DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CdGAPr and arhgap33

DIOPT Version :9

Sequence 1:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster
Sequence 2:	XP_031760545.1	Gene:	arhgap33 / 100037855	XenbaseID:	XB-GENE-852586	Length:	1280	Species:	Xenopus tropicalis

Alignment Length:	1430	Identity:	423/1430 - (29%)
Similarity:	601/1430 - (42%)	Gaps:	383/1430 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 PADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEE 134
            |.|:.......|...|.|.|::    ..|:.:|.::|     :||:.:...|       |.||.:
Frog    16 PPDTEQKARGTDTLDSANESRL----LSSAANPGVKG-----RPSKRITRGP-------FVKLAD 64

  Fly   135 CAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRV-CPQRCE 198
            |||:|||.|..||:.:.|.|.::|..||:      .||:             .:|::| |..|
Frog    65 CAHYHYENVNYGPIQLGLSDSRTEDAGST------EGDV-------------IYIVQVTCQGR-- 108

  Fly   199 PFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESD-VEYAVAKYLERFSKIASDS 262
            .:.:.||:|:.::||..||||::||:.|.|..:.. .:|||::.. :...:::||:..:.|...:
Frog   109 SWSVLRSYEDFRVLDSNLHRCIFDRRFSQLLELPP-RSELPAQGQLLAPLLSRYLKGLTGIVDSN 172

  Fly   263 LTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDM 327
            :.||.||.|:::||.|.||.:.:   :.:||.||:.||:.::||.||||||::.||||::|||||
Frog   173 INCGPILNWMEIDNHGNRLLVNE---EASINVPAIAAAHVIKRYTAQAPDELSFEVGDIVSVIDM 234

  Fly   328 PSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGD-KVPR-------NFPMPAPLVGHLDASPT 384
            |...::.|||||.|      ::|||||..||..|.| |.|.       ..|:..|   |...||
Frog   235 PPREDTSWWRGKHS------FQVGFFPSECVQLITDSKSPSPTGEGDVKLPITPP---HGSNSP- 289

  Fly   385 KPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIE 449
            :||.|:||||....|||:.||||::||:|.||.|||||..||.|||||||:::|.||..||:|||
Frog   290 RPVCRRHGKLAGLLRSFMASRPSKQRLRQRGILRERVFGTDLGEHLLNSGEEVPRVLLCCAQFIE 354

  Fly   450 NYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQL 514
            .:||:||||||||::||||:||..||.||:|||......||:|.||||.|:|||||||||.||:|
Frog   355 KFGVVDGIYRLSGVSSNIQKLRHEFDSERIPDLSRDTFLQDVHCVSSLCKLYFRELPNPLLTYRL 419

  Fly   515 YDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVW 579
            |..|.||:.. |.|.|:.:| :.:.:.:|||||||||:||.:||.::|.|..||||..:||||:|
Frog   420 YQPFTEAMSA-ATEEDKLIR-VHDLIQQLPPPHYRTLEYLMKHLSQLSTHSDRTGMHARNLAIIW 482

  Fly   580 APNLLRSPALES---GGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANA 641
            |||||||..:||   .|..|.|.|.||:|:.|:|:.|...:|........|...:...:......
Frog   483 APNLLRSRDMESVGTPGADAFREVRVQSVLVEFLLCNVETLFSDTFTSIGRCGPIRPRSLLGVCP 547

  Fly   642 AGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSL 706
            :|   ||.||.:.::....|||..:.||..:...:.:..|     ||.::||.:   ....|:|
Frog   548 SG---RLVSLQEAQARSQSQREAAEKLGAEKASPTKAERG-----LESSEERKA---ARGRKKS- 600

  Fly   707 PISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQG 771
                                  |||.|     :.|..:..::...:|           ||....|
Frog   601 ----------------------GGGSS-----WRTFFAIGKNSSHKK-----------SRPGGIG 627

  Fly   772 NPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSN 836
            |.....:    |.|:|..|       .|.:.:.|..|.....   |:.:|..|.|       ||.
Frog   628 NAAAHPR----VSDTVTLR-------SAKSEESLCSHTSGTG---LQRSSRLRRP-------RST 671

