Protein Alignment CdGAPr and arhgap21

DIOPT Version :9

• Sequence 1: NP_001260600.1
• Gene: CdGAPr / 35267
• FlyBaseID: FBgn0032821
• Length: 1843
• Species: Drosophila melanogaster
• Sequence 2: XP_031759009.1
• Gene: arhgap21 / 100037846
• XenbaseID: XB-GENE-1011028
• Length: 1952
• Species: Xenopus tropicalis
• Alignment Length: 1337
• Identity: 273/1337 - (20%)
• Similarity: 477/1337 - (35%)
• Gaps: 428/1337 - (32%)

  Fly     2 SDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPP-----LQFEMDAPAAAIS 61
            |.|:..:.|::.:|.::.|.:  ||..........|.|..::.|..|     |.|::|:...:.|
 Frog   630 SVKIPATYASKPYSPSVGSED--GIVKDQKAVNYIHVSGPQNFQRKPQTESALGFQLDSLKTSTS 692

  Fly    62 AQLNFKIVPADSLPG-------LSYQDMFASMNTSQISNASTESSC-------------SPPIQG 106
            |..:   .||.:.|.       .:.|::......|..:|||..:|.             ||..|.
 Frog   693 ASSS---SPAHTKPAKQVKHSTATSQNVDGKKTQSPEANASDSNSVLTSIDQVVLREKPSPGQQT 754

  Fly   107 AVPPPKPSRHMAVQPLNSKS---CRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIA--- 165
            :.|..:||...||..:...|   |..|. :.....|.:|::      |.....|:..|.|:|
 Frog   755 SQPIRQPSYIFAVSDVEGASDTTCWLPN-DARREVHIKRIE------QKKASGSDSPGDSLASIP 812

  Fly   166 ------SQSLG---GDLPHSSLRSFSPESCWFIIRVCPQRCEPF-LIKRSF-------------- 206
                  |.|:.   .::|.|::.|.|.:....|..|.|....|. ||:|.|
 Frog   813 FIDEPTSPSIDHEIANIPASAVISISVQPLPTITTVPPSPTSPVPLIRRHFSHDHDSIRPSILEV 877

  Fly   207 ----ENMQLLDEMLHRCVYDRKIS--------GLRNMEELAAELPSESDVEYAVAKYLERFSKIA 259
                |..:..||.|.....:.|:|        |::..|.:.:...|||..:.:        |.:.
 Frog   878 NSKTERSKSCDEGLDDYKDEGKLSLKQGSSLKGIKARENVPSSEDSESRKDSS--------SDVF 934

  Fly   260 SDS----------LT-------CGTILTW-------------LQLDNK---GRRLPLADGETQRT 291
            |||          ||       .|::..|             ||.|.|   |.....:|.|....
 Frog   935 SDSNKEGFLYFRQLTTEKGKRVSGSMRPWKQMYVVLRGSALYLQKDKKEQSGHSSAQSDEEQLIG 999

  Fly   292 INTPAVGAAYGVRR---------------YQAQAPDE-------------INIEVGDMIS--VID 326
            ||...:..:|...:               :||:..|:             :|.|..|..|  :|.
 Frog  1000 INGCLIDISYSETKRKNVFRLTTSDREFLFQAEDRDDMLAWIKAIQENGNLNDEQTDQASRVLIS 1064

  Fly   327 MPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKH 391
            ......:.......:..::|       |:....|:..:.|.....|.   |.|. ||..|.....
 Frog  1065 KRIKEYNTMMSSSSNKSEQS-------PKPSRQTLSIRQPFRATKPE---GKLQ-SPHSPKQESE 1118

  Fly   392 GKLIA-----------FFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCA 445
            .:|.:           .:|. |:.:|..::....|.:..|:.:|..:    ::.:.:|:::..|.
 Frog  1119 RRLFSKDDISPPKDKGSWRR-IMKKPFEKKPTTGGTFGVRLDDCPPA----HNNKYVPLIVDVCC 1178

  Fly   446 EFIENYGV-IDGIYRLSG----ITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFREL 505
            :.:|:.|: ..||||:.|    |:|..:.|.:...:..:.|    :..:|::.:|||||.:||:|
 Frog  1179 KLVEDRGLETTGIYRVPGNNAAISSMQEELNKGSTDIDIQD----DKWRDLNVISSLLKSFFRKL 1239

