Protein Alignment bsh and NKX6-2

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 251
• Identity: 73/251 - (29%)
• Similarity: 98/251 - (39%)
• Gaps: 74/251 - (29%)

  Fly   191 PLNGGSGASNGVLYPNAPY-TDHGFLQM-----------TLGYLSPSSGTYKSVDPYF------- 236
            |..||.||       ..|. |.||...:           .||.|...:|...|...||
Human    43 PALGGLGA-------QLPLGTPHGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVA 100

  Fly   237 ----LSQASLFGGAPFF------GAPGCVPELALGLGMGVNALRHCRRRKARTVFSDPQLSGLEK 291
                ...|.|.|..|.|      |||...|.||.....|....:..:::.:|..||..|:..|||
Human   101 RGYPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEK 165

  Fly   292 RFEGQRYLSTPERVELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANEPVDFSRSEPGKQPGE 356
            .||..:||:.|||..||.:||::|:|||.||||||.|.:|:     :|.|.....:.:
Human   166 TFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKR-----HAVEMASAKKKQ------- 218

  Fly   357 ATSSSGDSKHGKLNPGSVGGTPTQPTSEQQLQMCLMQQGYSTDDYS-DLEADSGDE 411
                  ||...||   .|||:..:                ..|:|: .|:.:|.||
Human   219 ------DSDAEKL---KVGGSDAE----------------DDDEYNRPLDPNSDDE 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	29/55 (53%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		14/52 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		4/22 (18%)
		Homeodomain	147..205	CDD:459649	29/57 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		14/72 (19%)