Protein Alignment bsh and NKX2-4

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 101/374 - (27%)
• Similarity: 140/374 - (37%)
• Gaps: 96/374 - (25%)

  Fly    42 TPFSIEHILFQNLNSASNNNNSSDTNGIAANTNNYAPKSSRNAVKSARSAFAHDNNPHKHPS--- 103
            ||||:..||.....:....:.:.|    .|.....||..:..|.::          |...||
Human     9 TPFSVSDILSPIEETYKKFSGAMD----GAPPGLGAPLGAAAAYRA----------PPPGPSSQA 59

  Fly   104 ------QHSHPPQSHPPASASASATATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHGT--SHY 160
                  |.||....|..|:|:|:|.|.|   .||:.|         |..|..:... ||.  |:.
Human    60 ATVAGMQPSHAMAGHNAAAAAAAAAAAA---AAAATY---------HMPPGVSQFP-HGAMGSYC 111

  Fly   161 NGDQISQQLGSGAAQHPPVPTTQPQPPPPPPLNGGSGASNGVLYPNAPYTDHGFLQMTLGYLSPS 225
            ||       |.|.....|..|        ..:.||:........|:..|:.      ...::.||
Human   112 NG-------GLGNMGELPAYT--------DGMRGGAATGWYGANPDPRYSS------ISRFMGPS 155

  Fly   226 SGTYKSVDPYFLSQASLFGGAPFFGAPGCVPELALGLG-MGVNALRHCRRRKARTVFSDPQLSGL 289
            :|...:      ...||.|          :.:.|..|| :...|.....|||.|.:||..|:..|
Human   156 AGVNVA------GMGSLTG----------IADAAKSLGPLHAAAAAAAPRRKRRVLFSQAQVYEL 204

  Fly   290 EKRFEGQRYLSTPERVELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANEPVDFSRSEPGKQP 354
            |:||:.|:|||.|||..||:.:.|:.||||.||||.|.|.|:|  .:|.|.:.:   :.|.|..|
Human   205 ERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQ--AKDKAAQQL---QQEGGLGP 264

  Fly   355 GEATSSSGDS-------KHGK--------LNPGSVGGTPTQPTSEQQLQ 388
            ......|...       |.||        ..||..|..|..||...:|:
Human   265 PPPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAGPQPPAPTPAPELE 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	30/55 (55%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		17/73 (23%)