Protein Alignment bsh and NKX1-2

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 81/319 - (25%)
• Similarity: 106/319 - (33%)
• Gaps: 118/319 - (36%)

  Fly    77 APKSSRNA---VKSARSAFAHDNNPHKHPSQHSHPPQSHPPASASASATATARSNQAASGYAGED 138
            ||:.:|.:   |::.:.|.:.|      |.:....|.:..|.:..||   ....::|......||
Human    42 APREARKSLAEVEAGKDASSRD------PVRQLETPDAAGPGAGQAS---PLEGSEAEEEEDAED 97

  Fly   139 YGKSMHSTPRSNHHSRHGTSHYNGDQISQQLGSGAAQHPPVPTTQPQPPPPPPLNGGSGASNGVL 203
            ..:     ||....             :.:|..|.|:.|..|.                   |.|
Human    98 PRR-----PRLRER-------------AARLLPGLARSPDAPA-------------------GAL 125

  Fly   204 YPNAPYTDHGFLQMTLGYLSPSSGTYKSVDPYFLSQASLFGGAPFFGAPGCVPELALGLGMGVNA 268
            ....|..|.                               ||.|....||           ...:
Human   126 ASGEPCEDG-------------------------------GGGPVRSPPG-----------SPGS 148

  Fly   269 LRHCRR---------RKARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWFQN 324
            .|..||         |:|||.|:..||..||.:|...||||..||:.||.:|.|:|||||.||||
Human   149 PRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQN 213

  Fly   325 RRMKHKKQLRRRDNANEPVDFSRSEPG--KQPGEATSSSGDSKHGKLNPGSVGGTPTQP 381
            ||.|.|||       |...|.:....|  .|||.|....|         |..||:|..|
Human   214 RRTKWKKQ-------NPGADGAAQVGGGAPQPGAAGGGGG---------GGSGGSPGPP 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	32/55 (58%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		33/210 (16%)
		Homeodomain	164..220	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		17/56 (30%)