Protein Alignment bsh and PDX1

DIOPT Version :10

• Sequence 1: NP_477350.2
• Gene: bsh / 35266
• FlyBaseID: FBgn0000529
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 74/272 - (27%)
• Similarity: 102/272 - (37%)
• Gaps: 78/272 - (28%)

  Fly   173 AAQHPPVPT------------TQPQPPPPPPLNGGSGASNGVLYPN-APY-----TD-------H 212
            |.|..|.|.            .||.||||.|..|..||......|: :||     .|       |
Human    19 AFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPYEVPPLADDPAVAHLH 83

  Fly   213 GFLQMTLGYLSPSSGTY-KSVDPYFL---------------SQASLFGGAPFFGAPGCVPELALG 261
            ..|...|....|.:|.: :..:|..|               ::|..:.|....||....||
Human    84 HHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPE---- 144

  Fly   262 LGMGVNALRHCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWFQNRR 326
                       ..::.||.::..||..|||.|...:|:|.|.|||||..|.|:|..:|.||||||
Human   145 -----------ENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRR 198

  Fly   327 MKHKKQLRRRDNANEPV------------------DFSRSEPGKQPGEATSSSGD--SKHGKLNP 371
            ||.||:..::......|                  :.....|...||.|...:..  ::.|:|.|
Human   199 MKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPPPGGAVPPAAPVAAREGRLPP 263

  Fly   372 GSVGGTPTQPTS 383
            | :..:| ||:|
Human   264 G-LSASP-QPSS 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bsh	NP_477350.2	Homeodomain	275..331	CDD:459649	28/55 (51%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		17/53 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		13/36 (36%)
		Antp-type hexapeptide	118..123		0/4 (0%)
		Homeodomain	147..203	CDD:459649	28/55 (51%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		15/75 (20%)