  Fly   506 PNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGM 570
            |:||.|.:.|::|:||  .:.::..|||:.:|..:|.||..||.|||||:.||..|:::..:..|
 Frog  1240 PDPLFTNEKYNDFIEA--NRTEDPVERLKTLKRLILDLPDHHYETLKYLSAHLKAVAENSEKNKM 1302

  Fly   571 TDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIF----------------- 618
            ..:|||||:.|.|:|:.  |......:..:..|..:.|.||:. |:.|
 Frog  1303 EPRNLAIVFGPTLVRTS--EDNMTHMVTHMPDQYKIVETLIQQ-HDWFFSEESADEPITAVQEES 1364

  Fly   619 -------------------------DALD----------------DHPARHSMVASATAAAANAA 642
                                     |..|                |..:|..:|:|..|||:...
 Frog  1365 TVESQPVPNIDHLLPNIGRTGLSPGDVSDSASDSAKSKGSWGSGKDQYSRELLVSSLFAAASRKR 1429

  Fly   643 GGE----------------------LRLE--------------------SLTDCESL-------- 657
            ..:                      |::|                    ||.|.:::
 Frog  1430 KKQRDKPQPSSSEDELDNVFYQKELLQVEFQRPDKQNVDKDVDLKANALSLKDADNIKGTNIIKE 1494

  Fly   658 ------------------------LVEQR--EQDQSLGVV--ERPKSLSTGGAKLISLEEAQERH 694
                                    :|..|  ..|:::..:  :..:|:|..|..|.:..:|..:.
 Frog  1495 DKLEKDIMHSEATSPCPPKLSEPPIVNHRLPPDDKNIPQISFQMEESMSDSGTMLSTSSQASAQR 1559

  Fly   695 S--RVEGADLKQS----LPISMLTSASSNAASNIGSYI----------EVGGGPSS----LPDKY 739
            |  :|...:||.|    ..:|.:||..|..:|.|  ||          ||.....|    ..|:.
 Frog  1560 SKPKVVSPELKGSDFLTADVSSITSDYSTTSSTI--YITGLDQNLISPEVQSVAESKGEEADDER 1622

  Fly   740 HTVLSAPRSWQKRKPDKTPSWKS--IFSRSQRQGNPDPGQKITTDVK------------------ 784
            ..::|..|..:....:..|.:.|  .|.|..|....:|.:.:..:.:
 Frog  1623 SELISEGRPMETDSENDFPIFASSIAFDRQHRSKVEEPTRNVQVNSEGSPSCTEGSITPRMDRRR 1687

  Fly   785 ---------DSVASRVSFVQASHAHASKELTKHD----------KPKSIELLETTSNERDPKP-- 828
                     |:::.:.|..|.:.:..|.|....:          |.:|:.:.:||:|....:|
 Frog  1688 FSSHKLIECDTLSRKKSIRQKTDSECSAESKNEETLSDAQEAVKKGRSLSIGDTTTNNEPEEPAW 1752

  Fly   829 -------MDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELG-LN-FDR 884
                   :.|.::: |.|.:..:|..::.:.::  ...::.:|.| |....|:.:|:. || :..
 Frog  1753 RIKITERLKLRLKA-SADDMFGIGSQKAQAAET--RKKKNIRRRH-TLGGQRDFAEISVLNAWKI 1813

  Fly   885 EEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPK--------K 941
            .||     |..|:.:|:....|...|....|.:..:.|.|....:|:.:.|.|..|        |
 Frog  1814 NEP-----SSKEAELSAVDRLKPKCPSQDLSISDWLARERLRTSTSELSMVEPEEKRISDATSQK 1873

  Fly   942 QPRLNLLSPSSARTMPPPPLSAP---GTASSSCGHES 975
            :|    .|||     ||||.|:|   .||..:.|.||
 Frog  1874 EP----ASPS-----PPPPASSPSQVSTAIVTAGSES 1901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	33/165 (20%)
		SH3_ARHGAP32_33	299..358	CDD:212769	11/88 (13%)
		RhoGAP_CdGAP	420..613	CDD:239849	63/197 (32%)
		FliJ	1322..1457	CDD:304890
arhgap21	XP_031759009.1	PDZ_signaling	55..165	CDD:238492
		PH_ARHGAP21-like	938..1051	CDD:269955	17/112 (15%)
		RhoGAP_ARHGAP21	1153..1348	CDD:239860	64/207 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940