQERLDLDDPQW-EDIHVITGALKLFFRELPEPLVPFSAFHDFVD 757

  Fly   521 AIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLR 585
            :|:: ||.. ||:..:|..||.|||.:..||:::..||.:|.:......|:.:|:.||:.|.|:|
Zfish   758 SIKI-ADHL-ERVERLKMLVLSLPPANQHTLQHMIRHLRRVMERSDSNRMSTQNIGIVFGPTLMR 820

  Fly   586 SPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDALDDH 624
             |..|||.:|.......||:  |.|:....:|| .:::|
Zfish   821 -PENESGNMAFNMVYQNQAI--ETLLSQYQHIF-RINEH 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	22/123 (18%)
		SH3_ARHGAP32_33	299..358	CDD:212769	16/96 (17%)
		RhoGAP_CdGAP	420..613	CDD:239849	73/210 (35%)
		FliJ	1322..1457	CDD:304890
arhgap9	XP_005172184.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940