  Fly   837 SIDSLRT-VGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELS-----EL----------GLNFDRE 885
            | |.|.| :.|||||  :|......||.........:|..|     ||          ||.||
Frog   672 S-DGLTTRLPHSRSV--ESLGPSSPSPPCVPSPPASARPQSAWIEEELDLSPPLPDTDGLGFD-- 731

  Fly   886 EP-EMRI-FSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFS-SQTNSVNPSPKKQP--RL 945
             | ..|: ||:.|...|...|..|...||       :.:|.|...| |.|...:|||...|  ||
Frog   732 -PLSFRLSFSDHEEAKSPIIVRAEITSPA-------LAKALPRGVSLSPTAGCSPSPTHSPPERL 788

  Fly   946 NLLSPSSA-RTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTP--ENVPT 1007
            .:..||.. |.:.|||........|            |:::..:..:.:::....|.|  |..|.
Frog   789 LVDGPSQGPRDLSPPPQMLSLLLQS------------CQQHLSDKSVREVKGKLTGAPGQEEPPN 841

  Fly  1008 TQQQFASV---------EVHPPPKP---------------ARANQSPIS--------SSNGASVG 1040
            :.....|.         ::.|||.|               .||.|:.||        |...|.:.
Frog   842 SLSPQESAQPPSLSLLRQLPPPPPPKDPARLMALRLAESAQRALQASISIGTVPAKVSQRSAPMN 906

  Fly  1041 SSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQK-------QESSAPRPVHST----N 1094
            ..:|:.|.|     |..:..|....:|.:|   ....|...       |......|.|:|    :
Frog   907 PPTSAFRRS-----LSMECSESAVPRELYS---DLRPPALSTNDKSVGQHRPLRLPAHNTLAPSS 963

  Fly  1095 NGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRY-----SL----LLCDTESSDNSSAVNTPQY- 1149
            :.|.:|||             .||...|.|:||.     ||    .||...       :..|.|
Frog   964 SPADVRKP-------------TPTGIPPTRAPRLHTRSGSLPAPPSLCPPR-------IRPPPYR 1008

  Fly  1150 --------------------------------DMEPLML--------------TSAMSGVS---- 1164
                                            .|.||..              :.|.||..
Frog  1009 FPEEGPRLPHQCSAPPWPEPEGLYYEIVGDPPHMAPLNTSYGLIQPPWPHVGSSQAHSGFGNWYG 1073

  Fly  1165 ---GVSSNV------------QQQQLLLGVDASSSY------LGSSHESLGQNI----NNHHDAE 1204
               |....|            |.:..::|......|      :|...|.:..|:    ...||.
Frog  1074 ASHGTDPEVVAYSRWDRGLHPQLRPYMVGGGVHYPYVRTPESVGKREEPIYVNLPLKGREQHDG- 1137

  Fly  1205 QRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPS 1269
            ..|:..||.||     |.:.|.|.|.:.|    ..:.::..|......|:......:......||
Frog  1138 TNDVAGLKPEL-----PQKQRPPNPPSMA----YHESIRGVAQRQVRHPHLLRREGSLGYFRPPS 1193

  Fly  1270 E----YGYQHL-------------------QRQLSMHSLLATDESSPVYEDFEQ--------TPV 1303
            .    :|.||.                   ||...:|......|...:|.:.||        |||
Frog  1194 SHKAMWGTQHKFPQGRENPIFAYEAPTGAGQRMRYVHPHCLLSEEGTLYGNLEQRGVQHRSATPV 1258

Fly 1304 1303
Frog 1259 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	30/107 (28%)
		SH3_ARHGAP32_33	299..358	CDD:212769	31/58 (53%)
		RhoGAP_CdGAP	420..613	CDD:239849	113/195 (58%)
		FliJ	1322..1457	CDD:304890
arhgap33	XP_031760545.1	PX_TCGAP	72..184	CDD:132832	38/133 (29%)
		SH3_ARHGAP32_33	206..259	CDD:212769	31/58 (53%)
		RhoGAP_CdGAP	325..517	CDD:239849	112/193 (58%)
		PHA03247	<719..1056	CDD:223021	80/386 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I3277
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003732
OrthoInspector	1	1.000	-	-		otm49161
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2589
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000